I was considering taking these due to their longevity benefits (probably a conservative dose of 10mg each) and decided to look up some reviews of people who take them. Ezitemibe and empagliflozin have a 3.9 and 5.4 rating respectively on drugs.com and I was a bit hesitant after reading many of the lower rating reviews.
Can anyone here please share their experiences with taking either of these for longevity purposes (not prescribed for their primary purpose), and share your dose and give some context in lifestyle, stack and if you’re healthy / active? Did you experience any side effects or notice anything subjectively or objectively positive?
I’m not typically someone who gets nocebo effects and have used a number of longevity interventions, including rapamycin, acarbose, FOXO4-DRI, etc and so far have not had any significant issues, mostly positive experiences. I would like to broaden my stack however the reviews I read made me question if it was a good idea.
I’ve been taking empagliflozin for about 3 years. No side effects. Flattens the post prandial glucose spike. I take mostly 25mg/day morning. No complaints. It works as advertised.
Active and healthy. I exercise 4 or 5 days a week, alternating cardio and weights. No impact on any exercise dynamics.
I also take Ezetimibe - also great. No side effects. My LDL-C is about 45ng/DL. I also take a statin and bempadoic acid.
Some of the reviews sound pretty horrifying, though i guess the outliers are more likely to take the time to write something. I take lemborexant nightly and its beem a godsend for my insomnia withno issues, but the reviews are pretty awful for that too.
Most of the people taking this drug are probably very unhealthy, with many issues. We here are not the normal bunch, and I would suspect that healthy people are less likely to have issues. I haven’t heard of too many problems… I think one person mentioned UTI as an issue. If you haven’t already, I’d suggest you scan the (long) thread on Canagliflozin: Canagliflozin - Another Top Longevity Drug
I did read through that thank you. I was just surprised by the reviews on the site i mentioned. You’re probably right about it not being the same for healthier folks compared to people with multiple comorbidities.
Oh - and perhaps the biggest side effect I’ve noticed with the Empagliflozin is that my Uric acid levels is through the floor… off the top of my head I think it was about 3.3. It was flagged as too low, but it seems likely, from the research, that lower is actually better (or more optimal). See: Is lowering uric acid useful for longevity?