Did any folks start out feeling somewhat fatigued by their weekly dose of rapamycin, but after several weeks or months they did not notice any fatigue or ill effects at the same dose? That to me might indicate improvement of cellular health or mitochondrial health.
Taking rapa to hopefully improve cellular health, reduce inflammation, improve mitochondrial health, reduce senescent cell burden, as I had a debilitating bout with levofloxacin 4 years ago, but was severely fatigued and exercise intolerant for about 2 years.
Yes, I often feel fatigued for the rest of the day. I’ve gotten used to it so it doesn’t affect my ability to function. Just a mild side effect. I have stretched out the dosing to 10-14 days vs. 7. I use 5 mg.
I concur with the others… I dose at night after a good workout… sleep through it. I awaken feeling a bit off and slow for the next day --which I do not workout the day after my dose.
After that initial post dose day… back to normal 100%.
I noticed that i feel fatigued around 4-4,5 hours afterwards, and that whatever time that is, I can fall asleep if I want to. The day after lately this is gone.
It might not be a direct result of the rapamycin, but rapa may be in the causal chain.
For example, I’m convinced, after a good number of repetitions, that rapa can enable EBV (Epstein-Barr Virus) to reactivate, which absolutely can cause fatigue. (Almost everyone has EBV–95% of population–but for most, it’s latent and doesn’t reactivate. Though I suspect some people don’t realize what’s going on when it does.) It can feel like a minor flu, or fatigue. Typically, your body fights it back to a latent state.
I’ve put off posting about Rapa & EBV until I had something useful to say about either possible causality chains or methods to address it. This may not be what’s happening for you, but I thought it might be useful to surface it in brief, so it’s in your mind as a possibility.
Yes, the first few times. I took the rapamycin in the morning as I had read here that most people felt awake and energized and I proceeded with my workout but felt so weak from just 2mg. But now I have taken upto 16mg with grapefruit juice and notice nothing anymore
Yes, research indicates rapa can suppress EBV lytic replication (that’s the active phase of the virus). By inhibiting lytic replication, rapa may reduce viral load and help limit the spread of viruses like EBV.
At the same time, rapa can suppress (at least some) immune system functions and thereby reduce the body’s ability to control viral infections, allowing latent viruses to reactivate.
I suspect that it varies across people, rapa protocols, and immune systems.
I skipped my 5mg weekly dose yesterday to see if I have more energy this week. I still find it odd that the fatigue is a delayed response that doesn’t happen until a couple days after I take it so I’m not totally convinced it’s the Rapamycin causing it. But we will see how it goes.
@Agetron I think I’m going to try taking Rapa before bed as well. Since I get tired from Rapa, it shouldn’t bother my sleep. In fact after about 6 hours I feel wiped out. It might even help my sleep if I take it in the late afternoon, and then I won’t have to deal with feeling tired the day of.
I am with @ Joseph_Lavelle on this. I get a nice afternoon nap on my dose day. Tried it at night and felt it synced nicely with a sleep fasted state. Only tried it once as I am now on a rapamycin vacation but will consider taking it at night consistently.