Metformin hydrochloride is freely soluble in water so it would be easy to add to my solution.
Couldn’t hurt to try it.
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Here you go!
First crush with pliers in a pastic bag the following pills.
4 pills of 2 mg rapamycin (triangle beige)
4 pills 500 mg metformin (large white)
4 pills 2.5 mg minoxidil (small white)
3 pills 5mg finestride (small blue)
Add oderless DMSO 99.9 one fluid ounce and mix… let set 1/2 hour mix some more.
Puncture capsule or cut off end - 5 capsules of resveratrol… squeezre into mixture… use pliers.
Puncture capsule or cut off end - 5 capsules of Green tea - EGCG squeezre into mixture… use pliers.
Mix thoroughly.
Add 3 fluid ounces of 5% Minoxidil Hair restorer (I use Walmart Equate)
Mix thoroughly put in a bottle use an eye dropper to apply after showering in the morning and before bed at night. A lot of effort - but it works. And, changes grey hair to brown with blonde and red tints. Very natural. Grey gone.
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There just happens to be a huge sale on the skin cream I used as the base for my rapamycin mixture. It’s not the 16,000 positive reviews. It has the best dispensing system. Instead of unscrewing the top to get the cream, you just push the top down and a little dab of cream comes out in the center.
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just use dmso rather than the more expensive transcutol, works well for me . u just may have to get used to putting up with a little mostly itching feeling but only for a few minutes.
Great to hear no adverse side effects, but how about the good effects? Notice anything positive? I can see your point about spritzing vs lotioning, on your scalp. The issue for facial use is getting it to “stick” rather than run off, and avoid spraying it in your eye. Thanks for sharing your routine, your posts are very helpful.
The spritzer bottles I use make a very fine spray and I rub the excess in just like I would with a lotion. I use it mainly along with Retin-A for my sun-damaged skin. My main objective is to keep the actinic keratoses away. It seems to be working well, and my skin is also quite good for my age. I don’t want to scare you but you can look at a couple of my photos:
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We’re going to make our own rapa skin cream. But just one single question first:
We’re prefereing a liposomal version but Rapa is a really small molecule and we have some concerns that it will pass into the blood stream. Does it? Any hints?
The alternative is DMSO. A <=5% solution should be safe and should not transport rapa into the blood stream (unlike 70% or more DMSO which will definitly function as a drug carrier into the blood stream). But we think a liposomal version could be more effective (and we have all components already at home)
Transcutol is not available in the EU, so it is no option.
We have some equipment and knowledge in mixing our own creams, toothpaste and so on.
“Transcutol is not available in the EU, so it is no option.”
You might try looking for it under some of its’ other names.
“Ethoxydiglycol also goes by the name diethylene glycol monoethyl ether and is marketed under the trademarked ingredient name Transcutol®. As a raw material, it appears as a clear liquid and is water soluble.”
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Pharmacists in germany are using DMSO instead for rapa skin cream because they cant get transcutol (regardless of the name/brand).
It is possible to use trancutol in cosmetics in the EU. Range is up to 7% since 2017. But I’ve never seen any pharamacist using it. I cant get it in small amounts and esp not for private usage.
I think the only way to get transcutol is starting a cosmetics company and just buy greater amounts of it. But that isnt woth it. DMSO is a nice alternative (with some positive side effects) if we decide not to use our liposomal basis liquid.
I think liposomes are a much more elegant solution (if it wont affect the rapa blood levels). Pharmacists dont use liposomes because of … dont know. Maybe because of they’re using techniques from the early bronce age. I just never saw it.
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Hi Agetron, I’m looking into trying your solution and noticed that the Equate Minoxidil bottles are 2 fl oz, yet you mention adding 3 fl oz to the DMSO mixture. Are you actually using 1.5 bottles (for 3 oz) or only 1 bottle (2 oz)?
Also, how critical do you think the finasteride is? I mainly ask because at the moment it’s the only component that I do not have have any and would need to order it from India. Do you think it would work without?
I tried the Rivertown Minoxidil/Cyclosporine/Tacrolimus for a few months and haven’t seen any meaningful results. It also makes me feel horrible after using it, including drowsiness/tiredness/eye blurriness, so your concoction seems like the next thing to try, especially with the good results it’s produced.
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Correct - I use one and half bottles - they come in packages of 3 – Equate Minoxidil 5% at WalMart seems the cheapest. That comes to 3 fluid ounces in all.
As to the finasteride, I think there is a lot going on that if you skip the finasteride - I think you are fine.
Make sure you get the orderless DMSO and only use to fill in about 20 - 25% for the overall solution. Which would be about 1 fluid ounce or a bit less.
Note - on the resveratrol and Green tea - EGCG, adding those will tint the grey out of your hair. Less resveratrol less rust colored tint.
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I will add that I am also orally taking Minoxidil 2 pills 2.5 mg… so 5 mg at bed time.
An Old Medicine Grows New Hair for Pennies a Day, Doctors Say
Dermatologists who specialize in hair loss say that the key ingredient in a topical treatment worked even better when taken orally at a low dose.Link: https://www.nytimes.com/2022/08/18/health/minoxidil-hair-loss-pills.html
More on Oral Monoxidil success.
Link: Efficacy and Safety of Oral Minoxidil 5 mg Once Daily in the Treatment of Male Patients with Androgenetic Alopecia: An Open-Label and Global Photographic Assessment - PMC
There are videos that say you take the Walmart Equate topical minoxidil - use the eye dropper as oral sublingual – a few drops (under the tongue) if you don’t want to get a prescription. I tried it for a few weeks with no issues. Then, I got a prescription.
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Do you get any side effects with oral minox?
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None at all… the ankle edema I had… appears to be from my high rapamycin doses… 36 - 38 ng/mL. Once my dose reduced after 7 months… the edema went away completely.
That said some people (a few in the study) get ankle edema for a few months… then it goes away.
Link: https://www.nytimes.com/2022/08/18/health/minoxidil-hair-loss-pills.html
A new NY Times article on the topic of hair:
(as a side note, minoxidil tablets are available from many of the companies on the list of reliable online pharmacies, for very little money - i.e. $1 for a strip of 10 tablets of 5mg, which would need to be broken up to deliver the much lower dose used in the study). The doctor is quoted as now giving patients “effective doses of one-fortieth of a pill and began routinely prescribing the drug. That first patient still takes it.”
But there is a cheap treatment, he and other dermatologists say, costing pennies a day, that restores hair in many patients. It is minoxidil, an old and well-known hair-loss treatment drug used in a very different way. Rather than being applied directly to the scalp, it is being prescribed in very low-dose pills.
Although a growing group of dermatologists is offering low-dose minoxidil pills, the treatment remains relatively unknown to most patients and many doctors. It has not been approved by the Food and Drug Administration for this purpose and so is prescribed off-label — a common practice in dermatology.
At a meeting in Miami in 2015, Dr. Sinclair reported that low doses of minoxidil prompted hair growth in 100 successive women.
He published those results in 2017, noting that rigorous studies were needed, in which some patients would be randomly assigned to take minoxidil and others a sugar pill. But that has not happened. He says he has now treated more than 10,000 patients.
Recently, a rising number of hair-loss dermatologists have been giving the low-dose pills to patients with male and female pattern hair loss, a normal occurrence with age.
An Old Medicine Grows New Hair for Pennies a Day, Doctors Say
Dermatologists who specialize in hair loss say that the key ingredient in a topical treatment worked even better when taken orally at a low dose.
The research papers that have been published on this is below:
Background
Minoxidil and spironolactone are oral antihypertensives known to stimulate hair growth.
Objective
To report on a case series of women with pattern hair loss (PHL) treated with once daily minoxidil 0.25 mg and spironolactone 25 mg.
Methods
Women newly diagnosed with a Sinclair stage 2–5 PHL were scored for hair shedding and hair density before and after 12 months of treatment with oral minoxidil 0.25 mg and spironolactone 25 mg.
Results
A total of 100 women were included in this observational pilot study. Mean age was 48.44 years (range 18–80). Mean hair loss severity at baseline was Sinclair 2.79 (range 2–5). Mean hair shedding score at baseline was 4.82. Mean duration of diagnosis was 6.5 years (range 0.5–30). Mean reduction in hair loss severity score was 0.85 at 6 months and 1.3 at 12 months. Mean reduction in hair shedding score was 2.3 at 6 months and 2.6 at 12 months. Mean change in blood pressure was −4.52 mmHg systolic and −6.48 mmHg diastolic. Side effects were seen in eight women but were generally mild. No patients developed hyperkalemia or any other blood test abnormality. Six of these women continued treatment, and two women who developed urticaria discontinued treatment.
Female pattern hair loss: a pilot study investigating combination therapy with low-dose oral minoxidil and spironolactone
https://onlinelibrary.wiley.com/doi/10.1111/ijd.13838
Conclusion
Oral minoxidil was found to be an effective and well-tolerated treatment alternative for healthy patients having difficulty with topical formulations.
Blood pressure - systolic a bit lower too about 10 points from 137 to 127… A good thing.
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Any thoughts on using Rapacan versus Zydus for skin cream?
The lab reports (posted in another thread) seem to show that Zydus is more pure, but I can get Rapacan for $0.65 / mg versus $1 for Zydus.
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I use Rapacan because they seem to grind up easier in my mortar.
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I don’t think it matters much - I would go for the cheaper one for topical applications. You’re just dissolving it and the differences seen in the lab results are pretty minimal compared to the price difference. Also - topical doesn’t absorb into the blood stream.
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I wasn’t concerned about absorbsion in the blood stream, but I was concerned about putting “crap” on my face 
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Hello All,
They scammed me out of almost $250 of bitcoin. I placed an order for 2 products in February 2023, no response to any correspondence and did not receive any product. BEWARE ALL, RAPAMYCIN.STORE AKA RAPAMYCIN BUYERS GROUP IS A SCAM!! DO NOT USE THEM!! I hope that this post saves others from being scammed.
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mruffaner13, Thanks for reporting this. I’m sure it was a bad experience for you, but you’ve done a great service by telling us. I will avoid this company.
I’m always wary of sending money to a company by way of a money transfer company, especially if it is a foreign company. And, with Bitcoin which I have used, it doesn’t matter where the company is located there doesn’t seem to be any recourse for recovering those funds. Once they go off to that cryptic Bitcoin address in the cloud the recipient is in full control to keep the money penalty free if they so choose.
I wonder … do we have a topic for avoiding scams such as “Avoid These Scams” where all problems related to money transfer purchase scams can be placed (in one location) so as to black-list the dishonest companies and help rapamycin.news members avoid them?
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