I suspect the unvarnished truth will be that the hgh + metformin+ DHEA + vit D / Zinc protocol does reverse thalmic involution but the price to pay is FASTER aging of most if not all tissues during the treatment time — that’s what Bryan Johnson reported of his personal results and that’s a side effect to reasonably expect from HGH. It’s a potent mTOR activator plus there are insulin implications.
I’d say that’s still a price worth paying for essentially resetting one’s immunity since the treatment is one and done after the original cycle and you wind up with a working thymus instead of a lobe of fat. Other interventions can then be used to hopefully reverse the damage on the other fronts. But yeah it would be nice to see all patient data.
Sure. Here’s the thread and pictures. More before and after pics of my lips through another intervention if you keep scrolling (spoiler alert, zero fillers ). I’ve seen real people in skincare FB groups get real results from procedures which is what got me interested in trying. Other than surgery though, which I have no interest in, none of them do miracles in a single session or two. Consistency is key and for me both for budgetary and logistical reasons that means DIY. That takes discipline. It’s easy to press the trigger on a device then let it collect dust on the shelf. Yes certain stuff works but must be used diligently.
Scroll to the top. Somehow can’t link it from the top.
No, it is not just his skin and hair, his gait and his posture look better/younger now than I see him in some 5-7 years old videos. Plus, as I said, Noone in the longevity field (i.e. Attia, Sinclair and many others) and do mean no one looks younger than couple years their real age. When I first ran into him in one of his recent vid’s I said to myself he’s probably around 60 but looks good even for that age. When googled and found out he’s 73 I was really surprised. again, if someone preaches something they better look the part. don’t be like the Atkins diet doctor that said his diet is great for heart and then drops dead at 70 of a heart attack LOL.
He looks remarkably good for his age and naturally it makes me pay closer attention to what he’s got to say. Incidentally he’s how I heard of rapamycin. His study on thalmus rejuvenation made some noise or otherwise ended up on my feed and naturally what I did was look up dissenting views / skeptical takes. The first one that popped up was Peter Attia’s claiming the study was very poorly designed, that the clocks don’t even properly measure anything, and that the dosage had been tweaked for every patient making results so hard to replicate, that there was self selection bias from the participants being health nuts, and that metformin alone can probably account for at least some of the rejuvenation. Ended by saying something to the effect of, if we were to go by such thin evidence we should all be on rapamycin as it seems the #1 most promising anti-aging molecule. Looked THAT up, found Blagoskonny, and the rest is history.
Greg is enrolled himself in the TRIIM X trial. He was not enrolled in the TRIIM trial. He said he took HGH himself in 1995 but I do not know for how long.
Would it be fair to hypothesize that HGH is only pro aging if you can’t control the negative insulin sensitivity effects? I tend to think that as long as you can control glucose from worsening, it should be a net positive.
No clue. From my layman reading there were plenty of other mechanisms in it that could independently be pro-aging. Bryan Johnson takes a boatload of supplements to control his blood sugar: metformin and Acarbose and a couple more if I recall, so if he can’t control those downstream effects, who can?
My CGM readings in 2023 were materially better than 2022. I have posted the images. I dont take acarbose or metformin. I do take rapamycin and berberine, but i think the change is mainly a result of improved DNA transcription
A bit more pumps/fullness in my muscles, slightly improved endurance/cardio, and seem to be able to eat a little more without gaining fat.
I should disclose that Im already a fitness junkie and in really good shape. Also I am 38 and I am on TRT (140mg testosterone per week)
I probably would notice more dramatic benefits if I were older or overweight and sedentary, but I still can tell a difference in how I look compared to before.
Luke, all the research I’ve read (and there is a lot of it) is that higher Growth Hormone/IGF-1 levels translate into shorter lives. In fact a lot of effort and money (tens of millions of $ just into Loyal), is going into new drugs to lower IGF-1/GH as longevity drugs. Here are some threads and links on this: IGF-1 inhibitors and lifespan extension?
GH supplementation was big in the world of “anti-aging medicine” and the A4M about 15 to 20 years ago… when people are much older and in worse shape than you (say in their 60s and 70s) it is reputed that GH can make people feel better, stronger, etc.
But as more and more research came out around IGF-1 over the decades, it fell out of favor and became known as clearly pro-aging in the long term.
But there are likely short term benefits - especially after injury, etc.
Unless you’ve seen some research I’ve missed, I suspect the ideal dosing is going to be something that is pulsatile… periodically done when you need some benefits from the increase.
More info on Loyal for Dogs and their first drug which is an IGF-1 Inhibitor:
In large- and giant-breed dogs, breeding for size caused these dogs to have highly elevated levels of IGF-1, a hormone that drives cell growth. High IGF-1 effectively drives these dogs to grow large when they’re young, but high IGF-1 levels in adult dogs are believed to accelerate their aging and reduce their healthy lifespan.
LOY-001 extends lifespan in part by reducing IGF-1 to levels seen in smaller-breed dogs. The IGF-1 axis is one of the most well-studied longevity pathways. In model organisms from C. elegans to mice, reducing IGF-1 extends healthy lifespan, and increasing IGF-1 shortens healthy lifespan. In humans, certain centenarians have been shown to have genetically lower levels of IGF-1.
The breakthrough moment for Loyal was connecting the biological mechanism of big dogs’ size to their short lifespan, and recognizing the big-dog-short-lifespan phenotype may not be inherent, but instead a type of “accelerated aging disorder”.
We designed LOY–001 as a long-acting injectable administered by your veterinarian every three to six months. In parallel, through our recently-announced partnership with Crinetics, we’re also developing LOY-003, a daily pill to address this same IGF-1 over-expression.
@LVareilles no need to provide any buying info for HGH. Thanks @RapAdmin for the info. Yeah, since I don’t care much to gain muscle and the fact that it is not going to help with longevity, I’ll just pass on it.
I wonder if there is a benefit of cycling HGH and Rapamycin, but I fear that there is not much to find in the literature. So we will have to guess again:
Do large grown animals live longer on Rapa? Yes!
Do large grown animals on Rapa live as long as small grown animals not on Rapa? Idk.
Do small grown animals live longer on Rapa? Yes!
Do large grown animals and small grown animals both on Rapa share an equal lifespan? So do large animals profit more? Idk.
Does the lifespan of a small animal on HGH equal the lifespan of a large animal?
Does Rapamycin cause the thymus to shrink? I think, I’ve read something like that. Have to check again.
I think this is a good debate but just like with most things, I think there is a middle ground
GH/IGF-1 deficiency contributes to physiological age-related cardiovascular modifications, such as decrease in the number of cardiomyocytes [41-43], rarefaction of coronary arterioles [44], increase in fibrosis and collagen deposition [45-48], reduced protein synthesis [49] and alteration of contractile proteins with reduction in myosin-actin bridges [50].
). I’ve seen real people in skincare FB groups get real results from procedures which is what got me interested in trying. Other than surgery though, which I have no interest in, none of them do miracles in a single session or two. Consistency is key and for me both for budgetary and logistical reasons that means DIY. That takes discipline. It’s easy to press the trigger on a device then let it collect dust on the shelf. Yes certain stuff works but must be used diligently.