Whatever psilocybin does, this is much shorter and more powerful
Nick cammarata said it’s the perfect treatment if you just figure out how to reduce the nightmare probability
In a large percent of ppl, it seems easiest way to one shot wellness
Plus LEGAL IN CANADA
https://x.com/0xQuasark/status/2013701597268783385?s=20
Full Open Access Paper: Complex slow waves in the human brain under 5-MeO-DMT
The “God Molecule” Paradox: 5-MeO-DMT Freezes Brain Waves to Deconstruct Reality
Institution: University College London (UCL), UK Journal: Cell Reports (August 2025)
Overview: For the first time, researchers have captured the neural signature of the “void”—the total annihilation of self and space reported by users of 5-MeO-DMT. Unlike classical psychedelics (LSD, psilocybin), which typically increase neural entropy (chaos) and scramble communication, this study reveals a startling paradox: 5-MeO-DMT pushes the brain into a state of hyper-stability.
Using high-density EEG on 29 subjects inhaling 12mg of synthetic 5-MeO-DMT, the team discovered that the drug effectively “breaks” the traveling waves of electrical activity that normally sweep across the cortex to coordinate perception. Instead of a fluid river of information, the brain’s activity fractures into viscous, non-recurring eddies that cannot travel forward or backward. The “energy landscape” of the brain deepens, trapping neural activity in a low-dimensional “stiff” state.
This suggests that the subjective experience of “oneness” or “nothingness” isn’t an explosion of connectivity, but a collapse of the spatiotemporal scaffolding that constructs our reality.
The researchers discovered that 5-MeO-DMT generates high-amplitude “slow waves” (usually a sign of deep sleep or coma) while the subject remains fully awake. However, unlike the synchronized slow waves of sleep, these waves are “viscous,” incoherent, and unable to propagate globally. This effectively fragments the brain’s communication network, preventing the integration of information required to sustain the “self.”
Source:
While the paper focuses on EEG dynamics, the findings unlock significant implications for longevity, specifically regarding allostatic load reduction and neural plasticity.
Warning: 5-MeO-DMT is extremely potent. The following is based on clinical parameters, not medical advice.
1. Is “deconstructed consciousness” just a fancy word for blacking out? No. The study proves you are physiologicallyawake (muscles active, eyes can open) and phenomenologically conscious (aware of “being”), but the content of consciousness (vision, self, time) is deleted. It’s like formatting a hard drive vs. turning off the computer.
2. Does this actually extend lifespan? No direct evidence exists. However, if it reduces chronic cortisol and treats depression (which shortens telomeres), it acts as a geroprotector proxy. The massive release of acute stress hormones during the trip is a hormetic stressor—beneficial only if recovery is adequate.
3. How does this compare to Psilocybin for longevity? Psilocybin induces hyper-connectivity (“entropic brain”). 5-MeO-DMT induces disconnection (“void”). 5-MeO is better for “breaking” rigid patterns (addiction, OCD) rapidly; Psilocybin is better for “rewiring” emotional insights over hours.
4. Can I stack this with Rapamycin? Likely yes. Rapamycin (mTOR inhibitor) has no known interaction with acute serotonergic agonists. However, avoid stacking with Lithium (seizure risk) or SSRIs/MAOIs (Serotonin Syndrome).
5. What is the “Viscosity” finding telling us about brain aging? Brain aging is often characterized by “stiffness” or loss of dynamic flexibility. Paradoxically, 5-MeO increases viscosity acutely to force the brain into a simple state, potentially allowing it to “reboot” into a more flexible state post-trip. This is the “shake the snowglobe” effect.
6. Is the “Toad” venom better than synthetic? Scientifically, no. Toad venom (Incilius alvarius) contains 5-MeO-DMT plus bufotenin and other toxins (cardiotoxic). Synthetic 12mg is cleaner, more precise, and avoids animal cruelty issues. The study used synthetic.
7. Why 12mg? 12mg is a high dose designed to guarantee “breakthrough.” Lower doses (3-6mg) can induce anxiety without the release of ego dissolution, often resulting in a “panic” state rather than a “void” state.
8. Is there a “Hangover”? Rarely. Most users report an “afterglow” lasting days to weeks. However, “reactivations” (spontaneous brief flashbacks of the sensation) can occur in the week following high doses.
9. What if I have high blood pressure? Do not use. The acute spike in BP is significant. If you are managing hypertension, this is a contraindication until stable.
10. What is the single most actionable takeaway? If you are a biohacker looking for a “neural defrag” to combat executive burnout or rigid thinking, 5-MeO-DMT offers the highest time-efficiency. However, it requires a sitter and cardiac safety, unlike sub-perceptual microdosing. Treatment should be viewed as a high-intensity interval training (HIIT) session for the brain.
The psychedelic 5-MeO-DMT seemed to induce similar patterns of brain activity in a lama - a revered spiritual teacher in Tibetan Buddhism - as meditation, advancing our understanding of the drug’s neurological effects
A master meditator has spent 15 years learning to quiet his sense of self – and brain scans suggest he achieved a similarly altered state with a powerful psychedelic.
“There seems to be, with that low dose [of the psychedelic], a significant overlap in terms of brain activity with what’s happening in non-dual meditation state [a style of practice that makes no distinction between the self and the rest of the world],” says Christopher Timmermann at University College London.
The study was also made up of a single, experienced meditator, so the results may not apply more broadly, particularly as brain-activity related studies can be unreliable. What’s more, blinding participants is notoriously difficult in psychedelic research, because the side effects of hallucinogenic drugs usually alert people to when they have taken them, as opposed to a placebo, although the lama didn’t report such effects.
Read the full story: Psychedelic causes similar brain state to meditation (New Scientist)
Full academic paper (pre-print) that is the basis for the previous news article:
I would caution anyone unfamiliar with 5-meo-dmt, and looking at this as a new “biohacking” or longevity tool to really research the pros and cons of trying this. Also read some trip reports on erowid or watch some videos of people taking it. This is probably the pinnacle of an intense psychoactive experience. Despite having such a short duration, many people who are very experienced with taking things like LSD, mushrooms, mescaline, and even regular DMT are terrified of using 5-meo-dmt. While it can potentially offer life changing positive effects, the opposite is also true and not uncommon, leaving some with lifelong mental health issues and changes in personality. I would avoid or proceed with extreme caution and only if you feel you are in a very good place in life and healthy mental state. There are other safer alternatives that can offer the same benefits.
Some 30 years ago, long before it became a controlled substance in the USA in 2011, a friend who is definitely not me actually tried 5-MeO. It was just a pinch of powder smoked, no idea the dose. It was described as like blasting off in a rocket – all of that feeling of overwhelming “intensity” of a strong psychedelic trip, but multiplied by a thousand, and at the same time absolutely zero visual effects and zero euphoria, just hanging on for dear life. The whole thing only lasted maybe 5 min (?) but even that was too much. Not an experience that was ever desired to be repeated. One can only assume/hope that the presumably lower doses used in the research setting as a nasal spray are better tolerated.
Good warnings from the above posters. A little digging reveals lots of potential negative side effects, probably not very “pro-longevity” from the data I’ve seen so far:
5-Methoxy-N,N-dimethyltryptamine (5-MeO-DMT) is a potent, fast-acting tryptamine. It is chemically and pharmacologically distinct from N,N-DMT (“DMT”). While N,N-DMT primarily activates the 5-HT2A receptor, 5-MeO-DMT has an exceptionally high binding affinity for the 5-HT1A receptor. This difference drives its unique safety profile, which includes a higher risk of respiratory depression and serotonin toxicity compared to other classic psychedelics.
The immediate physical load on the body is significant and occurs within seconds of inhalation or injection.
The experience is often described as a “whiteout” or total void, rather than the visual hallucinations common with other tryptamines.
5-MeO-DMT has a narrower therapeutic index than psilocybin or LSD regarding interactions.
MAOIs (Monoamine Oxidase Inhibitors): Combining 5-MeO-DMT with MAOIs is potentially lethal. This includes prescription MAOIs and harmala alkaloids found in Ayahuasca (Banisteriopsis caapi) or Syrian Rue.
Critical Distinction: N,N-DMT is orally active only when combined with an MAOI (Ayahuasca). 5-MeO-DMT combined with an MAOI causes serotonin syndrome, hypertensive crisis, and death.
SSRIs and SNRIs: Because 5-MeO-DMT inhibits the reuptake of serotonin (interaction with SERT), combining it with antidepressants carries a risk of serotonin syndrome.
Lithium: Combining Lithium (often used for Bipolar Disorder) with tryptamines is known to lower the seizure threshold drastically. This combination can result in fugue states, seizures, and heart failure.
Alcohol: Alcohol acts as a respiratory depressant. Combining it with 5-MeO-DMT increases the risk of vomiting and respiratory failure.
There is a clinical difference between synthetic 5-MeO-DMT and the dried venom of the Colorado River Toad.
The 5-MeO-DMT entries in TiHKAL succinctly captures the gravity of the experience it produces:
(with perhaps 15 mg, smoked) “I took a hit from the pipe with five-methoxy in it, and after the 8 to 10 seconds it took to carry the chemical to my brain I remember starting to fall over from my sitting position. My normal physical perceptions dissolved away from my awareness. My ears started to ring and I started to float off. I was acutely aware of a certain resonation of my aural perception, an electrical buzzing that fluctuated in synch with my visual perception. What I saw can only be described as a fantastically subtle multicolored phosphene, completely filling every area visually available. I say it in this way because I was simultaneously losing contact with my body, I could not tell if my eyes were open or shut, although I initially had the feeling that they were darting back and forth, from side to side. These feelings and sensations built up in intensity very quickly, a matter of seconds: I can remember this feeling of building intensity up to a point, and then I was not there in my body or in time. In the 10 to 15 minutes that my body was under the influence of the drug my mind was completely referenceless, there was no way for my consciousness to limit or gauge the stimuli my being was barraged with. I remember switching to a perception where the endless and intricate phosphene was love and the energy of light. I called upon those forces within my being to realign and submit, to let go of all the cogent fears and just exist … and that innate decision saved me a lot of psychic damage. What is most outstanding about the way it feels is an inability to judge in any way, by any method of the mind … it is unconquerable, as deep and profound as a totally unconditional love that is life. What a trip, huh?”
(with 15 mg, smoked) “At about 60 seconds after I smoked this free base, I beheld every thought that was going on everywhere in the universe and all possible realities while I was wracked out with this horrible ruthless love. It scared the hell out of me. When I could see again (15 minutes later) it was almost as if there was an echo of a thought in my head saying that I was given an extremely rare look at the true consciousness of it all. I’ve never been hit this hard since then. A definite ++++.”
