DIY Rapamycin skin cream

I still have not seen any meaningful reason to add a cream like Olay to the rapamycin plus Transcutol+water mixture. It just seems like a waste of some rapamycin to me.
Put on the Olay afterward if you think you need a cream. I am finding that the straight rapamycin+Transcutol+ water is working great and I am seeing a reversal of age spots on my hands.

Most of these cosmetic creams are not effective, but they have put a lot of effort into absorption. None of my rapamycin is wasted other than perhaps a tiny, tiny bit at the bottom of the jar.

I think the rationale is simple - many people already use a body/facial skin moisturizer on a daily basis, so rather than add complexity to people’s daily routine the researchers just added it to something people might use daily already. So - minimizing people’s need for behavior change (which is always a good thing if you want people to adopt something new).

Plus, many of these moisturizers have compounds that are good for the skin - e.g. CereVe with Cerimides, etc. , so the addition of rapamycin makes a good product, even better, and you don’t need to change your daily habits.

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I find it less problematic than not knowing how much of my rapamycin has been dissolved. For all, I know any carrier such as Transcutol is already saturated in the cream and doesn’t dissolve any rapamycin at all. For those dissolving the rapamycin in some Transcutol or DMSO before adding it to the cream, it is a different story. Spritzing on a little Transcutol, rapamycin, and water solution before putting on the lotion is hardly a chore.
But, once you add rapamycin to any one of the myriads of creams on the market you have no idea what amount will be available for absorption or how much will be absorbed.
Just my opinion of course but I will choose what I consider to be the more reliable solution. (No pun intended)

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How much rapamycin are you crushing up, and into what quantity of liquid/cream are you mixing it? The mixtures are given in % of rapamycin, so a 0.045% solution is not necessarily 45 mg of rapamycin in a given quantity of liquid. Knowing the amount of rapamycin and quantity of liquid will let me calculate the % for comparison.

I’ve used about three of the 50 ml OneSkin OS-01 on my face over the past 6 months probably. While I do like the results generally, I feel it’s way overpriced. They suggest using it twice a day, and with that amount I could easily see going through two 50 ml tubes of it per month. At $100-120 per month it adds up. I would be more apt to buy if it were about $80 for 150 ml. It’s unclear if their Body lotion has the same quantity of the peptide. If we can get similar results with rapamycin skin cream I’d be happy.

Have you been using the Face or Body cream, and have you compared the two?

Please go to the top of the thread. I believe all of your questions are answered in the topic.

So… what has all your experiences with rapamycin cream been like, now that you have used it for a while?

Do you get phases of dry skin, like with tretinoin? Apart from this, how else would you compare it with tretinoin?

I believe it is called ethoxyldiglycol: Ethoxydiglycol | Lotioncrafter

What I am not sure is if it is any less pure than that sold by Lab Alley. Lab Alley’s product claims to be USP food grade purity, and sells for almost 2x the price.

Does anyone have any input on the purity of Lab Alley’s vs Lotioncrafter’s?

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Is LC Labs a trustworthy site to buy rapamycin powder? Will powder work or do I need the tablets? Where did you guys get it?

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Hi @vas and welcome to the community.

It you can get the LC rapamycin for your skin cream, its fine. I have a friend who works in a lab who ordered it for me, but most people are not able to do this.

The powder is easy to work with, with none of the extra material you get in the tablets.

But if you can’t get the powder, just using the tablets, as identified in this DIY rapamycin slin cream post at the top of this thread works fine also.

I think I am going to add Astaxanthin to my rapamycin skin cream. Here is a study that purported to show benefits from oral and topical application on skin. The ITP study showed a 12% increase in median life span from Astaxanthin (males only).

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It seems to be a pretty strong red dye… I think it would stain your skin.

Why do we dose daily for the skin?, wouldn’t one time a week be more consistent with what we are saying about typical oral dosing schedules?

I am aware of the daily use study that shows skin improvement.

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