The reason for trehalose.
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I toke 100g Trehalose and 25 Acarbose today, and had bad diarrhea.
My strategy is to take Trehalose with Saccharomyces boulardii next time, Saccharomyces boulardii releases trehalase which helps hydrolyzing Trehalose, but I don’t know if adding Saccharomyces boulardii eliminates the benefit of Trehalose?
The rationale is as shown below. Trehalose can’t be directly absorbed, almost all Trehalose are hydrolyzed to two D-glucose, only less than 0.5% of Trehalose can be absorbed by passive diffusion.
I guess the autophagy effect is not induced by D-glucose, it’s more likely the 0.5% of Trehalose absorbed did the work. Here is the dilemma, people who lacks enzyme trehalase has diarrhea, but people who has abundant enzyme trehalase converts almost all Trehalose to D-glucose, then there is no Trehalose absorbed.
Should I add Saccharomyces boulardii to prevent diarrhea? But Saccharomyces boulardii hydrolyze Trehalose to D-glucose, it’s equivalently drinking the glucose sugar water, does it also activates Autophagy?Any thoughts?
Do you have other strategy to increase the absorption of Trehalose while avoiding the diarrhea?
When ingested, trehalose is not assimilated as a disaccharide
into the blood stream. Rather, it is enzymatically
hydrolyzed in the small intestine by a trehalose-specific
disaccharidase into two D-glucose molecules, which are
subsequently absorbed and metabolized.
In people who can not absorb trehalose normally due to a lack of trehalase it is thought that all absorption that occurs would be via passive diffusion; in regards to disaccharides in general, the amount absorbed by passive diffusion during instances of malabsorption tends to be around 0.5%.
I am a great believer in the Examine reviews of supplements. I took trehalose for a while and dropped it because I just don’t need another fart diarrhea-producing supplement in my daily stack. Acarbose may be worth taking, but it has caused me to drop carbs to a minimum to prevent the unpleasant side effects of acarbose.
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I have never seen any good evidence of trehalose being bioavailable in humans. The diarrhea many people experience from taking it supports this, as it is a clear sign of it not being absorbed.
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I don’t either but I just bought another kilogram because it actually makes my espresso taste great, autophagy is just an added benefit. I can handle 2 tablespoons/day without diarrhoea
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Yes in the worst case scenario the trehalose is acting like slower release glucose because it is broken down to glucose which is then absorbed.
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I just got some 3% trehalose eye drops for dry eyes made in France. Probably an insignificant amount, (though 0.5% from intestines might indicate that it only takes a small amount of it to have an effect) but I wonder if any might be absorbed by that alternate route. Or if it improves autophagy of drusen in the retina…
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FWIW:
Stevia is my artificial sweetener of choice. However, stevia extract is so sweet that it has to have an additive to bulk it up and make it reasonably close to sugar for teaspoon-to-teaspoon equivalency. Unfortunately, many brands contain what I deem questionable fillers.
For instance, one brand advertising itself as “Stevia in the Raw” actually contains cane sugar.
How they manage to get zero calories from this is a mystery.
A few brands contain erythritol which is sweet, but much less sweet than stevia extract.
It’s nice that the cheapest brand from Walmart actually contains erythritol as the filler.
So it’s a good way to get some erythritol in our diet. It’s also nice that they list the fat, carbohydrate, and protein on their label. Fat and protein? Of course, the labeling from a giant like Walmart is also confusing. The same label lists 0 protein, then a little further down lists 4 grams of protein. Maybe the top is for the stevia extract and the bottom for the stevia extract + erythritol?
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Erythritol is sweet-less for me, I used aspartame, 0.5g aspartame is sweet enough for a 400ml cafe, but I need to put 20g or more erythritol to have the same sweetness, and 20g erythritol made me have mild diarrhea, that’s why I chose aspartame.
The erythritol is just a filler in the sweetener I use.
Why do you choose aspartame over stevia as a sweetener?
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If you like stevia but don’t want the fillers, try these stevia drops from Trader Joe’s. They have the best taste of any stevia, and it’s incredibly easy to get just the right amount. The link is for Amazon, for those unfortunates who don’t have a Trader Joe’s nearby:
I like the one I am using because I want the trehalose content and I have tried the drops before and they don’t work that well except for adding to drinks.
I take 1/2 tsp sublingually, occasionally. Skips the trehalase in the gut. Not as effective as intraperitoneal injection {used in the mouse study (https://doi.org/10.1080/15548627.2018.1434373)}, but much easier.
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Alzforum: Could Calming Overactive Ryanodine Receptor Restore Autophagy? | ALZFORUM.
https://www.alzforum.org/news/research-news/could-calming-overactive-ryanodine-receptor-restore-autophagy