There’s absolutely a placebo effect. Between February and October 2023 with a handful of weeks off in the summer, I’d been taking what I thought was 5mg of sirolimus with grapefruit juice, and felt an extra pep and improved energy. Turned out I was taking a fraction of that because my vehicle was siroboon from India, which barely made a blip in folks’ blood level of Sirolimus who actually got their blood drawn…. Granted because 5 mg + GFJ would have translated to a large dose if this had been the real deal, then even with siroboon I might have obtained a non negligible amount of sirolimus, but still, the placebo effect was strong. I even got a mouth sore in sympathy with other folks .
In another thread here I noticed a few people who found out they had been in the control group of the rapa trial could hardly believe it as they thought they’d experienced all the classic symptoms ….
M-tor inhibition effects would not occur in 20 minutes, the rapamycin barely makes it to the liver in any significant amount for its first pass metabolism within 20 minutes…
I have been on Rapamycin for 3.5 years…
I started out at 6mg siriolimus right from the start – weekly before bed. I noticed several hours after dosing a tinnitus like ringing in my ears. This continues to occur at every dose…every time By morning the ringing is dull or is gone.
Also,in my first weeks… I felt a heaviness… fullness in my heart. We know that it repairs the left ventricle of older dogs. Woof!
That heart fullness stopped after my first month of dosing as I recall. I have no plaque or calcium according to my coronary calcium scan 2 years ago.
Right? I’ve done 2 serum level tests ~3 hours after ingestion of 6mg zydus-brand sirolimus /w a 10ml shot of olive oil. First test was 11.01ng/ml, the second test was 10.76ng/ml. Is that good? Dunno and no one can say for sure. I’m shooting for ‘detectable’, and by day 7, ‘not detectable’.
So far I’ve not experienced a side effect that was noteworthy.
Any effects you perceived from your first dose could be a number of things… it could be a reaction from some food or supplement or medication interaction with the rapamycin you just took (if you have 't already, please read this thread on food / supplement interactions with rapamycin: Rapamycin Interactions with Other Food, Drinks, Supplements and Drugs ).
Are you taking any other medications?
Track what you eat / take prior to dosing rapamycin so you can start to identify any patterns.
Or perhaps its a unique or rare biological reaction that you get. Some people here have reported negative reactions on as low as 1mg of rapamycin (though that is rare). Most people report not obvious side effects, and no obvious immediate benefits. See:
Or, the feelings you experienced could be just something else.
I would just track your pre-dosing routine and diet / supplements / medications - note them down in a journal, and then note any feelings over the hours and days afterwards, to try and see if there is a correlation.
.
