Nice, thanks for sharing from the perspective of someone who takes it as its intended.
Thanks for this reminder about potential benefits of Ezetimibe! I added 10mg Ezetimibe in March '26 to my stack (Iām an ApoE4 with elevated amyloid plaque & p-tau 217). I check my blood markers every 6 months or so for my N=1 trials. Comparing various labs for tracking AD biomarkers but Precivity AD is my earliest and most consistently used labs. I will be taking my 4th Precivity AD biomarker test in July/August (first one was in 2022). I will see if Ezetimbe lowers my numbers. Fingers crossed!
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Any experiences to share about Empagliflozin versus Canagliflozin? Are there benefits of one over the other?
I think they are very similar and your choice will be what works best for you. I tried canagliflozin but for some reason felt a lot of fatigue on it, switched to empagliflozin and no issues, so Iāve stayed with empagliflozin.
Threads you should read:
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Thanks for the thoughtful response. Maybe Iāll switch and see if I notice any differences.
What are your thoughts on dapagliflozin and its longevity promoting properties compared to empagliflozin? I ran it through chat-gpt and they seem similar as far as i can tell.
Canagliflozin is the only āflozinā that has been tested in rigorous mammalian lifespan tests (the NIAās ITP program)ā¦ so that is the only compound (I believe, unless I missed a study) that we have good data on. See: Canagliflozin - Another Top Longevity Drug
So - when we look at the other āflozinā compounds we really donāt know. If canagliflozin works for you, Iād use it because itās the best characterizedā¦ itās the one we know most about. The others āshouldā work, but we canāt be sure. We can be sure (at least in rodents) that canaglifozin increases lifespan.
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Yes thank you, this is a safe medical answer that a Dr might share. I did review the studies on conaglifloznen. Just curious on your own personal opinions if youāre open to sharing them. I will of course do my own research and make my choices freely. 
I think @RapAdmin did share his opinion above which is to say that most likely all āflozinsā have the same effect as Cana, but CANA is the one measured/studied and it showed positive effects on lifespan. I doubt him (or anyone else for that matter) could offer any more than that in a rational way. Personally, Iām doing EMPA but do have a big supply of CANA also and intend to use it when my EMPA runs out. So, Iām agnostic as to which should I use. Initially ( I think) I started with EMPA because somewhere on these boards people were saying it may have less side effects. Other than that I would have gone with what was tested/studied, CANA.
Also, lactoferrin might help. According to lactoferrin.co, " Lactoferrin may assist in maintaining a healthy urinary environment. Lactoferrin is an immunity protein that suffocates infection causing bacteria in your bladder."
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Iāve used a CGM (continuous blood glucose monitor) and tracked my blood glucose levels on both canagliflozin and empagliflozin. In both cases they seem to do a great job at flattening the post prandial (after a meal) blood glucose level. So from that standpoint they seem very similar (in my experience).
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Thanks, I decided to give dapagliflozin a try. I seen some comments about people tolerating it a bit better and it was also cheaper from my source by almost 50% compared to empagliflozin. With a lot of these things weāre clearly taking a bit of a leap of faith hoping for benefits beyond their intended functions. I was just reading the thread about dasatinib and quercetin potentially having negative effects on the brainā¦ Will have to take a closer look at those studies because I have used synolytics periodically like this that stack and FOXO4-DRI.
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Personally, I have ordered Empaone Empagliflozin 10 mg tablets from India. This brand is dirt cheap (~$30 for 200 tablets) and has a good reputation for quality. Previously I ordered Jardiance from India, but was still not cheap.
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