Is anyone here micro dosing GLP-1?
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Not sure what dose people consider micro but currently doing 3mg tirzepatide weekly. Mainly due to semaglutide study that showed some cartilage regen when mixed with intra-articular HA. Had A2M, PRP, HA injection in my right knee combined with 3 months of tirzepatide. Will see what MRI looks like after 3 months of therapy and rehab.
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I am macrodosing it.
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I’m interested in this as well. I expect to have some tablets of Sembolic 7mg (by Torrent Pharma), a generic oral semaglutide tablet, soon and was wondering what might be a reasonable dosing strategy.
My goal is primarily to lose all visceral fat, as measured by DEXA. Perhaps a total weight loss of 5 to 10lbs.
Should I dose once every few days? Once a day initially, then after meeting my goals less frequently? I’ve not seen any data on this type of thing. But I know people have been trying things on the injection side of things.
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I just ordered a vial from a reliable publicly traded Pharma, from my India source. I will be injecting .01mg a fraction of the weight loss dose. Total cost by way of Wisdom $93.00
What is you dose? Tablet of injection? Did you get if with a prescription or from a foreign source?
I’d like more information because daily dosing of a drug with a several day half life doesn’t seem to make much sense.
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Some VAT is necessary to protect your. organs.
VAT = visceral adipose tissue
I’ve got to get one of those scans done 
Have a Renpho Morpho 8 lead scale, it is also dual frequency, been using it for 4 or 5 months now. It’s not comparable to DEXA for sure but it can indicate a trend.
Mine indicates a steady number of 3 since I started using it, which is way down the scale.
To reduce my VAT I do 2 things
- GLP1 (Retatrutide) - clinically proven method, dosing once per week with my maintenance dose for the past 2 years, after 1 year losing 55lb = 3 years total
- hGH secretagogues to increase my nightly hGH output, hGH is clinically proven to reduce VAT
Here is a bit of info on a way to use a BIA type scale to correlate with your DEXA scan. Also the waist to height ratio appears to be a reasonable way to understand VAT.
renpho morpho vs dexa for visceral fat measurement (1).pdf (869.0 KB)
And a spreadsheet
bia_dexa_calibration_template.xlsx (26.0 KB)
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comparative info on
semaglutide vs tirzepatide vs retatrutide
compare GLP1’s semaglutide vs tirzepatide vs re.pdf (537.5 KB)
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@Steve_Combi
I posted this somewhere the other day, but I did a test with 3 scales after my dexa and one was renpho… all three drastically overestimated visceral fat… (but yes, they are supposed to be great for tracking trends)
I have .75 lbs according to dexa, and the scales were in the ballpark of 3ish lbs.
I’ve been curious… does Retatrutide reduce visceral fat independent of weight loss? I maintain my weight on my dose, so I have wondered if it’s chipping away at my visceral?
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So far I have not been able to find any evidence to support daily dosing of the long acting glp1’s. Help from AI has been difficult because it doesn’t understand why anyone would do that lol.
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I take 2mg Retatrutide per week and split 1mg Monday morning and Thursday evening. I don’t know if you would call that a microdose, but I am splitting the dose up. I was taking 3mg at once point on MWF but now back to 2mg.
As far as I am aware, all the studies have used once weekly dosing so we were just kind of speculating here. A lot of people microdose testosterone injections too.
I don’t feel like I use a high enough dose of Retatrutide now to need to take more frequent injections than that.
I wouldn’t put microdosing testosterone and GLP1 in the same category. Testosterone requires more stable levels over time to avoid side effects. Plus, it’s a hormone that affects mood, energy, and blood chemistry, among other things. Semaglutide is a GLP-1 peptide. It doesn’t convert into other hormones, the body is generally more “tolerant” of the steady-state level it reaches, however it reaches it.
didn’t @adssx shared many papers in canagliflozin thread that sglt2 inhibitors have been shown more beneficial or am I misremembering, glp123 drugs are awesome btw
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Hi
I do 0.5mg of retatrutide every monday to support insulin sensitivity while using exogenous growth hormone. I don’t feel anything.
At 1mg a day I start to be full quickly and 2mg I lose weight and can’t finish my plate.
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Does reta start to degrade like other peptides once it has been reconstituted?
Yes, of course. The question you want to ask is what does degradation look like over 30, 45, 60, 90 days.
Data is more mixed compared to tirzepatide, but generally 30 days is fine. I’ve seen mixed results for 45 to 90 days, with some batches with minimal mass loss and maintaining purity and other batches with a drop in purity (e.g. 99 to 97%).
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Not really. Someone posted on X that they tested a pre-mixed Tirzepatide vial six months later and it was still more than 99% potency.
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I don’t think there are many papers comparing SGLT2i and GLP-1RAs head-to-head and finding that GLP-1RAs are significantly better than SGLT2i. Most papers find that both are beneficial (and the benefits might be additive). It might also depend on the condition. For obesity, GLP-1RAs are obviously better for instance.