DIY Rapamycin Toothpaste and Flossing Paste

[Beth]

I can’t personally speak to NO because it’s above my pay grade, but I think @Joseph_Lavelle uses fluoride (hello Dr Ellie!) and it has found his NO has not been affected.

Perhaps he will chime in.

[Cole]

Haha, to be honest, it’s a pretty minor point. Fluoride lowers the risk of cavities, so I’m sticking with fluoride toothpaste regardless of whether it affects nitric oxide production. Plus, I never rinse after brushing—my dentist has always told me to leave it. If anyone happens to know the optimal concentration of rapamycin for oral use, that would be great; otherwise, I’m a bit hesitant to dive in.

[Beth]

This does not address your questions, but if you haven’t seen it yet, check out this thread.

I have been doing the protocol for a few months now and I’m experiencing what others have found…. This + no flossing = no plaque… WITCHCRAFT!

Wise Athletes episode on Oral Health

Sorry for the poor sound quality. This one was a technical issue hell. But, now I finally have a mechanistic model of how my mouth tries to stay healthy and repair itself, and how I am interfering with that process to my own detriment. Thanks to Dr Ellie. Key learnings for me: the mouth will heal itself from the damage done by eating, drinking, and bacteria de-mineralizing the teeth, but we often interfere with this process keep the mouth closed and empty almost all of the time (this fits with the nasal breathing advice I’ve gotten); stop eating / drinking all day long (only drink with meals, ideally) help the mouth remineralize after eating by de-acidifying the mouth (foods, xylitol, mouth rinse) the night time is the most important time to have a healthy mouth: prepare the mouth for sleep, and keep the mouth closed during sleep (avoid dryness) avoid or be careful with acidic drinks (citrus, apple cider vinegar, carbonated drinks, coffee) xylitol is a key tool for de-acidifyi…

[Olafurpall]

@Olafurpall

So far you have not provided any studies or good reasoning for thinking fluoride is harmful for NO p

Thanks for the study. The problem is, a lot of expert take something that has a grain of truth in it and completely blow it out of proportion. Yes, the study you link to does show that fluoride can inhibit NO production, but this was seen after exposure of the cells to fluoride for 24 hours! If you use toothpaste and fluoride mouthwash you only expose your oral cavity to fluoride for a matter of minutes. Only tiny amounts of it would be likely to be absorbed into the blood circulation likely after swallowing if you swallow some portion of it.

Importantly, the concentrations of fluoride the cells were exposed to in the study you linked to are far higher than those found in the blood of humans using fluoride toothpaste or mouthwash. The fact that the mechanisms for inhibition of NO production exists is interesting, but it doesn’t mean it has meaningful effects at real world concentrations.

Now if this doctor actually mentions studies that show that people using fluoride toothpaste or mouthwash have lower NO levels, or that concentrations of fluoride as low as those typically found in the blood can inpair NO production, then we might have a reason to be concerned about it (if we actually found those studies). But until then, I think it’s reasonable to assume it’s unlikely that using fluoride toothpaste or mouthwash will significantly influence NO production in the body.