Has anyone had experience with Adderall and Phentermine to compare with Modafinil? I have taken Phentermine and Adderall (not at the same time) and both destroyed my sleep no matter how early l took it. I would like to try modafinil but not if l can’t sleep on it.
Have you considered coffee?
Neurocognitive and Neurological Effects of Coffee and Caffeine: A Narrative Review
" Regular coffee drinkers have lower rates of several neurodegenerative conditions, including Parkinson’s disease and Alzheimer’s disease [1,2], dementia [3], stroke [1], and multiple sclerosis [2,3]."
“While most studies exploring the effect of coffee on the brain, neurogenesis, neuroplasticity, and synaptic plasticity have been conducted in animal models, several important clinical trials in humans suggest the role of coffee in human brain activity, as summarized in Table 1.”
Joking aside, I get all the effects you enumerated including mood elevation, clearing brain fog, increased focus, energy and wakefulness with coffee. The limitation is relatively short duration and habituation which can lead to dose escalation, but I’ve been lucky enough that in almost 50 years of almost daily coffee drinking I have not developed a bad need to escalate the dose. My morning small high quality coffee mocha still has stellar effects, as does my afternoon 4 cup drip. No impact on sleep that I can tell even if I occasionally have a very late after dinner cup with friends. According to my genetic data I’m a fast coffee metabolizer.
I figure if coffee does what I need my incentive to try something like modafinil is lower. I realize that everyone reacts to coffee slightly differently, but that’s probably true of modafinil as well. YMMV.
[quote=“CronosTempi, post:51, topic:23705”]
Have you considered coffee?
Yeah, but after the first gallon it loses it’s effect and makes me sleepy. 
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Combining both has been great for me
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Modafinil trivia. Those with COMT Val158Met Genetic Polymorphism feel little or no effect from Modafinil.
I have it and it does nothing for me
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DesertShores, I have had a supply of armodafinil for a year or so now and every time I try it I don’t notice any type of improvement. I use WakLert 50 by Sun Pharma. I’ve tried 50 mg at times and 100 mg at times without noticing anything although the research I read implies that it is the better of the two isomers found combined in Modafinil. In fact, it may leave me a little down after a few hours. I’ve probably given it 5 to 10 one-day trials so far.
If I want results I always use Modafinil and sometimes it does not seem to work, either.
Based on my research, Sun Pharma is a fairly reliable company in the Indian pharma sector.
I have noticed from this thread that some people seem to be non-responders, while others are quite sensitive to modafinil. I don’t know how old you are, but it might be a better performer for older people using it off-label. Having tried it for some time now, I can’t imagine wanting to quit.
In addition to energy and motivation, modafinil gives me a mental boost, almost euphoric.
I think I first heard about its off-label use from Aubrey de Grey. He is a big fan of modafinil, as are several other YouTube talking heads, such as Joe Rogan.
I was hoping to get the same experience from armodafinil, only for a little longer period.
I hope other members of the forum who have tried armodafinil will share their experiences.
I have actually ordered any yet, because I have other interventions in the pipeline, including ordering some more rapamycin.
I’m just a few years younger than you and I agree that modafinil may be more beneficial for older people than the young, excluding those using it for prescribed reasons. I agree with what Modafinil & Your Brain | Cognitive Vitality | Alzheimer's Drug Discovery Foundation says, and I think doctors should consider it as being potentially beneficial for their older patients. It bumps my dopamine up enough to improve mood and motivation for a good 6 hours or so at a dose of 50 mg to 100 mg. I try to make 50 mg work, but if it doesn’t kick in within two hours I’ll likely add another 50 mg. It makes me feel like I’m in my 30s again for that time slot. I avoid a full dose because it means a very sleepless night and I take periodic breaks every week or two.
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I am taking 200 mg and that works for me twice a week. If you buy from Jagdish in India, you get 2 options, mood:and Alert, , I take the Modifinil mood, has anyone tried the Alert?
Try 200 mg, it’s amazing. In between Modifinil we drink LUCID. Coffee, it has mushrooms in it and it not only tastes great it improves energy and mood.
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I found I couldn’t sleep the first time I took 200 MG of Modafini however I experimented and found an over-the-counter sleep supplement that works great. It is called ZzzQuil
I only take one even though they come in little packages of two, I tried 2 the first time and found I slept too long, so now I take one and it works perfectly. You might want to try that if you’re not getting enough sleep
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Can you post the link please (the one that worked for you) or a pic of it. Looked on amazon but there is a lot of them and they all seem to have different ingidients.
i.e. see below
Modafinil — The "Rapamycin Accelerator
Modafinil users might want to ponder this. I was wondering whether modafinil affected my rapamycin dosing. Modafinil affects the AUC more than the peak. Fortunately, I take rapamycin with GFJ. Gemini says that taking rapamycin with GFJ will counter the effects of the modafinil.
Gemini:
The interaction between modafinil and rapamycin is a significant factor in your protocol because it affects both the Peak (Cmax}) and the Area Under the Curve (AUC), but it does so through two different mechanisms.
Modafinil — The “Rapamycin Accelerator”
This is a critical interaction to discuss with your longevity doctor.
- The Effect: Modafinil is an inducer of the CYP3A4 enzyme. This is the exact enzyme your body uses to break down Rapamycin.
- The Interaction: Modafinil effectively “speeds up” the clearance of Rapamycin. If you are taking Modafinil daily, your Rapamycin blood levels (trough) may be significantly lower than they would be otherwise.
- The Washout: You do not need to stop Modafinil for routine labs, but if you are testing your Rapamycin blood levels, you should tell the lab/doctor you are taking it. Note that the “enzyme induction” effect of Modafinil takes about 1-2 weeks to reverse, so skipping it for just one day before a test won’t change your Rapamycin metabolism.
1. The Impact on the Area Under the Curve (AUC)
This is where modafinil has its most dramatic effect. Modafinil is a CYP3A4 inducer. This means it signals your liver to produce more of the enzymes that chew up rapamycin.
- The Result: Your body clears rapamycin much faster than normal.
- The “Longevity” Concern: Because the drug is being cleared more rapidly, the total exposure (AUC) is reduced. You essentially lose the “tail” of the dose. While this helps with clearance, it may mean that the drug doesn’t stay in your system long enough to achieve the deep autophagy or cellular “cleanup” you are looking for.
2. The Impact on the Peak (Cmax)
Modafinil also affects the peak, but usually to a lesser degree than the AUC.
-
The Mechanism: Because your liver and gut are “primed” with extra enzymes, some of the rapamycin is destroyed the very moment it hits your system (first-pass metabolism).
-
The Grapefruit Juice Factor: Your use of grapefruit juice is actually a direct counter-move to the modafinil.
- Modafinil says: “Produce more enzymes to destroy the rapamycin.”
- Grapefruit Juice says: “Disable the enzymes so the rapamycin can get through.”
-
The Net Result: In your specific case, the grapefruit juice is likely “winning” the battle at the entry point (the gut), allowing for a high peak. However, once the rapamycin is in your blood and reaches the liver, the modafinil-induced enzymes will still accelerate its removal.
3. Summary of Effects
| Metric | Impact of Modafinil | Impact of Grapefruit Juice | Your Combined Result |
|---|---|---|---|
| Peak (Cmax) | Decreases it slightly | Increases it significantly (3-5x) | High Peak (GFJ dominates) |
| Clearance Speed | Increases Speed | Decreases Speed (Gut only) | Faster Clearance |
| Total Exposure (AUC) | Decreased | Increased | Variable/Blunted |
So, my interpretation is that the modafinil likely clears the high weekly dose of rapamycin before my next dose.
I will likely take a blood test in the near future, at the 7th day after my high weekly dose of rapamycin, to see what the clearance level is.
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How about if you don’t take modafinil the day that you’d take Rapa? In other words, do you think there is some adverse interaction if you take modafinil 24h after one has taken rapamycin. Basically, is the contradiction only when taken together/same day, or it is still present because of the high level of RAPA in the plasma even after 24 hours?
Skipping one day won’t help with the results. However at this time I like the results as I was wondering how much clearance of rapamycin I was getting after 7 days. This aligns with the protocol I want to use. High peak and almost complete clearance before the next dose.
"The Interaction: Modafinil effectively “speeds up” the clearance of Rapamycin. If you are taking Modafinil daily, your Rapamycin blood levels (trough) may be significantly lower than they would be otherwise.
This aligns with the theory:
“In the pulse dosing theory, the goal is a “mountain peak” shape: a very high $C_{max}$ (peak) to drive rapamycin across the blood-brain barrier and strongly inhibit mTORC1, followed by a rapid “cliff-like” drop to allow mTORC2 to recover.”
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I’m not sure how to send a screen shot, please tell me so I can send the picture of my great sleep aid
Thank you and I’ll try to help but I’m a bit technologically challenged sop not sure I’ll be much help. There are others here who can give way better suggestions and hopefully they’ll do so.
anyway, What i usually do is i take a picture of the product that I want to post and click on Arrow up in here that shows up when writing a message (upload button) and choose pictures and then select/click on the picture and say yes/upload.
If you have Microsoft Windows:
You can select any part or all of the screen to capture a picture.
Then paste it in your Rapamycin News comment.
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As weird as it sounds, I sleep better the days i take Moda 100mg.
Diphenhydramine and Doxylamine are both in the category of some of the oldest antihistamines available. They commonly come in 25 mg capsules or tablets and are found in antihistamine products and sleep products. Doxylamine is about twice as strong per mg than Diphenhydramine and has a half-life much longer than Diphenhydramine. If the sleep product you are looking for has only one or the other of these two ingredients then I suggest you compare to the active ingredients to these two cheap products:
https://www.amazon.com/Basic-Care-Allergy-Diphenhydramine-Tablets/dp/B074F19XB8/ref=sr_1_2_pp?crid=1PNOXLYQFGBL5&dib=eyJ2IjoiMSJ9.3IikQ5uH3pKEqkK1n85If3mmLR1NkhCKmZMrLgV3_4CQkPAtNLzwh_1k1f8WAKB-Qg2cLKl3mrQIyRd6NVY6ZTBFj-w9c2jvIeOqlNX4h8S-ujf1SA5h2EdjHNO92DQyCyiigwx_mryYPO07y0dCkChazar2oDFH0z7UoEz7gwEKzqpBJyB_oKU7jCS4JrOANNCpSOfe6vUeSjk8PTkzZvD4dcY3mzJ9x6qqoquDUyg.WzgKgGqaBY52DPQ5-tQytrnN00_qoDJLbB1OrpV4NyU&dib_tag=se&keywords=amazon%2Bdiphenhydramine&qid=1775502507&rdc=1&sprefix=amazon%2Bdiphenhydrami%2Caps%2C639&sr=8-2&th=1
Now, the bad news is that both of these antihistamines may have some influence on bringing on earlier Alzheimer’s. Having said that I am not concerned because I suspect that many prescription sleep supplements may do the same, but they have not been researched for this. I commonly use Diphenhydramine 25 mg before bed and another 25 mg if I wake up between 1:00 am and 2:00 am. I recover easily from this in the morning with coffee and exercise. I avoid Doxylamine because although it will likely give better sleep I don’t like the hangover effect in the morning. So, I take the lesser of the two evils. As I’ve mentioned elsewhere you can always use Modafinil to overcome any lingering foggy brain in the morning, but that means one drug for sleeping and one drug for staying awake. But, if you need to sleep then from my experience these seem to be kinder than the prescription drugs.
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