What LLM did you use?
Gemini 3 fast
Association of SGLT2 Inhibitor With Stroke in Type 2 Diabetes With Diabetic Retinopathy: A Multicenter Electronic Health Record Data Study
https://dom-pubs.pericles-prod.literatumonline.com/doi/10.1111/dom.70744
3 Likes
Henagliflozin extends telomeres. Could apply to all SGLT2’s. Interesting stuff
13 Likes
My doctor has a good thing to day about dapa.
Henagliflozin (a newer, primarily Chinese-marketed SGLT2i) and dapagliflozin (a widely established global SGLT2i) provide similar HbA1c reduction and weight loss in type 2 diabetes. Both agents improve glycemic stability; however, dapagliflozin has broader, extensive evidence for reducing heart failure hospitalizations, while henagliflozin may have a higher rate of adverse effects at certain doses. [1, 2, 3, 4, 5]
It is also being studies for longevity at UoT
https://x.com/davidasinclair/status/2029715732280566203?s=20
6 Likes
Just noticed that CostPlus has Dapagliflozin Propanediol (Generic for Farxiga) for $15.07/90 pills ($0.17/pill)
10 Likes
Frailty, Not Age, Drives Risks With SGLT2, GLP-1 Drugs in Older Adults
Cardiometabolic drugs such as SGLT2 inhibitors and GLP-1 receptor agonists offer substantial benefits for older adults, but clinicians should base prescribing decisions on a patient’s frailty and comorbidities rather than age alone, experts said at the American Geriatrics Society (AGS) 2026 Annual Scientific Meeting.
SGLT2 inhibitors are linked to side effects such as genital infections, dehydration, and dizziness, which may increase the risk for falls in older adults. GLP-1 drugs often cause nausea and weight loss, which may be harmful in patients already at risk for frailty or muscle loss.
“The key thing is that risk is vulnerability dependent, not age dependent,” said Chintan Dave, PhD, associate professor of pharmacy and epidemiology at Rutgers University School of Public Health in New Brunswick, New Jersey.
6 Likes
Without knowing facts, I will stick up for her.
She has always been rail thin with no detectable body fat. My guess this is just how her skinny face is naturally aging.
She could make her face look different if she used filler, but then people would critique her for that… so…….
2 Likes
Has this study been posted on the site? Search doesn’t come up with it.
Effects of the SGLT2 inhibitor dapagliflozin in early Alzheimer’s disease: A randomized controlled trial
3 Likes
Posted here in April 2024 (yes, more than a year before the actual publication date) by yours truly 
Canagliflozin - Another Top Longevity Drug - #750 by adssx
7 Likes
Rats, that’s why the title didn’t come up in search. That was before I joined the site in August of that year. I should have known, no way would you miss an RCT involving dapa and dementia. The study is small, and short duration, but still somewhat interesting.
3 Likes
Yes, multiple generics now approves in the US as of April, see eg
5 Likes
Just want to confirm that I was able to get a 3 month supply of Dapagliflozin, 10mg for a total of $30 with express shipping. Would have been $15 with regular shipping.
11 Likes
For those who take resistance training seriously: how have SGLT2 inhibitors affected your progress in muscle strength and hypertrophy? Are you doing anything specific to minimize potential negative effects besides the basics like maintaining high protein intake and training regularly?
It didn’t change anything for me
I have hard time understanding this study (I’m sure I’m missing something). Why would placebo group have a 65% increase in telomere, that is huge? and how was it measured? I’m assuming it was a before and after measurement, or probably it was compared to a controlled group of random (other) people?
I mean what the heck if placebo gives an increase of 65% might as well take the placebo? Unless I’m missing something, this is very weird. I mean I’ve seen placebo have say an effect of 10% on other studies but 65% is HUGE. As it stands right now, I have zero confidence in this study. You don’t just feed people corn starch/placebo and all of the sudden their telomeres lengthen by 65%.
1 Like
I switched from metformin to an slgt2. I am a 53 year old male and I noticed no difference in strength or muscle size. That said, I am much more veiny. Keeping fat off always take work but it is less work with an slgt2. I get lots of compliments on my low body fat percentage at the gym and in public.
3 Likes
Hormone replacement therapy would offset this imo. Same with muscle loss on GLP1s.