Every biohacker has their own risk tolerance and stack inclusion criteria. This may be surprising to some, but I am pretty conservative wrt. my stack, and selegiline is outside my comfort zone. I regard it as a research molecule. The studies out there are quite unsatisfying and all over the place - nothing there inspires my confidence. Dosing protocols are a huge unknown. DDI potential is high - I prefer to protect the rest of my stack which I have a decent degree of confidence in, and do not see the sense of introducing an unpredictable stranger to our stable little family.
General remark: there are literally thousands of molecules about which there are claims that they are beneficial for something or other. But if I feel that for example my systemic (dry) inflammation is already quite low (hsCRP, IL-6, GlycA, WBC, netrophils etc.), why should I care that Latest Wonder Drug supposedly is “good for dry inflammation”? There are a thousand other “good for inflammation” supps out there - I feel no need to add them to my stack. Same for “neuroprotection”, “endothelium”, “x, y, z”. If my biomarkers are where I want them (example: inflammatory markers) I don’t need more. In the film industry there is an expression describing excessive effects: “a hat on a hat”. I already have a hat, I don’t need to put another hat on top of my hat. This in general is a huge problem in the approach of many biohackers: a shiny new - or old - supp/drug has its 15 minutes of fame and everyone jumps on the bandwagon regardless of whether they need it or not, just because “it’s beneficial for x”… fishoil anyone? “Oh, it’s neuroprotective!”… please🙄.
Why do I need - or want - selegiline? It must show that it does something that no other drug/supp in my stack does, OR does it better than a drug in my stack, and fits within my specific medical situation. And the inclusion bar is VERY high - even ITP results don’t assure inclusion. Metformin + rapamycin give good longevity results in rodents, but I STILL do not take metformin, because it does not fit with the rest of my regimen and personal medical situation.
Of course, selegiline has a PD indication. OK. But, call it prejudice, or excessive caution, but anything that touches dopamine in PD I am super careful and paranoid about (for example levodopa). Furthermore, I want to see long term effects, and lifespan data is not encouraging for selegiline in PD. I have an open mind about deprenyl and PD, but I am pretty cautious about it.
Bottom line: for me selegiline is a PASS at this time.
Sorry for the length, and YMMV - of course others may have a different experience or evaluation, no judgement from me, just giving my one man opinion (and only because I was asked).
