I did bodybuilding from 10 years in the past and I think long term, it’s better to do two 8 week cycles with 8 weeks off /TRT then 16 weeks straight. You should definitely check your liver enzymes every month.
I don’t think from bodybuilding I “hurt” my body biochemically but I did hurt my lower back from deadlifting and caused shoulder arthrosis from training to heavy… So make sure you don’t cause any damage like I did…
1 Like
I’m definitely interested in how this goes since you’re taking so many things to prevent delirious health effects. I occasionally still do a cycle but it’s never anything crazy anymore.
2 Likes
Glp1? I just finished a cut and I’m doing a bulk, but not at the level you are. I feel good for the most part.
Yes, tirzepatide. Started at 5mg and finished at 20mg, then dropped the dose to 2.5mg to back. I stopped it and I’m taking retatrutide. I planned to stop it too, low dose doesn’t seem to be beneficial that much, too much GIP activation
20mg! Man you go hard on this stuff haha. I went up to 7.5mg Tirz, I’ve lowered to 3.75mg for maintenance. I might try reta in the future.
The less weight to lose you have, the higher the dose you need to take. I was feeling great at 20mg.
1 Like
What is the reason for that?
That’s how it works!
You’re at 120kg, and take 2.5mg, your weight drop to 110kg. Now, you don’t feel appetite suppression.
You go up to 5mg, and your weight drop to 100kg.
Then you go to 7.5mg etc.
2 Likes
It’s funny because the prescription for GLP-1 differs. The longer you take it, the lower the dose prescribed. But makes sense that you would need more…
That doesn’t make any sense, GLP-Ra are like a hormone remplacement therapy, when you achieve the desired weight or anti-diabetic level you wanted, you stay at that dose, indefinitely. Some people go to high level of the drug, some need less.
2 Likes
Does growth hormone give you fluid retention at all? Anything you take to combat this?
Not at all. Estradiol is controlled to begin with and I take eplerenone 50mg, indapamide XR 1.5mg and amiloride 10mg in the morning and 10mg in the afternoon.
1 Like
Kamil Pabis, longevity researcher in Bryan Kennedy’s lab at NUS in Singapore, posted his stack below. I think he’s in his early 30s… so still early in the aging ramp.
I am sure some people are wondering how does the “health stack” of an actual longevity scientist - a youngish male - look like. The end of 2025 is certainly a good time to take stock and review what we did and why. Below is an updated health protocol for 2026, which represents my current stack with very minor tweaks. But before we get into that, perhaps a few words about longevity science, blogging, health and the future of human progress.
First of all, a healthy diet and supplements won’t substantially affect aging. My hope is that, one day, humans will be able to stay young forever and cure aging so that people can choose their own fate. Fair is fair. If you share the same dream you should contribute to longevity science by donating to moonshot projects like Impetus grants or combinatorial mouse screening, founding or funding start-ups, or even becoming a researcher or policymaker.
Whether we are at all closer to this goal of radical lifespan extension remains debatable. There have been many breakthroughs during my lifetime, yet aging remains as formidable an enemy as ever. To name two, rapamycin showed that a drug can extend the lifespan of healthy mice even started in late middle age. GLP-1 receptor agonists showed that there is a way to both tackle the obesity pandemic, and test crude CR mimetics in humans, with mixed success so far. In fact, my hope was that the first approval of a real longevity drug, even if very primitive and impotent, would lead to an exponential increase in funding towards the development of new drugs. This has not happened so far.
However, talking of exponentials, we did see an explosive growth in AI investment and data center buildout. My current hope is that human-level artificial intelligence will be able to tackle many of the problems the field faces through sheer scale of intelligent brute force - imagine what we would find if we could screen a million drugs for lifespan extending effects in mice because labor, land and energy became cheap enough to allow this thanks to automation and AGI.A healthy diet by itself will not get us to radical lifespan extension. That is why I remain committed to doing aging research, both translational science directed towards age-related disease, and basic science in the form of comparative biogerontology, and also in the form of lifespan studies in mice.
Nevertheless, I think that biohacking is important, albeit less so than frontier aging science. It fuels the ecosystem by injecting money into both research and relevant companies; it attracts new people; it is highly addictive; it enables research e.g. in the shape of observational studies of CRONies, rapamycin-users and health enthusiasts; and it DOES have small health benefits. Regarding health and biohacking my views can be summarized as “holistics”; drugs and supplements are often under-rated while exercise and diet are often overrated as drivers of health. Ultimately, all of them contribute and at this stage it is impossible to say which one is most important.
5 Likes
He says all the right things, but his stack is surprisingly (to me) pedestrian, with some of it what I would consider “fluff”. Interesting of course, but (again, trying not to be judgmental) somewhat shallow (to me) reasoning as coming from a researcher in the field. But definitely says the right things about what moves the needle and what not, the excessive hope for diet and exercise compared to molecules potential, necessity to focus the research effort and need for personal dedication and contributions from longevity enthusiasts - all I could happily co-sign. YMMV.
4 Likes
Appetite is a limiting factor unfortunately, even without GLP1.
I’m currently at 83kg, weight is hard to gain.
I dropped GH i was becoming narcoleptic
Might start again at really low dose and not before sleep.
1 Like
I’m surprised you could experience narcolepsy on modafinil and that many anabolics.
Gh is really sedative at high level (8UI+).
My sleep quality is bad (intense snoring, sleep apnea). If I’m not stimulated, I fell asleep (at the barber it happened, while on the car, the train, or juste at a break at work.
1 Like
All of these anabolics are worsening your sleep apnea you know? They thicken the muscle around the neck.
1 Like