Anyone know if this is legit and you can indeed get real Paxlovid from Indiamart? Would be great to stock up in advance of a future COVID infection.
2 Likes
Similar to the quotes I got recently, I think I am better off just increasing rapamycin dose than switching over. The main reason I wanted to switch was to get more of it into brain (for cfs), but a larger dose of rapamycin might offset the difference anyways. With rapamycin it is easier to boost as well (high fat and such) but with everolimus I dont think the same boosters work
1 Like
Everolimus is impacted by the same CYP3A4 enzyme so you’d see the same benefit in bioavailability.
From ChatGPT:
Yes — everolimus is metabolized by CYP3A4 (and transported by P-glycoprotein), so grapefruit juice has the same kind of interaction risk that is well described for rapamycin (sirolimus):
Metabolism pathway: Both rapamycin and everolimus are mTOR inhibitors extensively metabolized by CYP3A4 in the liver and gut wall and are substrates for P-glycoprotein efflux.
Effect of grapefruit juice: Grapefruit juice inhibits intestinal CYP3A4 and P-glycoprotein, which increases oral bioavailability and systemic exposure. For everolimus, pharmacokinetic studies show grapefruit juice can raise plasma concentrations significantly (sometimes 2- to 4-fold increases in AUC), very similar to sirolimus.
Clinical guidance: The FDA label for everolimus (Afinitor, Zortress) explicitly instructs patients to avoid grapefruit and grapefruit juice because of the risk of elevated drug levels, leading to increased toxicity (e.g., mucositis, cytopenias, infections). The same is true for rapamycin labels.
Magnitude & variability: The degree of increase depends on the individual’s CYP3A4 activity and the amount/type of grapefruit consumed, but in both cases the interaction is clinically significant and unpredictable, which is why avoidance is strongly recommended.
Bottom line:
Everolimus is indeed affected by grapefruit juice through CYP3A4 inhibition and P-gp interactions, just like rapamycin. Patients are advised to avoid grapefruit products to prevent dangerously high blood concentrations.
1 Like
If you’re buying the version of the drug manufactured by a reputable Pharma company (e.g. Pfizer, or the list here Generally Good Indian Pharma Companies
the answer is probably yes. But right now all shipments have been halted from India due to the tariff war, so we’ll have to see if / when things open up again.
1 Like
NOOOO! This is life or death for me as I’m also buying a lot of off-label pharms to treat Long COVID. Are there any alternatives from other countries?
Looking to buy:
paxlovid
sirolimus / rapamycin
maraviroc
statins
aciclovir
See these threads:
1 Like
Anyone order recently and had to pay a tariff from customs?
I look forward to hearing from someone who has completed the process…
1 Like
I just got this response asking Rapashop about their shipping, I have never used Rapashop before but it was recommended to me:
We are shipping from India, but unfortunately, we have been unable to fulfill orders to the US since August 25th. To keep customers informed, we have added a pop-up notice on the cart and checkout pages.
SingPost (Singapore) and AusPost (Australia Post) have implemented a system that allows taxes to be collected at the time parcels are processed in the originating country. With this system in place, they are expected to resume deliveries within this week.
Similar integrations are underway across other Postal Union members, and we anticipate being able to resume shipping to the US in the second half of October. Since pharmaceutical products were originally exempt from tax, we do not expect any significant increase in overall costs.
This sounds somewhat hopeful!
I keep checking AllDayChemist for updates as well but it’s been the same.
3 Likes
Did you receive the order in the meantime?
I have also an open order from August 24th and got never a reply to my emails about an update.
No I didn’t! I also know someone else who placed an order from BGpharma in September and never heard back.
I used BGpharma for a few medications over the years because I didn’t want them in my medical records. I found the guy quite reliable, although sometimes he’s slow to respond and deliveries take longer than expected. In short, I would be really sorry if they became unreliable. Didn’t you @A_User order from them too? Have you had any experience recently?
I have just received some Zydus and some Biocon from Gandhi Medicos who have been reliable from my perspective. In the UK this is entirely legitimate (importing for personal use) hence we don’t face the same problems as the USA.
I looked at ordering from there a month or so ago after things shut down from India - but at that point they just had a shipping cost of “$1,000,000” when you tried to order; so instead of shutting down the site completely it seemed the owner just changed that one variable to make it clear that things were not being shipped out.
4 Likes
Ok I’ve just received an answer today, that my order is being processed.
So we’ll see.
1 Like
Is anyone still having success with Maulik? I was just negotiating my latest order, and he explained that he did not have a UK account any more and was not accepting Wise as a payment any more. Only credit card which charges an extra 10%. I thought this was a bit odd, so I wanted to check here first.
Anyone had contact with Jagdish recently? How are the orders from India processing, are generics excluded from tariffs?
A friend ordered in Sept and recieved the order earlier this week. The order got out just before tariffs, but they were worried about it. It cleared like in the past without problems.
2 Likes
I’ve received everything as ordered
3 Likes
I was told on another forum that only 25% of packs are successfully delivered. I know some domestic resellers closed shop because of seizures, yet I question the 25% claim. Yet, I am hesitant.