I just read this thread in its entirety. Some good musings, the tangent on investment strategy notwithstanding.
Personally, I have enjoyed keeping up on Bryan’s experiments and protocols. I am on a Rapamycin break as I heal from hip resurfacing in March. So trying other longevity hacks is all I have and some of Bryan’s are accessible and fairly low risk.
I have done super veggie every day for 3 months and I really like it and how it has effected my GI/micro biome. Hard to argue with 70lbs of great veggies a mo. I do some of his supplements too but frankly was already doing them before he posted blueprint. They aren’t that earth shattering. I am 4 times into his workout. It is quite good. A lot of it is taken from the knees over toes guys, but having strong knees is important as we age. I recommend it if you haven’t tried it. Post hip surgery I am not 100% in shape enough to do all the exercises fully but they aren’t hard to modify. I also have done his mouth/teeth routine. A 1-minute addition to my dental routine is worth it to me and I like the effects on my breath and how my mouth feels and teeth and gums look. Lastly, I am curious about red light so I may try that. I know many on this site have in varying ways.
When I see all the haters it makes me think of the man in the arena quote.
Spoke to Dr. GREEN, my Rapamycin doc since 2018, and he recommended metformin as a better more sustainable way to get the acarbose (sugar control) affect without some of the stomach side effects of Acarbose.
Dr. Green indicated the mechanisms of acarbose and metformin are both attempting to manipulate IR and reduce the damage of higher free circulating blood sugar. His preference based on side effects and safety profiles was metformin.
“I think the acarbose study shows the benefit of glucose control.
So shows why metformin is good, increased insulin sensitivity
Acarbose decreases digestion of carbs.
Not convinced of benefit in humans.”
Acarbose is poorly absorbed into the bloodstream, and has a low systemic availability of less than 2% . As a result, the risk of any toxic reaction is very low and, to date, no interactions have been reported between acarbose and β-blockers, sulphonylureas, angiotensin-converting enzyme (ACE) inhibitors or warfarin therapy .