Has anyone had to stop taking Rapamycin because of fatigue that didn’t go away even after a period of adjustment?
With each dose I’ve become progressively more tired. The first two doses (0.5mg one day apart) seemed to actually give me energy, although an underlying, low level fatigue was still present. I didn’t have any significant response to the 3rd dose (1mg two days from the previous dose), certainly no “rush” as with the first two. It did seem to make me a bit more tired, although not debilitatingly so. The next day I felt as if I had a virus, extreme joint aches and felt affected by histamines, but the day after these symptoms were mostly gone.
I took the 4th dose (0.5mg two days from the previous dose) this morning and in less than an hour had become extremely sleepy. So far this fatigue hasn’t lifted.
To be clear, I don’t suffer from CFS. I naturally have fairly high energy levels despite the Hashimoto’s, and I can make a direct correlation between these drugs (the Metformin and Rapamycin) and the fatigue.
I’m taking Rapamycin for Hashimoto’s disease on top of T4, T3 and LDN, as well as a number of supplements. My goal is to alleviate a series of debilitating inflammatory symptoms that thyroid hormone replacement and natural supplements aren’t improving. I had previously taken Metformin for this purpose, and while it worked, I had to come off it after 5 months because it gave me really bad fatigue. I spent these 5 months experimenting with different doses and intervals of dosage; in the end I was taking 250mg IR every 4th day but was still exhausted.
The Rapamycin does seem to be alleviating the inflammatory symptoms, but the fatigue concerns me as I’m afraid of a repeat of my Metformin adventure. Does anyone have any experience with this, or know what might be causing it? Would appreciate any help or ideas.
In case this is relevant, I’m taking Pfizer brand Rapamune.