Yes, slowing it down is the main thing we can do today. I have been trying to slow down AGE formation for 15 years.
Regarding Pankaj, I am no fan of his GLYLO product for reasons I have explained elsewhere before. I don’t think the GLYLO product is novel at all and I think the marketing of it is downright misleading. Here are the reasons why I think so.
The GLYLO product contains five ingredients; Alpha-lipoic acid, nicotinamide, pyridoxine, thiamine and piperine. Only two of these, namely pyridoxine and thiamine, have some direct antiglycating effects. The others do not. Those two ingredients are not particularly powerful and the doses of them in GLYLO are not particularly high, certainly not more than a whole lot of people have already been getting for many years simply by taking multivitamins or vitamin B complex supplements.
GLYLO is claimed to result in weight loss and increase insulin sensitivity. That’s not at all unreasonable. Alpha-lipoic acid has been found to improve insulin sensitivity so it’s not unreasonable to claim that GLYLO can improve insulin sensitivity. Alpha-lipoic acid has also been found to help a little bit with weight loss, at least in overweight/obese adults. It’s possible that this is a result of less cravings so the claims of GLYLO helping with cravings are not entirely unfounded. However, to the degree that that’s true, that’s not novel nor can alpha-lipoic acid be particularly effective at inducing weight loss. It’s been on the market for well over a decade and taken by thousands of people and weight loss is not a common experience from taking it.
Regarding the Alpha-lipoic acid in GLYLO, nothing is stated on the label regarding whether this is racemic alpha-lipoic acid or R-alpha-lipoic acid. When this is not mentioned it almost always means it contains racemic alpha-lipoic-acid, which is less expensive and is inferior when it comes to health. The racemic alpha-lipoic acid is known to be less bioavailable than the natural R-alpha-lipoic acid and to have higher chances of causing potential harmful effects. This was already apparent more than a decade ago. The fact that GLYLO contains the cheaper racemic alpha-lipoic acid means that they either are unaware of the superiority of the R-form or are simply cutting corners in the product to make production cheaper. Either case is a red flag IMO.
Regarding the Vitamin B6 in GLYLO, I recall an article on the longevity.technology website about GLYLO, supposedly written after interviewing Pankaj. That article stated that GLYLO contains pyridoxamine. However that is incorrect. GLYLO does not contain pyridoxamine, instead it contains pyridoxine, which is a cheaper form of vitamin B6 that is not as effective as pyridoxamine at inhibiting glycation. Pyridoxine and pyridoxamine are two vitamers of B6 vitamin with different properties when it comes to glycation. Pyridoxine is the most common form found in all kinds of multivitamins and vitamin B formulas but it’s the least effective against glycation of the vitamin B6 vitamers. Pyridoxamine on the other hand is not found in such formulas and is hard to find and more expensive. However, it is pyridoxamine that is a stronger antiglycating agent than pyridoxine!
I know that probably the main reason they put pyridoxine in GLYLO rather than pyridoxamine is that the latter was categorized as a drug some 15 years ago ago because some drug company realized it’s benefits and wanted to patent it. So it’s understandable if they can’t put pyridoxamine in GLYLO and I can sympathize with that. But they should at least be honest about that and not claim that it contains pyridoxamine in interviews when it doesn’t. Note that this is important since the mouse studies they used as basis for the benefits of GLYLO used pyridoamine not pyridoxine! But fortunately for them, most people don’t know the two forms have different effects.
Pankaj claimed that his lab has discovered the combination of supplements in GLYLO but I think that is also misleading. The insulin sensitizing effect of alpha-lipoic acid has been known for almost two decades now and the slight antiglycating effects of thiamine and the B6 vitamers (particularly pyridoxamine) has been known for over 15 years and many people that I personally know that have been around the longevity industry for long have known this and taken all these ingredients for these purposes for many years. The antiglycative effect of this product will be very small at best for most people except perhaps in some individuals that happen to respond unusually favorably to the glucose lowering effect of alpha-lipoic acid, in which case the antiglycative effect is merely secondary to lowering of average glucose levels.
The truth is, inhibiting glycation in humans in vivo is very hard to do. There are some ingredients that can have very small effects but none that are available and can inhibit glycation strongly in humans in vivo. The most effective way to inhibit glycation is still simply to keep the average blood glucose as low as possible.
Also I’m pretty sure some, if not most, of the benefits of GLYLO seen in the animal studies are explained largely by inadvertent calorie restriction (the group of mice given GLYLO ate less than the controls), but calorie restriction has major health benefits and also generally reduces whole body glycation.
Having said all this, I still very much appreciate the work Pankaj and his team are doing. I commend them for trying to work on an overlooked area of aging. I just don’t like the misleading hype and marketing surrounding the GLYLO formula.