I worry about this. The LLM presentation is so good we forget it’s GIGO all the way down. Garbage In, Garbage Out.
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I pair my 6mg weekly pulse dose of Rapamycin with microdosing Tirzepatide as it protects and improves beta cell function.
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I’ll check my last HB is 137 g/L or 13.7 g/L last month. Historical ones are below:
It appears that since I took rapamycin, my RCC (red blood cell count) has improved. For reference I started in Feb 2024.
I thought Attia does 8 weeks on and 6 weeks off …or something along those lines unless he updated his regimen.
Another point to be mindful is that their dosing is based on their body weight. I am sure readers of this forum are sophisticated enough to realize that.
Great compilation BTW! Didnt realize Deepak Chopra belongs to the club too!
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Speaking of GIGO, there are folks out there (idk organized or not) that actively feed LLM with misinformation with intention of polluting the algorithms and output.
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Yes, the list has not been updated for awhile. This is the latest I heard from Peter Attia. If you have a newer source please let me know.
Here is also one interesting summary I did a while ago when it comes to body weight.
Source: https://x.com/KristerKauppi/status/1663482129022431232
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Thank you for the updated information. It doesn’t look like it has changed much. I started cautiously with 2mg weekly and then slowly ramped up to 6mg with two to three week breaks every 3 to 5 months. I have not noticed any negative effects. I have noticed before my Rapa regime, I would experience minor cold or flu episodes 2 to 3 times a year. Since I started Rapa I only had sinus like cold symptoms twice in the last 2 years.
Our bodies are incredibly complex. Everyone a bit different. I am comfortable being part of this new longevity experiment and continue to be hopeful Rapa will eventually seen as a important part of our evolution.
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Do you take Tirzepatide to protect pancreatic islets only or to deal with DT2 (and weight management)? Wondering if it could work for somebody who doesn’t have diabetes.
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That’s either really impressive, or I worry about what you were like at age 17.
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Okay, you scored a point. I took it to mean he is now motivated to stop all the stupid behaviors and start the good behaviors he always knew he should do. …and the results are pouring in. I thought, “nice work!”
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Good point, and it got me thinking.
Your right, at 17 I was faster, more agile, taller, and no wrinkles. I was probably in the 75% range of physical shape in comparison to my peers.
Now I am 70 I am slower, shorter, growing wrinkles, but also much more muscular. The goal now is to be healthy, keep active, and to be as robust a I can be for as long as I can. From that perspective, at present I feel I am in the 95% range of my peers.
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I am 66 yo, and at work see plenty of people in our age range that are in horrible health, mostly due to not taking care of themselves. Not sure if I should give any credit to Rapa for my reasonably good health.
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In a podcast with Matt Kaeberlein… he said he was cycling his rapamycin dose… and then just stopped cycling after a few years.
Of course, like me…
always tweaking and checking biological markers… from 6 mg weekly my first 1.5 years to then higher doses tripling it… then lower doses 4 mg weekly… I have come back to 6 mg past year… considering upping to 8 mg weekly as I turn 67 years and start my 6th year of use in August.
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I took it to reduce visceral fat and weight management. I paired it with Osterine to maintain muscle mass. Worked brilliantly. Now microdosing for a variety of health benefits: cancer prevention, reduced inflammation etc…
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@Walter_Brown are you still taking ostarine? I think you mentioned in the past you cycle it. Have you noticed it lowering your LH and FSH levels?
Yes, I am still microdosing. My free testosterone levels came back as low.
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I have been on 5mg/week sirolimus dose since last 8 months (with wash out periods every few months). When I take this in combination with Rosuvastatin 5mg, I have experienced glucose dysregulation (more pronounced glucose spikes post-meal as seen on my CGM, and HBA1C increased from 5.2% to 5.8%).
Background:
- My activity level is high (12k steps/day, 4x weekly gym,1x weekly cycling, etc)
- Clean diet
- 14 hr daily fasting window
- Good sleep hyegine
- A handful of supplements (which I mostly keep constant)
- Fasting insulin 2, and Fasting glucose 90 mg/dL when last tested, which suggests very low Homa-IR of 0.44
- Sirolimus 5mg/week, with occasional washout periods (chosen at random)
- For lipid management, I currently use Bempedoic Acid + Ezetimibe daily, with which I can achieve Apo(B) level around 65mg/dL, with no impact on liver/kidney function, and no impact to glucose. If I add Rosuvastatin 5mg to this, I can get Apo(B) further down, however it seems to impair my glucose homeostatis.
- I’m not on metformin on a daily basis. However, I did occasionally take metformin, like once a week or during cheat meals (as an experiment), and found that it does nothing for me (which is expected, since you need steady state metformin levels throughout the week, for it to work)
I haven’t quite worked out if sirolimus alone or rosuvastatin alone or this particular combination is causing my glucose dysregulation.
Example below. I had Sirolumus and rosuvastatin in the morning (note I had a 3 week washout period for rosuvastatin prior to this date). The same day, I finished dinner at 6pm (Mexican naked burrito, which includes brown rice and beans). Each time glucose spiked, I walked and it came down, and this zig zag went on for 5 hours!
Analysis 1: When I read Chris Masterjohn’s article, one point resonated with me - Rapamycin inhibits glucose oxidation. So, my speculation is that inhibition of glucose oxidation kept my blood glucose elevated, while my periodic walking/movement was trying to shuttle glucose back into the cells. This conflict between the two was potentially causing this zig zag spike pattern for me.
Analysis 2: I queried chat GPT - Weekly 5mg sirolimus vs daily rosuvastatin 5mg. Which one is more likely to cause hyperglycemia or glucose dysregulation. Below is what I received.
So I guess I need to isolate the drugs one by one and do some more testing. My goal is HBA1C = 5%, Apo(B) < 60mg/dL, and leveraging sirolimus for episodic mTORC1 supression, and trying to achieve these 3 goals without any impact to liver/kidney function.
Would love to hear the forum’s views on this, and any similar personal experiences.
Thanks
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Sorry for being thick. But could you explain what your reasons are (“for reasons I explain further down below”). I must have missed the explanation or I’m not understanding.
If you look at my second high dose
You will see the effect of an admittedly high dose on the feedback systems for glucose. Because I have long periods between rapamycin I think I see my glucose feedback system stabilising before rapamycin knocks it off balance again. I don’t think it is an immediate thing, but happens after a couple of days and because initially of hepatic insulin resistance and then the other systems over compensate and it ends up with a period of really high insulin responses without the insulin resistance.
I will do another CGM session before I use rapamycin again.
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I’ve been doing the same combo of rapa and rosuvastatin and it also raises my A1C. I’m taking a hiatus from Rapamycin for the time being to see if it improves the A1C.