[Note: Avi got some of the details wrong here, Rapamycin has improved lifespan by up to 26% and over 29 labs have confirmed lifespan improvements, etc. but the generalities and the cost information is correct]
6 drugs under $1/day being tested to slow aging (plus 1 expensive outlier with the biggest result):
Rapamycin ($0.30/day) - Extended lifespan 12-15% in mice. 7 labs confirmed. Human trials ongoing for immune aging.
Acarbose ($0.30/day) - Extended male mouse lifespan 22%. Diabetes drug since 1995. Slows glucose spikes.
Metformin ($0.10/day) - TAME trial (3,000 people, 6 years) testing whether it delays age-related disease. Most prescribed diabetes drug in history.
Glycine ($0.05/day) - An amino acid. Extended mouse lifespan 6%. Costs less than coffee. Available without prescription.
Captopril ($0.15/day) - Blood pressure drug. Extended mouse lifespan in ITP. Mechanism: reduces angiotensin damage.
Henagliflozin ($0.30/day) - SGLT2 inhibitor. First drug to lengthen telomeres in a randomized trial (90.5% vs 65.6%).
Trametinib (expensive, ~$200+/day brand, no generic yet) - Combined with rapamycin: 30% lifespan extension. FDA-approved cancer drug. Included because it produced the biggest aging result ever seen in combination.
None are approved for aging. All are in trials or have strong animal data. Total daily cost of the first six: $1.20.
Source: https://x.com/agingroy/status/2052788674715075028?s=20