This is not the paper I read but the conclusions are the same. Thanks for the informative link
How is this going for you? Mine arrived today.
It’s going well. However, I can’t really feel or see any difference. No good or bad side effects that I can notice.
1 Like
Thank you. I will trial it since I have just bought it- no side effects works well for me. I did more reading on it and I think this wont do any harm at least.
2 Likes
He seems overly pessimistic about combining longevity interventions. I’m personally more optimistic that most things work better in combination. He made vague comments about noticing things in rats about it but never got specific.
1 Like
I may be misremembering, but I had thought the ITP found the combinations rarely work. Perhaps we are all being optimistic?
Here is a link of a discussion of this in this forum: Efficient Combination of Longevity Strategies - #2 by Ray1
Rapamycin and Acarbose together certainly worked better than when each was used alone
4 Likes
Where do you procure Potassium AKG from?
Bulk Supppements sell arginine AKG. I think it costs mich less tha. Rejuvant etc.
Since most of the data is on CaAKG, is it safe to extrpolate therapeutic equivalence to arginine or Potassium AKG?
Been taking for 2 months. Haven’t noticed any difference in performance. I felt pretty good prior and after taking it. I do Zone 2 cardio 3-4 days and zone 5 interval training 2 days a week.
Resting heart is 50-53.
HRV 70s
1 Like
Sorry, that was an error on my part. I was taking Nutricost Arginine AKG and Nutricost Potassium BHB. I noticed no subjective benefits from them except the Nutricost Arginine AKG, which lowered my blood pressure a little bit.
I once spoke to a researcher who specializes in muscle growth. He maintained that oral Arginine is not well absorbed.
2 Likes
I think that the CA-AKG formulation is designed to counteract the acidity of AKG, at least as recounted by Bryian Kennedy (and hoping my memory serves me well enough). It would seem that (as recounted also by Andrea Meier of Singapore University) the main longevity benefits due to Ca-AKG is actually healthspan benefits related to counteracting frailty, and this would agree with the slight anabolic effect of AAKG observed by bodybuilders, an effect which probably targets musculoskeletal tissue, including tendons and connective tissue.
AAKG is also part of a formulation of supplements prescribed by orthopedists here for tendon issues.
I did not notice positive effects from the assumption of AAKG, but to tell the truth, I never observed any direct impact from any other supplements, barred berberine, which was anorexizant at the dose of 1000 mg/d.
1 Like
I just randomly decided to start taking AKG again, but the A-AKG version which is cheaper. I got excited about it from the 7 years younger biological age news, but stopped after the ITP result. Brian Kennedy still seems to like it, for what it’s worth.
AKG appears to decline as we age, so I like the idea of that not happening. It’s cheap (except if you take the C-AKG version). I hope this continues to be researched.
5 Likes
I have a question!!!
I don’t know anything about akg other than it’s thrown around as a potentially good thing.
A few months ago I started taking calcium for my low levels of osteoporosis.
Google says CA-AKG can help too.
If one should be taking calcium, is there any reason to take regular ol’ calcium over ca-akg?
If not, is there any downside of switching to ca-akg for the potential benefit of akg
1 Like
I’d defer to the physicians for specific advice, but while Ca-AKG does appear to have some benefit in reducing osteoporosis, I’d point out that as a calcium salt attched to AKG its probably not enough calcium in a normal supplement to satisfy your daily needs for calcium. I think I started this thread long ago because of a clinical trial that showed some longevity benefits, but it is now being touted for a variety of benefits, including preventing arthritis. One caution on your calcium intake: there have been some studies that have raised concerns about taking too much calcium in one dose because it could potentially lead to calcium deposits in arteries, causing heart disease. So it may be best to take 500 mg or less at a time.
3 Likes
It makes more sense to take AAKG anyways. There’s evidence that high dietary calcium (700-1,000mg/day) or calcium supplementation (1,000mg/day) increases CVD and CHD risk in certain subgroups.
The mice in the ITP are taking the human equivalent dose of 3.75g supplemental calcium. I’d like to see it repeated with AAKG.
1 Like
Yea I would much rather avoid taking extra calcium, however, the version of AKG tested that reversed biological aging according to those (questionable) aging clocks was bound to calcium, so that’s why I used to use that version. Nutricost A-AKG is really cheap though. $20 usd for 120 days worth of it if you use 1g per day. I figure it’s low risk and either no reward or high reward.
3 Likes
Calcium in Ca-AKG is not the same calcium that you need for bones. I discussed it with my doctor. I use New Chapter plant calcium Bone Strength. And for healthy aging I use Double Wood AKG, which is better than AAKG.
1 Like
That’s very helpful info, thank you!
Is there a reason you chose AKG vs CA-AKG?
New chapter looks like a great product… a more affordable version of AlgaeCal
I looked up strontium when I first came across their website and was scared off by reading a potential risk for those with heart disease. I didn’t do much reading about it. If you are taking it, I’m going to assume that might not really be a thing, so I’ll read up on it.
And thx @Uppereast69 I’ll look more into ca-akg, too. I have a lot of plaque so I am nervous about taking calcium, but I take a ton of k2, so hopefully that makes it safe.
I do take 250mg of either algae calcium or, usually dicalcium malate per day.
There is a little calcium in my vegan collagen drink. I wind up taking 100mg of calcium carbonate twice a day.
So my grand total of calcium supplementation per day is 450mg.
I’m glad you gave me the heads up about not taking too much at one sitting, so now I’ll be more cognizant on the timing of when I’m taking things. Do you think this includes food too, like kale, or just non food supplements?
Brian Kennedy on AKG.
It has a significant effect on biologically older (unhealthy) individuals.
Also starting a Rapamycin trial soon.
4 Likes
@DeStrider That was great, thank you!
My main question is how supplementing with AKG might impact the amount of regular calcium I should be taking for bone health, as I want to avoid over consuming calcium and potentially putting my heart health at risk.
EDIT: OH, I now see Rejuvant breaks down how much calcium it contains, so that answers my question, at least for that brand. I had picked up the Do Not Age a while ago, but they couldn’t answer me on how much calcium it contained, so I was flying blind.
He mentioned Rejuvant, which has one for men and women, but it’s twice as expensive… thoughts? Obviously paying half is appealing 
On his good point of the unknown interaction amongst the various supplements we might be taking, do we have a thread that contains which molecules we should not be combining?
2 Likes