I was considering taking these due to their longevity benefits (probably a conservative dose of 10mg each) and decided to look up some reviews of people who take them. Ezitemibe and empagliflozin have a 3.9 and 5.4 rating respectively on drugs.com and I was a bit hesitant after reading many of the lower rating reviews.
Can anyone here please share their experiences with taking either of these for longevity purposes (not prescribed for their primary purpose), and share your dose and give some context in lifestyle, stack and if you’re healthy / active? Did you experience any side effects or notice anything subjectively or objectively positive?
I’m not typically someone who gets nocebo effects and have used a number of longevity interventions, including rapamycin, acarbose, FOXO4-DRI, etc and so far have not had any significant issues, mostly positive experiences. I would like to broaden my stack however the reviews I read made me question if it was a good idea.
I’ve been taking empagliflozin for about 3 years. No side effects. Flattens the post prandial glucose spike. I take mostly 25mg/day morning. No complaints. It works as advertised.
Active and healthy. I exercise 4 or 5 days a week, alternating cardio and weights. No impact on any exercise dynamics.
I also take Ezetimibe - also great. No side effects. My LDL-C is about 45ng/DL. I also take a statin and bempadoic acid.
Some of the reviews sound pretty horrifying, though i guess the outliers are more likely to take the time to write something. I take lemborexant nightly and its beem a godsend for my insomnia withno issues, but the reviews are pretty awful for that too.
Most of the people taking this drug are probably very unhealthy, with many issues. We here are not the normal bunch, and I would suspect that healthy people are less likely to have issues. I haven’t heard of too many problems… I think one person mentioned UTI as an issue. If you haven’t already, I’d suggest you scan the (long) thread on Canagliflozin: Canagliflozin - Another Top Longevity Drug
I did read through that thank you. I was just surprised by the reviews on the site i mentioned. You’re probably right about it not being the same for healthier folks compared to people with multiple comorbidities.
Oh - and perhaps the biggest side effect I’ve noticed with the Empagliflozin is that my Uric acid levels is through the floor… off the top of my head I think it was about 3.3. It was flagged as too low, but it seems likely, from the research, that lower is actually better (or more optimal). See: Is lowering uric acid useful for longevity?
I have been taking 180mg of Bempedoic acid, and 10 mg of ezetimibe for ~2 years. I can attribute no symptoms of any kind to either of them. I was concerned about the possibility of tendon rupture associated with ezetimibe but I lift heavy weights and, while careful, see no sign of that weakness.
I have been taking Empagliflozin (usually 10 or 12.5 mg per day but sometimes I split a 25 mg tab into thirds) for ~four months and will soon get my next comp blood panel so can gauge its effects. Subjectively, I think the Empagliflozin makes me a little more thirsty. I have been careful to drink enough water. Unconfirmed but it might have a sight effect on my exercise capacity. No other effects that I can notice and definitely nothing negative. I agree that many of the reports of side effects come from unhealthy people and those who are unusually sensitive to pharma.
Don’t you mean bempedoic acid? BA is associated with (somewhat rare) tendon rupture, ezetimibe by itself is generally not (some reports of ruptures combinened with statins).
Also, it was thought that EZ is not associated with myalgia, but more recently ezetimibe too has been shown to cause muscle pain (Tom Dayspring, the lipidologist, has experienced myalgia himself). But no tendon ruptures.
Both are known to be pretty side effect-free, especially Ezetimibe. I learned not to read drug reviews online because my experience never matches any of the negative ones.
I’ve been taking dapagliflozin (I assume pretty similar to empagliflozin), EZ and BA with zero side effects. No UTI’s. I don’t feel anything one way or another.
My A1c has always been great, but I have large post prandial glucose spikes. Dapagliflozin and Acarbose help.
I’m taking dapagliflozin for general longevity reasons, I’m taking EZ and BA to help lower my lipids more than repatha alone can do.
I’ve been taking them both for over 6 months now. I haven’t been able to come up with a side effect for either other than I believe Empa makes me pee more often upon first 2-4 hours of taking it, thus I take it in the morning to avoid having to go at night (during sleep). I do 12.5MG Empa, and 10mg EZI five days a week. I usually rest everything for two days a week.
I take 10 of ezetimibe and 12.5 of empaglifizone. I give them both a 10/10 for side effect profile.
I take Dayvigo also and also 10/10 as far as side effects. The reviews are insanely scary.
Drug reviews are a terrible method for evaluating medications. The average poster can’t discern placebo effect (none of us can) and you only hear the bad stuff. Especially for meds that don’t make you feel better.
Drugs.com is such a disservice to all. I am thinking about a placard in my waiting room that explains the disservice they are doing to the health of Americans.
This is a YouTube script by a physician who is personally at high genetic risk for Alzheimer’s disease (carrying two copies of the APOE4 allele). He reviews a study published in Aging Biology that unexpectedly identified ezetimibe as a potential neuroprotective agent — not through its cholesterol-lowering mechanism, but through an entirely separate pathway in the brain.
Non-Cholesterol Benefits of Ezetimibe Discussed
The Core Mechanism
A hypothesis-neutral screen of FDA-approved drugs sought compounds that could disrupt the 14-3-3/hexokinase protein interaction — an early step in the cascade leading to protein misfolding in Alzheimer’s and other neurodegenerative diseases. Six drugs emerged from the screen; ezetimibe was the only cholesterol-lowering drug among them.
Key Findings from the Study
Reduced amyloid accumulation — ezetimibe significantly decreased amyloid buildup in human cell lines
Reduced tau accumulation — it markedly reduced tau protein, responsible for neurofibrillary tangles in Alzheimer’s
Boosted autophagy by ~40% — enhancing the brain’s cellular “cleanup system,” analogous to the effects of fasting
Animal model confirmation — amyloid reduction was replicated in C. elegans worm models
Human epidemiological data — in a retrospective analysis comparing 4,361 ezetimibe users to 945,000 age-matched controls, Alzheimer’s disease incidence was 8-fold lower in the ezetimibe group, independent of coronary disease status
Why Ezetimibe Specifically
Compared to the other five compounds identified in the screen, ezetimibe was favored because it:
Crosses the blood-brain barrier
Has an excellent and well-established safety profile (not associated with insulin resistance, diabetes, liver injury, or muscle damage, unlike statins)
Important Caveats the Author Acknowledges
The script is intellectually honest about limitations. There is no randomized controlled trial in humans, and the data come from in vitro cell lines, animal models, and a retrospective database analysis — all subject to confounding. The author stops well short of claiming ezetimibe prevents Alzheimer’s, while arguing the effect sizes are too large to dismiss and the mechanistic story is biologically coherent.
Desoxyn has high ratings on Drugs.com. This must mean that it’s safer than ezetimibe.
Let’s not forget that this is methamphetamine hydrochloride.
Anyway now we know the power of the placebo and nocebo effect, at least for Ezetimibe. There’s barely any side effect difference from placebo in clinical trials.
SGTL2 inhibitors can increase risk of UTI and yeast infection of genitals due to increase sugar output in urine. Main solution there is to make sure the area is clean.
Ezetimibe I take personally (10mg/d, have taken for years) and have zero discernible side effects. It’s highly effective in the job it’s supposed to do, which is lowering my LDL-C.
Empagliflozin I don’t take, but my friend is a pharmacist and he says the most common complaint from patients is UTIs - most commonly in women with obesity.