Whatever psilocybin does, this is much shorter and more powerful
Nick cammarata said it’s the perfect treatment if you just figure out how to reduce the nightmare probability
In a large percent of ppl, it seems easiest way to one shot wellness
Plus LEGAL IN CANADA
https://x.com/0xQuasark/status/2013701597268783385?s=20
Full Open Access Paper: Complex slow waves in the human brain under 5-MeO-DMT
The “God Molecule” Paradox: 5-MeO-DMT Freezes Brain Waves to Deconstruct Reality
Institution: University College London (UCL), UK Journal: Cell Reports (August 2025)
Overview: For the first time, researchers have captured the neural signature of the “void”—the total annihilation of self and space reported by users of 5-MeO-DMT. Unlike classical psychedelics (LSD, psilocybin), which typically increase neural entropy (chaos) and scramble communication, this study reveals a startling paradox: 5-MeO-DMT pushes the brain into a state of hyper-stability.
Using high-density EEG on 29 subjects inhaling 12mg of synthetic 5-MeO-DMT, the team discovered that the drug effectively “breaks” the traveling waves of electrical activity that normally sweep across the cortex to coordinate perception. Instead of a fluid river of information, the brain’s activity fractures into viscous, non-recurring eddies that cannot travel forward or backward. The “energy landscape” of the brain deepens, trapping neural activity in a low-dimensional “stiff” state.
This suggests that the subjective experience of “oneness” or “nothingness” isn’t an explosion of connectivity, but a collapse of the spatiotemporal scaffolding that constructs our reality.
The researchers discovered that 5-MeO-DMT generates high-amplitude “slow waves” (usually a sign of deep sleep or coma) while the subject remains fully awake. However, unlike the synchronized slow waves of sleep, these waves are “viscous,” incoherent, and unable to propagate globally. This effectively fragments the brain’s communication network, preventing the integration of information required to sustain the “self.”
Source:
While the paper focuses on EEG dynamics, the findings unlock significant implications for longevity, specifically regarding allostatic load reduction and neural plasticity.
Warning: 5-MeO-DMT is extremely potent. The following is based on clinical parameters, not medical advice.
1. Is “deconstructed consciousness” just a fancy word for blacking out? No. The study proves you are physiologicallyawake (muscles active, eyes can open) and phenomenologically conscious (aware of “being”), but the content of consciousness (vision, self, time) is deleted. It’s like formatting a hard drive vs. turning off the computer.
2. Does this actually extend lifespan? No direct evidence exists. However, if it reduces chronic cortisol and treats depression (which shortens telomeres), it acts as a geroprotector proxy. The massive release of acute stress hormones during the trip is a hormetic stressor—beneficial only if recovery is adequate.
3. How does this compare to Psilocybin for longevity? Psilocybin induces hyper-connectivity (“entropic brain”). 5-MeO-DMT induces disconnection (“void”). 5-MeO is better for “breaking” rigid patterns (addiction, OCD) rapidly; Psilocybin is better for “rewiring” emotional insights over hours.
4. Can I stack this with Rapamycin? Likely yes. Rapamycin (mTOR inhibitor) has no known interaction with acute serotonergic agonists. However, avoid stacking with Lithium (seizure risk) or SSRIs/MAOIs (Serotonin Syndrome).
5. What is the “Viscosity” finding telling us about brain aging? Brain aging is often characterized by “stiffness” or loss of dynamic flexibility. Paradoxically, 5-MeO increases viscosity acutely to force the brain into a simple state, potentially allowing it to “reboot” into a more flexible state post-trip. This is the “shake the snowglobe” effect.
6. Is the “Toad” venom better than synthetic? Scientifically, no. Toad venom (Incilius alvarius) contains 5-MeO-DMT plus bufotenin and other toxins (cardiotoxic). Synthetic 12mg is cleaner, more precise, and avoids animal cruelty issues. The study used synthetic.
7. Why 12mg? 12mg is a high dose designed to guarantee “breakthrough.” Lower doses (3-6mg) can induce anxiety without the release of ego dissolution, often resulting in a “panic” state rather than a “void” state.
8. Is there a “Hangover”? Rarely. Most users report an “afterglow” lasting days to weeks. However, “reactivations” (spontaneous brief flashbacks of the sensation) can occur in the week following high doses.
9. What if I have high blood pressure? Do not use. The acute spike in BP is significant. If you are managing hypertension, this is a contraindication until stable.
10. What is the single most actionable takeaway? If you are a biohacker looking for a “neural defrag” to combat executive burnout or rigid thinking, 5-MeO-DMT offers the highest time-efficiency. However, it requires a sitter and cardiac safety, unlike sub-perceptual microdosing. Treatment should be viewed as a high-intensity interval training (HIIT) session for the brain.
The psychedelic 5-MeO-DMT seemed to induce similar patterns of brain activity in a lama - a revered spiritual teacher in Tibetan Buddhism - as meditation, advancing our understanding of the drug’s neurological effects
A master meditator has spent 15 years learning to quiet his sense of self – and brain scans suggest he achieved a similarly altered state with a powerful psychedelic.
“There seems to be, with that low dose [of the psychedelic], a significant overlap in terms of brain activity with what’s happening in non-dual meditation state [a style of practice that makes no distinction between the self and the rest of the world],” says Christopher Timmermann at University College London.
The study was also made up of a single, experienced meditator, so the results may not apply more broadly, particularly as brain-activity related studies can be unreliable. What’s more, blinding participants is notoriously difficult in psychedelic research, because the side effects of hallucinogenic drugs usually alert people to when they have taken them, as opposed to a placebo, although the lama didn’t report such effects.
Read the full story: Psychedelic causes similar brain state to meditation (New Scientist)
Full academic paper (pre-print) that is the basis for the previous news article:
I would caution anyone unfamiliar with 5-meo-dmt, and looking at this as a new “biohacking” or longevity tool to really research the pros and cons of trying this. Also read some trip reports on erowid or watch some videos of people taking it. This is probably the pinnacle of an intense psychoactive experience. Despite having such a short duration, many people who are very experienced with taking things like LSD, mushrooms, mescaline, and even regular DMT are terrified of using 5-meo-dmt. While it can potentially offer life changing positive effects, the opposite is also true and not uncommon, leaving some with lifelong mental health issues and changes in personality. I would avoid or proceed with extreme caution and only if you feel you are in a very good place in life and healthy mental state. There are other safer alternatives that can offer the same benefits.
Some 30 years ago, long before it became a controlled substance in the USA in 2011, a friend who is definitely not me actually tried 5-MeO. It was just a pinch of powder smoked, no idea the dose. It was described as like blasting off in a rocket – all of that feeling of overwhelming “intensity” of a strong psychedelic trip, but multiplied by a thousand, and at the same time absolutely zero visual effects and zero euphoria, just hanging on for dear life. The whole thing only lasted maybe 5 min (?) but even that was too much. Not an experience that was ever desired to be repeated. One can only assume/hope that the presumably lower doses used in the research setting as a nasal spray are better tolerated.
Good warnings from the above posters. A little digging reveals lots of potential negative side effects, probably not very “pro-longevity” from the data I’ve seen so far:
5-Methoxy-N,N-dimethyltryptamine (5-MeO-DMT) is a potent, fast-acting tryptamine. It is chemically and pharmacologically distinct from N,N-DMT (“DMT”). While N,N-DMT primarily activates the 5-HT2A receptor, 5-MeO-DMT has an exceptionally high binding affinity for the 5-HT1A receptor. This difference drives its unique safety profile, which includes a higher risk of respiratory depression and serotonin toxicity compared to other classic psychedelics.
The immediate physical load on the body is significant and occurs within seconds of inhalation or injection.
The experience is often described as a “whiteout” or total void, rather than the visual hallucinations common with other tryptamines.
5-MeO-DMT has a narrower therapeutic index than psilocybin or LSD regarding interactions.
MAOIs (Monoamine Oxidase Inhibitors): Combining 5-MeO-DMT with MAOIs is potentially lethal. This includes prescription MAOIs and harmala alkaloids found in Ayahuasca (Banisteriopsis caapi) or Syrian Rue.
Critical Distinction: N,N-DMT is orally active only when combined with an MAOI (Ayahuasca). 5-MeO-DMT combined with an MAOI causes serotonin syndrome, hypertensive crisis, and death.
SSRIs and SNRIs: Because 5-MeO-DMT inhibits the reuptake of serotonin (interaction with SERT), combining it with antidepressants carries a risk of serotonin syndrome.
Lithium: Combining Lithium (often used for Bipolar Disorder) with tryptamines is known to lower the seizure threshold drastically. This combination can result in fugue states, seizures, and heart failure.
Alcohol: Alcohol acts as a respiratory depressant. Combining it with 5-MeO-DMT increases the risk of vomiting and respiratory failure.
There is a clinical difference between synthetic 5-MeO-DMT and the dried venom of the Colorado River Toad.
The 5-MeO-DMT entries in TiHKAL succinctly captures the gravity of the experience it produces:
(with perhaps 15 mg, smoked) “I took a hit from the pipe with five-methoxy in it, and after the 8 to 10 seconds it took to carry the chemical to my brain I remember starting to fall over from my sitting position. My normal physical perceptions dissolved away from my awareness. My ears started to ring and I started to float off. I was acutely aware of a certain resonation of my aural perception, an electrical buzzing that fluctuated in synch with my visual perception. What I saw can only be described as a fantastically subtle multicolored phosphene, completely filling every area visually available. I say it in this way because I was simultaneously losing contact with my body, I could not tell if my eyes were open or shut, although I initially had the feeling that they were darting back and forth, from side to side. These feelings and sensations built up in intensity very quickly, a matter of seconds: I can remember this feeling of building intensity up to a point, and then I was not there in my body or in time. In the 10 to 15 minutes that my body was under the influence of the drug my mind was completely referenceless, there was no way for my consciousness to limit or gauge the stimuli my being was barraged with. I remember switching to a perception where the endless and intricate phosphene was love and the energy of light. I called upon those forces within my being to realign and submit, to let go of all the cogent fears and just exist … and that innate decision saved me a lot of psychic damage. What is most outstanding about the way it feels is an inability to judge in any way, by any method of the mind … it is unconquerable, as deep and profound as a totally unconditional love that is life. What a trip, huh?”
(with 15 mg, smoked) “At about 60 seconds after I smoked this free base, I beheld every thought that was going on everywhere in the universe and all possible realities while I was wracked out with this horrible ruthless love. It scared the hell out of me. When I could see again (15 minutes later) it was almost as if there was an echo of a thought in my head saying that I was given an extremely rare look at the true consciousness of it all. I’ve never been hit this hard since then. A definite ++++.”
Shulgin’s reports are always interesting to read: Erowid Online Books : "TIHKAL" - The Continuation" by Alexander and Ann Shulgin
As a old meditator, I have played around with non dual states, and this post has piqued my interest.
Is there a safe and responsible way to source this substance?
What almost no one in the conversation is pointing out is that 27mg is a MASSIVE dose, well beyond what the clinical research supports, and it reflects a bigger problem in how this molecule is being facilitated right now.
For context, the only Phase 1 clinical trial on vaporized 5-MeO-DMT tested doses up to 18mg. Shulgin listed the upper range at 20mg. Most experienced practitioners I know consider anything above 15mg to be high.
And this isn’t unique to Bryan.
Across the 5-MeO facilitator landscape right now, there’s a widespread assumption that bigger dose equals deeper experience, that the whole point is to get someone to the white light, the full ego dissolution, the cosmic reveal.
That assumption is wrong, and it’s the core reason this space has a safety problem.
I’ve worked with this molecule myself, and nothing in 12+ years of psychedelic experience prepared me for what it does to the body (not necessarily the mind…)
My first time with 5, I shook so hard I lost track of where I was in the room. I was making sounds I’d never heard come out of my own mouth, heat flooding my chest, tension I didn’t even know I’d been holding suddenly leaving in these full-body waves that had nothing to do with my conscious mind.
That’s the medicine doing its job. Not the cosmic vision nor the white light. It was all about the nervous system releasing stored-up tension from the past years, if not decades, of life.
The real value of 5-MeO-DMT – the thing that actually changes people’s lives – is what happens in the physiology. Full release. The nervous system clearing out years of stored trauma, holding patterns, and tension that live below conscious awareness.
You can get there without heroic doses. You get there with precision, with a facilitator who understands what’s happening physiologically and who can tell the difference between a healing release and a genuine crisis, because from the outside they look almost identical.
Bryan had Dr. Robin Carhart-Harris on call and a medical team on site. Most people sitting with 5-MeO-DMT facilitators have none of that. They have someone who attended a few ceremonies and decided they were ready to hold space.
If this molecule is entering the mainstream, and thanks to Bryan, it just did in a massive way, the conversation needs to move past “how far can we push it” and toward “how do we keep people safe while the real clearing happens.”
In the livestream they said 18 mg and that was on the scale. I’m guessing that’s a typo in the original tweet.
https://x.com/i/status/2036976673384485299
This transcript outlines an aggressive, experimental framework for human longevity and cognitive rejuvenation, centered on the synergistic application of neuroplasticity-inducing psychedelics and next-generation cellular therapies. The primary thesis posits that targeting the brain’s Default Mode Network (DMN) via potent serotonergic agonists—specifically Psilocybin and 5-MeO-DMT—represents a highly efficacious, yet underutilized, modality for systemic biological age reversal and psychological resilience. The subject asserts that classical longevity interventions (e.g., caloric restriction, hyperbaric oxygen therapy, metformin, rapamycin) are insufficient for overcoming the neurological rigidity and chronic neuroinflammatory states that accompany chronological aging. Instead, the transient disintegration of the DMN using 5-MeO-DMT is hypothesized to rapidly restore a highly neuroplastic, “childlike” state, heavily modulating subjective well-being and downstream metabolic markers.
The discussion aggressively pivots to highly experimental, preclinical biotechnologies aimed at reversing cellular senescence and mitochondrial dysfunction. The transcript details active participation in autologous organoid drug screening, utilizing induced pluripotent stem cells (iPSCs) derived from the subject’s somatic cells to test compound efficacy, toxicity, and multi-drug synergies ex vivo. Furthermore, the dialogue highlights an imminent self-experiment involving autologous mitochondrial augmentation therapy. This protocol relies on harvesting young, maternal-lineage mitochondria from a familial donor, amplifying them in a bioreactor, and re-administering them via intramuscular injection to systemically upgrade bioenergetics. Additionally, plasmid-based gene therapies targeting the FOXO3 pathway via mesenchymal stem cells (MSCs) are identified as a critical future modality for whole-body tissue regeneration.
While the transcript presents a compelling theoretical synthesis of neuro-enhancement and molecular reprogramming, it is saturated with N=1 subjective anecdotes and lacks rigorous, placebo-controlled validation for its most aggressive claims. The translational gap between murine models of mitochondrial transfer or FOXO3 overexpression and safe, efficacious human application remains dangerously wide. The aggressive stacking of these experimental therapeutics introduces profound pharmacokinetic unknowns and non-trivial risks, including permanent psychological destabilization from high-dose psychedelics and oncogenesis from unregulated cellular reprogramming. Ultimately, the data presented is an exploratory vanguard, demanding rigorous, independent clinical verification to separate verified biological mechanisms from speculative transhumanist philosophy.
The following protocols are extracted directly from the transcript. Note: Several compounds lack specific dosing parameters in the source text, representing missing variables that require independent medical supervision and literature review prior to implementation.
| Compound / Intervention | Extracted Dosage & Timing | Missing Variables & Clinical Notes | CEBM Evidence Level |
|---|---|---|---|
| Psilocybin | 3 separate doses of 25 mg each. | Exact timing between doses, fasting state, and specific synergistic co-factors are omitted. | Level 1a: Systematic Reviews/Meta-analyses confirm efficacy for TRD and neuroplasticity. |
| 5-MeO-DMT | 9 mg Intramuscular (IM) followed by 18 mg vaporized. | Onset is ~10 seconds. Post-trip integration protocols and exact physiological monitoring parameters are omitted. | Level 2b/3: Early Clinical Trials/Observational confirm rapid DMN disruption and safety in controlled settings. |
| Mitochondrial Transplantation | Intramuscular injection (planned). Harvested via blood draw from younger maternal relative. | Total mitochondrial count, exact bioreactor expansion protocols, and dosing schedule are completely omitted. | Level 5: Preclinical / Animal Models demonstrating bioenergetic restoration. No human RCTs. |
| Organoids (iPSCs) | N/A ( Ex vivo tissue culture). | The exact reprogramming factors used and the timeline for drug-screening readouts are omitted. | Level 5: In vitro laboratory modeling. |
| FOXO3 Plasmid / MSCs | N/A (Theoretical implementation). | Delivery vector (e.g., lentiviral, adenoviral, liposome) and total cell counts for systemic regeneration are absent. | Level 5: Preclinical Models confirm protection against cellular injury and senescence. |
The transcript freely blends established medical interventions with bleeding-edge speculation. The ability of classical psychedelics to induce neuroplasticity, downregulate the Default Mode Network, and modulate systemic inflammatory markers (IL-6, TNF-α) is a verified clinical fact backed by a growing body of RCTs. However, the assertion that 5-MeO-DMT functions as an explicit “longevity therapy” capable of persistent biological age reversal is entirely informed speculation. The transcript assumes that transient psychological rejuvenation and metabolic shifts observed at N=1 will translate to persistent epigenetic or cellular longevity, which remains unproven in the scholarly literature.
The most severe knowledge gaps exist within the proposed transgenic and cellular therapies. While mitochondrial transplantation utilizing red blood cell membrane encapsulation has demonstrated remarkable efficacy in rescuing motor performance and reversing cellular energy deficits in murine models of Leigh syndrome and Parkinson’s disease, scaling this to systemic human rejuvenation faces massive translational hurdles. The immune system’s response to expanded allogeneic or familial mitochondria, even if maternally matched, poses an unquantified risk of severe autoimmune cascade. Furthermore, relying on ex vivo iPSC organoids to map systemic drug toxicity ignores the complex endocrine and inter-organ signaling pathways present in vivo; a drug deemed safe in an isolated “Brian Johnson liver organoid” may still trigger lethal systemic cascades.
The aggressive stacking of high-dose serotonergic agonists (5-MeO-DMT) carries non-trivial risks of inducing persistent psychosis, hallucinogen persisting perception disorder (HPPD), or triggering latent schizophrenia in genetically predisposed individuals. The subject acknowledges these risks but dismisses them for his own protocol due to extensive pre-screening.
Regarding epigenetic reprogramming (Yamanaka factors), the transcript correctly identifies the paramount safety risk: oncogenesis. Without synthetic, highly tuned “cellular switches” to arrest the reprogramming process before cells hit full pluripotency, in vivo cellular reprogramming is a virtually guaranteed pathway to teratoma formation. The data presented is highly actionable for those tracking biotech frontiers, but demands absolute segregation between therapies ready for human deployment and those strictly confined to murine models.
So far it does looks more a buzz like thing for bryan and his social media, and an experience for some. But i dont see really rationale to use it as anti aging strategy. The level of evidence is low and the potential issues are there.
Psilocibin looks safer and have much more data. But even this one is not a top tier anti aging intervention
