Confused about rapamycin half life

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hello everyone :slight_smile:

…i know this topic has been beaten to death, and i’m sorry to bother everyone by asking about it again,

but i am so confused about the half life of rapamycin …and when it is “okay” to resume my supplements after having taken it -

i only just read about a half life of “63 hours,” and also i think i read (forgive me @rapadmin if i am misquoting you!) maybe @rapadmin had said “you” should even wait “3-5 half lives” ? (:flushed:) -

but, maybe, that was “for the drug to be mostly out of your system,”

NOT necessarily just to resume supplements?

…but i have read of some users just not supplementing on the day of, and the day after, as well, that they had taken rapamycin -

so i am confused, because, for me it’s not just that i’m trying to get the benefit of the rapa (and/or supplements), but …i’m broke, and i’m scared i could be Wasting The Money, either for the rapa, or all the supplements, of BOTH :frowning: -

welcoming weigh-ins, on whether i should wait an additional day at least, before resuming supplements -

or other possibilities… -

currently, i STOP my supplements on THURSDAY MORNINGS

(i’ve tried to look up THEIR half lives, and they don’t seem too long -

*** but now i’m confused, whether i need to, or “should” wait at least 3 half lives, maybe 5??),

and then i take rapa on FRIDAY NIGHT, 6PM,

…and resume supplements on SUNDAY AT 6PM (48 HOURS) -

because i’ve been wanting the benefit of the supplements -

but now i fear i am blunting the rapamycin, too soon :frowning:

(also, i wanted to ask,

specifically,

does anyone know if it’s okay to take

VITAMIN D

still on the days i take rapa?

…and how about “minerals”?

or fish oils??

vitamin d especially, is important to me,

but i’d like to be able to take at least fish oils,

and maybe some minerals…

…oh, and i forgot about:

METFORMIN?

and, liothyronine?

would metformin be, possibly beneficial to take on same days as rapamycin?

…but liothyronine, i have no understanding about, and definitely hope to hear from others who knoe more than me!)

…sorry, all, for the post on a topic that’s been run into the ground…

thanks, all! :slight_smile:

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The basic idea is not to inhibit or shorten bioavailability of rapamycin, by such supplements like curcumin/turmeric - this particular supplement enhances the enzyme that metabolizes rapamycin so should be avoided a few hours before and after rapamycin, so if you avoid taking, for simplicity’s sake the day of and day after rapa you should be fine.

There are also supplements and foods such as grapefruit and grapefruit juice
which inhibit the enzyme that metabolizes rapamycin. If you take that within a few hours of rapamycin, you will in effect multiply the effective dose of rapamycin - which you may or may not want to do. If you eat fat while taking rapamycin you also prolong the serum presence of rapamycin, which you may or may not want. For simplicity’s sake so that you know exactly how much you are taking, take rapamycin on an empty stomach and don’t eat or drink anything other than water for 2-3 hours after taking it.

There are also drugs and supplements which may work at cross purposes with rapamycin, such as mTOR activators, such as taurine. However the thinking is that rapamycin inhibits mTOR directly and simply renders activators ineffective. For simplicity’s sake you may want to avoid taurine on the day of and the following day. Rapamycin may also render drugs or supplements less effective, such as astaxanthin, so avoid asta on the day of and day after.

Vitamin D doesn’t seem impacted either way, so don’t worry about it. Same for fish oil and minerals (maybe caution with zinc?). Liothyronine doesn’t seem to interact with rapamycin, so I wouldn’t worry about it - you can check for drug interactions on drug.com. Metformin might even be synergystic with rapamycin so I wouldn’t worry about it.

If you search this site, there are threads which address these very topics - food and drink interactions with rapamycin and drug interactions.

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this is a credence buy you have any other way off to bed early and all my heart to do is get up at like flu

Metformin enhances absorption of Rapamycin as well as blunting the negatives of Rapa. The two drugs are highly synergistic and should be taken together.

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@vongehr …i don’t “have anxiety,” there is just a ton of conflicting information ; plus, i don’t have the intellect to understand the more scientific stuff… ;

…THANKS SO MUCH @CronosTempi and @DeStrider for your very helpful answers,

even advising about metformin, liothyronine, vitamin d, fish oils, zinc

…and taurine, which i take too (and separately, i also take “tudca”), and was not aware that it might interfere with rapamycin ;

i will stop taking the taurine, the morning before (2 days before, because i will take rapa the next day AND at night) -

also, ASTAXANTHIN, which i had forgotten about, i will now stop taking 2 days before

(and i have ***STOPPED curcumin, too. feel it is a shame, because i thought it could do such good for my body ? …but don’t want to risk it interfering with rapa - or harming my liver, God forbid!) -

but vitamin d, fish oils, liothyronine, and metformin i am happy now because i will tale every day :slight_smile:

thank you so much for helping me sort all this out! :slight_smile:

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Hi, and welcome to the site.

I keep my supplement list quite short to keep things simple (and not too expensive). If you have any supplements that impact rapamycin, then just skip those supplements on the rapamycin dosing day.
See: Rapamycin Interactions with Other Food, Drinks, Supplements and Drugs

At minimum, I also eat a fatty meal prior to dosing rapamycin (sardines in my case): Improve Bioavailability of Rapamycin (2)

I avoid Grapefruit juice because I take a statin that is affected by grapefruit juice (so I want to avoid the interaction).

I recommend reading up on different supplementation strategies, but if you want to save money avoid most of them (most provide minimal benefit other than if you are deficient).

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@RapAdmin thanks for always taking the time to respond :slight_smile:

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" am confused …and having actual anxiety …because"

never mind

@vongehr i said i “was having” anxiety …because, Understandably, with all the conflicting information, i didn’t know what to do -

i don’t “have anxiety,” as in, a mental health issue,

and your initial response was judgy… ;

i have removed the confusing statement from my original post

Matt Kaeberlein discussed half life on his YouTube channel about 8 months ago. the 63 hours was apparently derived from higher dose transplant patient data. Matt tested himself and got a much shorter half-life. He also showed data from Bryan Johnson who also had a shorter half-life (less than a day). Suggestive, not conclusive, that 63 hours might be taken with a grain of salt.

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For sure, rapamycin does NOT stick around for a 63hr half-life in healthy people using it intermittently.

Here’s what I know so far based on data we’ve collected at AgelessRx (we check everybody’s sirolimus levels but at random timings - we let people get their blood drawn whenever is convenient rather than time it for rapamycin):

  • sirolimus levels seem to peak around 2 to 4 hours after ingestion
  • there is a much smaller peak around 48 hours
  • levels drop off around day 4 or 5
    This is based on my observations of reviewing patient charts. I asked my research staff to see if we can analyze the data and make more concrete conclusions

Personally, I take my rapamycin on Tuesday around 1pm - maybe 30min after lunch.
I wait another 30min and take my other afternoon meds/supplement. Including 2.5mg tadalafil, 10mg atorvastatin, and a small dose of sublingual tirzapatide.
I avoid anything with curcumin on Tuesday since it’s thought to interfere with absorption.
Otherwise, I take my normal meds/supplement stack in the morning. This includes 1000mg of metformin ER.

Is it optimal? I have no idea…

But I recently did a metabolics test by Iollo (Mike Snyders group) and my rate of aging was very low (0.05 - whatever that means)

No, I haven’t done a Dunedin-Pace test recently to compare. Sorry

Remember , though, what works for me may not be appropriate for you!

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My high dose testing did seem to fit, however, with a long half life. It is quite likely a two compartment system anyway.

I did not, however, test for serum half life. Instead I tested for blood panels twice a week. The effect on Neutrophils is quite rapid. (because they have a really short half life).

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NGUH, I’m just commenting to give you support!

I find all this information hard to digest as well!!! Because I don’t have a brain for science either, I rely on everyone’s help to figure it all out, so I’m glad you posted your question!

And PS, I don’t accept that you have lack of intellect… our brains are all wired differently and we have strengths and weaknesses in different areas. I’ve met brilliant CEO’s who can’t fight their way out of a paper bag :slight_smile:

And yes, the amount of money one can spend on all these supplements is staggering, so I understand the financial stress of it all. You are very smart not wanting to be wasteful.

I’ve learned some things from the answers here, so thanks again for your post.

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Big part of the confusion here seems to be that the half life itself is what varies between people and methods such as grapefruit (GF) ingestion.

It is not so that GF by some magic multiplies Rapamycin, and then comes the independent half life. Instead, and this is why I keep eating GF for a few days, GF slows hepatic removal of Rapamycin and thus increases the half life, especially soon after dosing in oral or rectal applications (because the blood from those places first goes through liver), but also later (blood always still hits the liver once in a while, even if you dose IM).

I agree with you that GFJ will also increase the half life. However, personally I don’t want to increase the half life.