Thanks for posting your great stack!
Not medical advice…
To me it appears that you have too much gaba raising stuff and glutamate (nmda) & catecholamine (dopamine/noradrenaline) lowering type stuff. Maybe even raising adenosine if you don’t drink coffee or take caffeine. Perhaps lowering cortisol, etc.
So, you might want to play around with when you take supplements, so daytime vs night time.
Could consider adding in tyrosine powder in day time like 1g to 5g. This will balance out your other aminos like taurine(which is more calming).
Or you could get a medication like modafinil, ritalin, wellbutrin, some type of reuptake inhibitor, Beta 2 agonists like salbutamol, or whatever RX your doctor and you are good with.
AMPK is a good pathway and I figured you should already be targeting it with your stack.
Metformin perhaps?
Forskolin extract 10-20% supplement is pretty cool in regards to boosting thyroid levels, and cAMP levels. Which might boost energy and mood etc.
Things that would lower catecholamines or slow my day time energy down from your stack (at least from what I’ve tried) would be the high dose magnesium, 12mg astaxanthin, taurine, creatine, progesterone, LDN, melatonin high dose, maybe some of the stuff I’ve never tried that’s in your stack.
Wow, you put much more time into this than I had expected, so thank you!!
I’ll do some googling to try to absorb some of these new concepts/terms you’ve shared, and I might pm you with some follow ups.
I drink two lattes every morning, so roger on caffeine
Regarding ritalin. Aprox 20 years ago I was on adderall for aprox 3 months for my ADD and it was the BEST 3 months!!! Clouds parted and angel sang… but alas, with heart disease, I was told it’s nothing I should mess with… I’m fully functional without it, so I don’t push it.
You mentioned some things that might bring my energy down, and ya know, maybe that is why, for the first time in my life, I sleep like a baby!! Life long insomniac until rapa came along… .and as I added more and more things, it kept improving (LDN was a huge add).
On playing with timing… funny you say that becasue I now have something I can try… I was taking taurine before bed, and recently I switched to powder form intead of capsules and am now taking it in my earlier powder mix… the only reason I did this is because there is so much talk here about not taking glycine and taurine together… Maybe I’ll try adding it back at the end of the day, again, to see if that could help.
You also mentioned magnesium. I was taking a mag supplement that contained malate and glycinate, but then I replaced it with two separate mag pills, and after reading malate might be good for energy, I then started taking the mag malate early in the day instead of before bed.
I’ve just been prescribed Flomax and 5mg finasteride for my enlarged prostate. It is 52cc and I’ve had a TURP some years ago. Ypu seem to do okay on it.
We all have a very individual biological construction. For me, taurine can provide both daytime energy and nighttime relaxation/sleep. I take it for energy as well as to improve sleep during the night.
When I wake up during the night, I take 2-3 grams of taurine and it is a reliable way for me to slowly go back to sleep. When I take 5-7 grams of taurine in the morning, then after 90-120 minutes, I get a rather long-lasting boost of energy. I have tried to find an answer to these bi-directional, context-dependent physiological effects. For me, taurine is a mild energizer during the day and a relaxant/sleep aid at night. ChatGPT has given me a few clues:
GABAergic & Glycinergic modulation: Taurine acts as an agonist at GABA and glycine receptors, which has calming, sleep-promoting effects.
Glutamatergic balance: Taurine can also inhibit overactive glutamate transmission and reduce NMDA receptor excitotoxicity, stabilizing neural activity. which can improve sleep quality but also sharpen daytime mental clarity.
Mitochondrial & Cellular Energy Effects: Taurine conjugates with mitochondrial tRNA and supports efficient oxidative phosphorylation. During the day, when energy demand is high, taurine supports mitochondrial ATP production and neural firing stability, which can be perceived as a steady “clean” energy boost after 90–120 minutes (time for absorption and mitochondrial integration).
Thank you for sharing. BTW I tried C60 a few years ago and I am curious to hear about your observations.
Pretty much have taken 5 mg nightly… for 33 years or more. Started with proscar…for my hair retention then, went on generic finasteride. Never had any ED issues. Started tadalafil about 4 years ago… to open and relax all veins. Libido and ability great… typically get off morning and night.
As a long term user of finasteride, my prostate remains walnut size… is a prostate cancer prevention medication, clears cholesterol from the blood, and yeah still have my hair… going on 68 years.
Updated my avatar this week… just incase anyone noticed.
Nandrolone decaonate and I haven’t had any of those issues at 200mg or less
75mg-100mg is probably the good safe amount for indefinite use but that’s an educated guess form doing a deep dive on it. 150mg could be safe too but I think the joint benefits are the same at 100mg. Of course no one who isn’t on TRT should consider this.
That’s what I do for a few weeks now (tendinopathy). I dissolve the collagen in a black coffee, it does not taste anything and gives me some caffeine before training.
30g Peptan collagen, 480mg vitamin from BerryPlus, and 20mg tadalafil.
This seems closely related to Dr. Keith Barr’s work. I stumbled on a reference in a post here on RN. Barr’s field of study examines how tendon, ligaments and joints can recover from injury, using isometric holds. He is also a molecular specialist and this where collagen (gelatin) and vit c comes in. I used his approach to deal with knee pain and calf injuries. And it worked well beyond my expectations. I used the vit c / collagen dosing prior to doing the isometric rehab work, but expanded the dosing to other activities like strength training, skiing, and sprints. It just seems logical. I highly recommend Barr’s field of study if you want to bullet proof your active joints.
Of the last two stacks posted, one takes Ezetimibe in the morning, and the other takes it in the evening.
Is there a best time to take it or doesn’t it matter?
From what I see on the internet the evening is favoured as the body supposedly makes more cholesterol at night.
Bodybuilding cycle, the quantity are per day.
At low dose (140mg weekly) I do not have any physical sides effects and trenbolone works mostly as a SARM in the muscle with high anabolic property. There is also a beneficial blockage of the GR and MR lowering hugely the muscle catabolism.
Boldenone is here to lower estradiol level to a physiological level
Testosterone to build muscle, same for oxymetholone.
What benefits are you finding from exogenous DHT? I started recently and it has improved sexual function dramatically, and has improved general confidence.
Wow.
I’ve wondered what a subQ micro dose of trenbolone might do.
It’s so good. Experiencing it settles the argument for me that DHT isn’t a “trash hormone”, it just feels so damn good. A lot of men need it to fully optimize their hormone replacement therapy. Now if we could just fix the negative effects on the hair and prostate we have something really powerful.
