I may not agree with all that Dudley Lamming says, and he tends to take a much more conservative view on rapamycin that Matt Kaeberlein and most of the people on this forum, (which I suspect may be at least partly related to the fact that Dudley is the scientific advisor at a company developing a new MTOR inhibitor (Aeovian) who’s product seems likely to be competitive to rapamycin). It also seems likely that he is getting paid - either in money or company stock / options - which means he has a conflict of interest, and financial incentive to overemphasize potential issues with rapamycin.
But he was in the David Sabatini lab prior to starting his own lab, so definitely one of the top researchers in this area, and definitely worth listening to.
I am confused. I thought leucine was an mTOR activator and has the opposite effect of rapamycin and is used to increase immunity. Please refer me to a study that says leucine is an mTOR inhibitor.
“EGCG, curcumin and resveratrol, inhibit mTOR signaling at considerably high levels (micromolar ranges) in vitro.” Updates of mTOR inhibitors
"L-leucine (Leu) earns the greatest reputation for its unique function of activating the mTOR signaling pathway"
". Our research showed that Leu could alleviate the inhibition of p-mTOR, p-p70 S6K and p-4E-BP1 and reduce the content of TGEV. The results above indicated that mTOR activation significantly increased the expression of p-STAT1 and attenuated the TGEV infection. Furthermore, we confirmed that Leu could regulate the expressions of STAT1 and ISGs by enhancing the activity of mTOR, which is coherent with the results caused by MHY1485. Overall, our findings clearly demonstrate that Leu may promote STAT1 and ISGs expressions through activating mTOR signaling, with the consequence of alleviation of TGEV infection in enterocytes.
L-Leucine Promotes STAT1 and ISGs Expression in TGEV-Infected IPEC-J2 Cells via mTOR Activation
Thanks, I admit I am not really qualified to fully understand these studies. I have a kilo of leucine going to waste because I stopped taking it while taking rapamycin. I used to add it to my protein drink immediately after working out.