Yes, a typo (or brain faht) 
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Yes, Renue by Science is a trusted brand. That’s should be fine.
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I have been taking Ca AKG for 5 months. Thats the only change I made to my AM stack. Initially no change but now I have noticed overall improved exercise performance past 2 months e.g., I regularly do threshold training and my recovery score and HRV has improved
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I can say that at 49, I am probably in better shape than I was at 30 (albeit with a few extra lbs.) based on my performance hiking three sections of the Great Wall. I had the endurance to keep up with the whole family while carrying a 30 lb backpack of drinks and snacks. And there was never really a time when I felt too tired. It’s great to be able to keep up the hike with my sons and wife.
I felt great and vital after our trip. Thanks to all of the meds, supplements and advice that I’ve obtained from this site!
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I could be wrong I would guess it’s something else since I would have expected benefits before two months of being on it.
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What you say is possible. Unless it is either rapamycin or mindset/ belief effect(nocebo)…
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Speaking of Brian Kennedy and AKG. He purports, consumes and sits on board of “Rejuvant”. It is supposed to be more bioavailable than generic CaAKG.
Has anyone in here tried Rejuvant? Its nearly $2 a pill!
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I’ve tried REjuvant for several months. Didn’t notice any benefit.
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I think AKG has some effects, but not really big ones.
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I tried Rejuvant for a few months and stopped bc didn’t see any changes.
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I’ve been taking LongJuvity for a couple of months because it claims to be time-release and given the half-life, this is essential, I think. Has anyone compared this formulation with the much more expensive Rejuvant?
The consensus of the AI gang is that Rejuvant, Renue by Science (US), and Purovitalis (EU) are the Tier 1 providers, noting that Rejuvant’s TR technology is the only one that is backed by eight years of research. Also noted is that assimilation with legitimate liposomal formulations is superior to Rejuvant’s technology which is likely a benefit but not necessarily so because there could be an as yet undiscovered gating issue in the intestinal assimilation. A strong suggestion was to stick with Tier 1 producers for the time being.
Many people will not and should not “feel” any different in the short term when supplementing with CaAKG, although some will get an energy boost. Eight week results are most likely to be decreased exercise recovery time and endurance. Six months effects will be reflected in telomeres, inflammation, and frailty metrics such as gait speed and grip strength. Based on what I have learned to date, I’m going to try a 50/50 mix of Rejuvant and Renue by Science; i.e., one capsule each per day.
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Metabolic and Immunomodulatory Effects of α-Ketoglutarate in Burn Injuries: A Systematic Review
https://academic.oup.com/jbcr/advance-article-abstract/doi/10.1093/jbcr/irag002/8417200
Authors are from the University of Heidelberg, part of the medical faculty.
Fifteen studies published between 1984 and 2024 met inclusion criteria, including clinical, animal, and mechanistic work, most conducted in France. Across studies, OKG supplementation replenished glutamine and arginine pools, improved nitrogen balance, preserved muscle mass, and promoted wound healing through enhanced collagen synthesis and immune modulation. Clinical data confirmed improved nitrogen retention, reduced muscle breakdown, and faster wound closure. Preclinical studies further showed that α-KG preconditioning enhances stem cell–driven regeneration and vascularization. Additional effects, such as improved glucose tolerance and hepatic enzyme preservation, suggest some benefits occur independently of glutamine pathways.
This review highlights α-KG and OKG as promising adjuncts to enhance metabolic recovery, wound repair, and immune competence after burns. Evidence supports improved nitrogen balance and healing, but findings remain limited by heterogeneity and small cohorts, warranting renewed and well-powered studies.
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I take it and I do think it helps me feel better - I did some functional genomics and NAD blood tests with Bob Miller at Tree of life and from those results it came up as beneficial for me. It theoretically replenishes α-ketoglutarate that gets drained during ammonia buffering, keeping my TCA cycle/mitochondria running so I can clear nitrogen better and “use” NADH for energy instead of feeling backed up and inflamed. I have abnormally high levels of NAD so NAD/NADH supplements make me feel awful.
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Ericross2, I believe you are correct. From my reading the ITP results do not show lifespan extension. Here is a link to ITP Testing for anyone who is interested. Items are listed alphabetically on this report. When you find a-Ketoglutarate (AKG) click on View Survival Analysis to see results. The graphs don’t show a-Ketoglutarate (AKG) being better than placebo, but maybe slightly worse.
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That was the most surprising result from the ITP in my opinion. It looked so promising until that. I still take it but I have less confidence in it that I used to.
I take it every morning as part of our MAX-5 Super Mix
The Max 5 daily dose includes;
| Spermidine 98% | 25.0 mg |
|---|---|
| Ergothionene 99% | 20.0 mg |
| Urolithin A 97% | 500.0 mg |
| Ca-AKG 100% | 800.0 mg |
| NMN 99.5% | 800.0 mg |
Also take 300mg of NR
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@Steve_Combi thanks for sharing!
I’m assuming you take everything in powder form, right? If so, I’m just here to ask how bad does that mix taste (I’m a baby)
And more so, do you believe the $$Rejuvant slow release CA AKG is just marketing, or is there something to it? I don’t take theirs due to the cost, but I keep wondering about this.
I’m seriously considering ditching my Blueprint multi and taking things individually to get ideal dosing… but I keep hesitating because doing so would add many more pills.
At the risk of going off topic, I see your formulation has a strong NAD+ precursor element. Could you please share what’s behind that thinking? This recent paper doesn’t really provide me with a convincing case with phrases like: A clear trend emerges from this Review: a consistent age-related
decline in NAD+ levels is observed in muscle but not in whole blood.However, NAD+ boosting does not seem to change muscle NAD+ levels while easily increasing whole-blood NAD+ concentration.
Not tasty at all LoL!
I consume things for 1 of 2 reasons and in some cases for both,
- pleasure
- nutritional value
I can do the second one without the pleasure part but I do disguise the real nasty stuff with a shake
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Using TruDiagnostice epigenetic testing, 5 tests over 4 years, my telos increased in length with every test. The only thing I’m aware of taking that would have done that is NMN and NR.
My main interest in having NAD precursors present in my formula is multi-fold and speculative based on the mechanistic of those compounds. It’s still early days with respect to studies and as these are commonly available and now at commodity level pricing, I’d guess there will be fewer studies going forward. But who knows.
NMN and NR what are the mechanistic and benefits o (1).pdf (754.5 KB)
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