I have been plagued by severe abdominal discomfort on and off for 3 years now. It was in the vicinity of my gall bladder so I had the usual ultrasound exams done, etc.
Only late last year did it dawn on me that this abdominal misery coincided with me taking NAC. When I stopped taking it; the condition vanished. When I resumed NAC; it returned.
Anyone else experience this?
I have reduced my dose of glycine and NAC from 100 mg/kg body weight to 65 mg/kg body weight because I felt mentally off at the higher dose. I suspect this might have been due to the glycine. I also take the first daytime dose together with collagen. I calculate the total amount of glycine from the collagen I take and then add some extra pure glycine, to reach my target dose. In the evening I use a mix of only NAC+glycine. this works well for me.
Abdominal discomfort is a known sideffect from NAC. Sorry to hear that it happened to you.
I have acid reflux and NAC makes it much worse.
I also like that they had young adults with normal glutathione status in their 20s take GlyNAC for two weeks and it showed no benefits in them, meaning some people donāt need it but it could be borderline miraculous in people who do
Same here. NAC causes stomach pain for me so I simply donāt take it.
Hereās a primer on the background information about GSH, NAC, Glycine and Taurine.
what kind of side effects are u experiencing?
are they the same as mine? due to the glycine boosting serotonin? haha.
the extreme self control, low libido, etc.
right now i am on 2g glycine daily and i can tell you i still have zero libido, its amazing and yet a bit scary haha. i sometimes take 1 extra gram with a bit of melatonin before sleep.
actually its not that i have zero libido but more like i can totally control the urge to have sex, to buy stuff, to say something, to do something.
when i was on higher glycine, such as 6g, i felt a lot more humourous, like i would crack more jokes and joke with ppl. i seem to be able to āread peopleā a lot more easily as well, like sense what they are thinking etc. on 2g, i donāt feel it so much.
my monthly spending has dropped by 70%, my monthly sex has dropped by 90%, etc lol. i should have taken this thing decades ago, i would be able to save so much money and FIRED by now haha
frankly i there is still effects on them.
because glycine has effects by itself on the body, like it can alleviate schizophrenia, OCD, depression, anxiety, a whole host of mental illnesses, i think likely due to what i discussed above, the serotonin effect. There was also a recent science article where they discovered gpr158, glycine can bind to it and slow down neural activity.
hence the baylors scientists keep harping on it being the āpower of 3ā and not just via gluthathione alone.
This study by Drs. Greenberg and Javitt aimed to explore whether adding glycine (an amino acid that helps in glutamate receptor N -methyl-D-aspartate (NMDA) transmission) vs. placebo would help enhance medication treatments. 24 participants with OCD were randomized to adding either 60 grams of glycine a day to their medication (after drop-out, n =3) or adding a placebo (after drop-out, n =5). Over the course of at least 12 weeks, participants in the glycine group experienced statistically significant reduction in OCD symptoms compared to placebo. The high rates of drop-out in both groups were due to side effects, not adhering to the treatment plan, and a variety of other reasons.
JUPITER, Fla.ā A common amino acid, glycine, can deliver a strong signal to the brain, likely helping alleviate major depression, anxiety and other mood disorders in some people, scientists at The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology report online in the journal Science today.
Glycine treatment was well tolerated and induced increased glycine (P =.001) and serine (P =.001) serum levels. Glycine administration resulted in (l) a significant (P <.001) 30%Ā±16% reduction in negative symptoms, as measured by the PANSS; and (2) a significant (P <.001) 30%Ā±18% improvement in the BPRS total scores. The improvement in negative symptoms was unrelated to alterations in extrapyramidal effects or symptoms of depression. Low pretreatment glycine serum levels significantly predicted (r =0.80) clinical response.
I experienced drowsiness and brain fog when I reached 7 grams per day. Since glycine can influence neurotransmitters in the brain and is sometimes used to support sleep, it makes sense that some people may feel more tired or a bit slow or mentally āoffā at higher doses. Now that Iām taking 4.55 grams per day, split into a morning and an evening dose, I feel good.
Until we have accurate biological age clocks these types of trials are not realistic in humans.
I get a bit of that as well (less clear thinking).
I take 1g glycine and melatonin before bed wow really sleep like a log haha
Its good for sleepingš
https://pmc.ncbi.nlm.nih.gov/articles/PMC4397399/#bib8
Despite evidence from human trials that glycine intake before bedtime improves sleep quality both subjectively and objectively (Bannai et al, 2012; Inagawa et al, 2006; Yamadera et al, 2007), details of its mechanism remain poorly understood. We have revealed the site of action of glycine that promotes sleep and a novel mechanism for regulating sleep and temperature. In acute sleep disturbance during the resting period, glycine administration promoted sleep and shortened NREM sleep latency associated with a decrease in Tb (Figure 1). The time course of the decrease in Tb correlated well with the timing of sleep onset and the rise in CBF (Figure 1g and Figure 2aād). Peripheral vasodilatation was mediated by activation of NMDA but not glycine receptors in the brain (Figure 2e and f). This finding is consistent with the pharmacokinetics and distribution in the brain following glycine administration (Kawai et al, 2011). Glycine administration increases L-serine (Kawai et al, 2011) and L-serine can be converted to D-serine by serine racemase. To exclude the possibility that the effects observed may partially be mediated by D-serine, we investigated D-serine concentrations in CSF 30 min, 2 and 8 h after the oral administration of 2 g/kg glycine. We found no significant change in the CSF D-serine level (Figure 5). This result indicates that glycine itself acts on NMDA receptors.
NAC in water is highly acidic. Like ph of 2, same as ur gastric juice.
So that could explain why some ppl have stomach pains etc.
Eating it with meals or drinking lots of water could help.
here is a good primer on glynac by a guy called henry bee. itās the most easy to read summary primer i have read so far.
The new version of Claude AI which I now think is the best AI app after the update just convinced me to stop taking NAC since I am 40 with optimal labs and exercise a lot. Honestly itās probably right so I will stop. But itās amazing for people who truly need it.
I think 40 is a gd age to take glynac.
30 is even better.
If it slows down our aging by 30% for example and average lifespan in ur country is 80yo for eg
U originally have 40y more but glynac extends that to 55.
So u end up living till hpepfully 95yo instead of 80yo.
Starting at 60 70 is helpful but a bit too late imo
A lot of the dna damage and various physical biolgical damages in cells mitochondria etc has already been permanently done
U can help to prevent more or even erase a bit but most of the damage has been incurred
I think that 40 is a good age to start GlyNAC considering it starts decreasing at 30.
I think oxidative stress is more complex than just replace glutathione and you basically fix it. In all likelihood glutathione would help but I doubt it is the only thing that matters.
According to this, it declines rapidly from age 45. Dr. Stanfield often quotes this study
I would imagine it stays in tact longer in health exercisers
Does replacing glutathione levels when they decrease lead to functional improvements?
There is pretty solid evidence in rats and humans it does great benefits to health and even lifespan
For me i am just hoping to see more replication of studies the science looks solid