DIY Rapamycin Toothpaste and Flossing Paste

Just a quick note: make sure the toothpaste contains the ingredient “Novamin”. Sensodyne sells a bunch of different toothpastes, but only the one with that specific ingredient actually works for sensitivity.

And with regards to this whole thread: what is the proposed mechanism of action here? Gums recede with age, and how is inhibiting mTor in the mouth epithelium supposed to help with that? I don’t quite “get” it.

I think it’s a bandaid and only work while the ingredient is on the teeth, and unsolicited advice: stannous flouride toothpaste can be considered the best toothpaste in general according to different metrics and studies depending on your priorities:

It is like a bandaid, but the effect is quite long lasting, in my experience. I had horrible sensitive teeth, and a few days after using Novamin 2x per day, they were significantly less sensitive. After using it for several years now, I simply don’t have sensitive teeth any more and haven’t thought about it for a long time.

In terms of cavity prevention, tooth decay, tooth loss, I have absolutely no idea. But being able to have a cold drink without wincing in pain is a huge quality of life upgrade!