I am not about to criticize anyone’s stack unless I spot something very dangerous. We are all on our own self-discovery to find the things that work best for us. We have noted from many posts that things that work for one person don’t work for another.
I am always trying to keep my stack as small as reasonably possible without missing out on a major intervention.
Old men (84), like old cars, generally have a lot of things that need fixing.
This is my current list of supplements and drugs that I have chosen for my personal needs and not a recommendation for anyone else, especially younger people.
I have eliminated many supplements I have taken in the past to reduce the list to a manageable number.
You may wonder why metformin is not on my list. I took metformin for decades, and I am a believer in its efficacy. Unfortunately, I reached an age where my gut no longer tolerates it, even in timed-release form. Statins? I just feel better when I am not taking them, and I have been taking substitutes that keep my lipids in order.
These are the supplements/drugs that I am currently taking.
As you can see, it is heavily weighted towards cognitive benefits. Losing one’s mind is an old person’s worst nightmare.
These are the supplements that I have been taking on a regular basis:
CoQ10 Cardiovascular health
Vitamin D3 Cardiovascular and immune health
Vitamin K2 (MK7) Cardiovascular health, preventing arterial calcification.
Lithium orotate Cognitive health, life extension
Magnesium L-threonate Cognitive function and sleep.
Alpha GPC Choline: Cognitive enhancement
Bacopa monnieri Cognitive function, stress reduction, memory support
Ginkgo Biloba Cognitive function, circulation, brain health
Phosphatidylserine Cognitive function, stress reduction
Creatine Cognitive function, creatine has neuroprotective effects. Prevention of muscle loss. Creatine may help regulate blood sugar levels.
Galantamine Cognitive function By increasing acetylcholine levels, it can help enhance memory, attention, and the ability to perform daily activities.
L-citruline Nitric oxide production, improve circulation, reduces blood pressure
Boswellia serrata Boswellia serrata exhibits a broad spectrum of therapeutic benefits, particularly in managing chronic inflammatory conditions and supporting joint health. Reduces hsCRP
Drugs:
Metoprolol Helps lower blood pressure, reducing the risk of stroke, heart attack, and kidney problems.
Telmisartan Lowers blood pressure, improves heart function, reduces the risk of stroke, improves insulin sensitivity, and improves the function of blood vessel linings.
Dutasteride Reduces symptoms of BPH and possibly reduces the risk of developing prostate cancer
Tamsulosin Improves urine flow
Tadalafil Tadalafil helps relieve symptoms of BPH. Tadalafil is approved for treating pulmonary arterial hypertension by relaxing the blood vessels in the lungs, which improves blood flow and reduces the strain on the heart, thus improving exercise capacity and quality of life. PDE5 inhibitors like tadalafil may promote autophagy. PDE5 inhibitors have been shown to protect against cognitive decline and support brain health, potentially influencing aging-related cognitive decline. Preclinical studies have suggested that PDE5 inhibition may improve mitochondrial function, leading to better cellular energy production. PDE5 inhibitors, such as tadalafil, may have anti-inflammatory effects, which could contribute to improved healthspan and longevity.
bempedoic acid/ezetimibe (combo pill) Enhanced LDL cholesterol reduction. Greater reduction in LDL cholesterol than either drug alone. Lower risk of new-onset diabetes compared to statins.
My life extension supplements/drugs (unproven as yet)
Rapamycin ~15-20 mg effective dose weekly.
Lithium Orotate 10mg daily
Melatonin 10 - 1000 mg. nightly.
Tadalifil 5 mg daily
2 g = not enough NO → tadalafil has nothing to extend synergetically