GERD, PPI use and longevity

For anyone who deals with GI issues, I would strongly recommend tributyrin. This is one of the few supplements that I strongly believe in.

I think it was one of the primary catalysts in allowing me to heal from a debilitating bout of gastritis that lasted for 3 years.
I’ve taken it daily for 2 years now and will continue to take it.

Sounds like we have very similar issues, and I agree that QoL is very important. Do you split the Fatomidine into two daily doses? 10mg morning and 10mg evening? Or all 20mg in the morning?

Great info.

Do you know if they can perform the ARMA procedure on someone who already had TIF?

EDIT: It looks like the procedure is only available in a few countries and I’m not sure the USA is one of them.

I’ve had good results with the peptide BPC-57, both injections and capsules. A moderate dose of 250 mcg EOD is effective. Unfortunately, the benefits cease when the use is discontinued.

I was able to get it for a relative of mine through Sigma Medex on Indiamart back in August while he waits for surgery. I don’t remember how much it was, but it wasn’t expensive. Brand name was Vonefi.

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Good looking out. I just found it on Indiamart

I don’t think I’ll order any at the moment (want to give Famotidine a shot first) but just in case, they don’t ask for a prescription, right?

A new finding with limited research, PPI’s may also significantly interfere with the biosynthesis of acetylcholine.

https://alz-journals.onlinelibrary.wiley.com/doi/10.1002/alz.13477#:~:text=A%20recent%20study%20showed%20that,neuronal%20signaling%20in%20the%20brain.

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No, you don’t need a prescription on IndiaMart. But you should be aware of any drug import laws in your home country and be sure not to order anything controlled. You need to check for drug interactions if you take anything else. Ideally of course, your doctor should give the okay for any medication, and then IndiaMart becomes an affordable source of medication when your insurance isn’t adequate for reducing cost locally.

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I take a lot of sodium alginate that I make into a gel after eating, before bed, before gym. I’ve gotten foam wedges for the bed, but don’t like them. I’d like to get the LINX procedure performed next year, unfortunately the insurance calls it exploratory and currently doesn’t cover it. I’ve been taking PPI’s for years, but take magnesium malate and vitamin D and B to compensate.

How has TIF worked out for you?

Anyone here dealt with functional GERD? All the same symptoms, but it’s not an acid issue, pH is normal in the esophagus; instead it’s esophageal hypersensitivity.

I tried PPIs with limited success. Started sertraline 25mg a couple days ago and my GERD symptoms have been reduced dramatically. Thing is, I really don’t want to take SSRIs over the long term.

Any thoughts on alternative treatments for functional GERD with better long term safety profile than sertraline?

I have successfully treated the two-headed monster of acidosis and acid reflux, conditions that feed on each other and are aggravated by CKD. Here’s my protocol.

800 mg of magnesium citrate, 2x/day
600 mg of calcium citrate, 2x/day
1/2 tsp of sodium citrate, 2x/day
A Mediterranean diet that’s at least 70% alkaline
Additionally, an apple a day, or at the first sign of turbulence. You’d be surprised how effective an apple can be as an antacid tablet.

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Try Psyllium husk for GERD, worked very well for me. 3 tablespoons before lunch mixed in some juice. Fixed digestion system in every way for me, not only GERD. Very cheap, worth a try

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Good call, seems to be some evidence for this:

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Thanks Tim! When do you take these? Empty stomach before meals?

Seems very similar to @John_Hemming’s citrate protocol. Is that where you got it from?

I couldn’t find any evidence of these helping with GERD besides sodium citrate neutralizing stomach acid. There is also evidence that calcium helps tone the LES, and calcium citrate is one of the most absorbable forms of calcium.

@EverVital

With meals. And yes, I adopted John Hemming’s protocol. And I am careful, as he advises, taking a fraction of what he consumes. Monitor your blood tests.

Both magnesium and calcium on their own are common ingredients in antacids, and citrate on its own is converted into bicarbonate. Then why not take bicarbonate directly? Because one molecule of citrate can produce three molecules of bicarbonate without the volcanic effects of sodium bicarbonate.

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Potassium citrate has its merits

Yes, in moderate amounts. The K adds up quickly for us semi-vegetarians.

Something I stumbled across a few years ago has enabled me to stop taking PPIs. These little tablets seem to settle everything - sure do eliminate gas, bloating, pain, and GERD. They are called “Tummy Soothers” and are produced by a company called “St. Claire’s”. Their effects certainly have been saintly for me!!! Ingredients: organic molasses granules, organic slippery elm bark powder, organic essential oil of fennel, anise, peppermint, spearmint, ginger, coriander, cardamom, and eucalyptus. I would much rather take these than PPIs. After contracting C-Difficile during a hospital stay, I was dealing with frequent tummy problems. No more…

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Eucalyptus oil is toxic when taken orally. The small amount you take is probably safe, but it may be cumulative.

The essential oils are really interesting, but as with any molecule people need to be careful.