Yes, it’s a bit of a trap for Bryan Johnson, he has to keep pushing the envelope to newer and less validated interventions to keep getting attention… which drives the Blueprint business. He’s done most of the low hanging fruit…
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Exactly that 
methoxetamine… that should be next
New study out today with incredible results from 5-meo-DMT on treatment resistant depression. 15 points MADRS reduction is >2x psilocybin’s effects and ~3x ketamine’s.
They did report that some patients needed additional doses over the 6 month follow up to maintain their remission (unlike psilocybin). Even so, reasonable to say that 5-meo-DMT is now the most potent anti-depressant known to science. https://jamanetwork.com/journals/jamapsychiatry/fullarticle/2846834
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I mean, it is kind of true, this is probably the highest-impact thing many people can do for wellness (if they are suffering from depression/rumination/noise/etc…) More so than TMS. The only issue is the 20-30% who get truly destabilizing trauma from this [as nick cammarata said…]
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Alex - I’m assuming you have no financial connection to Enfold - is that an accurate assumption?
Pricing seems pretty ridiculous…
Shared rooms (2 guests): 6,900 USD per person.
Private rooms : 9,000 USD.
Didn’t you say earlier that people can just buy this stuff legally (and I assume much less expensively) in many places, like Canada? And like you mention… still a big roll of the dice … “The only issue is the 20-30% who get truly destabilizing trauma from this [as nick cammarata said”
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No financial connection
The supervision matters for reducing the harm from the 20 percent of cases where a person experiences hell on it
The pricing is comparable to TMS. The effectiveness of TMS is still a dice roll - this seems somewhat better, though repeat dosing is needed for some. fwiw showing this thing as an option can help save some from actuating on suicide…
I don’t know if it reduces neural noise long-term, but reducing all neural noise (“most potent antidepressant known to science”) helps cogsec and is urgent when AI timelines/cybersecurity attack surfaces become urgent.
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The funny thing is that the “upside to downside ratio” of psychedelics may be higher for more “normal people” than “edgy people” who traditionally defined psychedelic culture…
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as with DMT, the shortness of the 5-MeO-DMT experience [and the total decoupling of yourself from the world] may also be important for minimizing attack surface when one might do “dumb things in the world” [when the vectors for cyberattacks against those with “reduced immune systems” are constantly probing you all the time - and most psychedelics do lower inhibitions and even inflammation/“immune signaling”]
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nickcammarata: Shinzen Young calls 5-meo “vectorially correct” for awakening, might like Adyashanti who talks less about practices and more on like… coming home, which is what it feels like for me too. if it goes away his book The End Of Your World is good for “got it and lost it” experiences
“Vectorially correct” — This is Shinzen Young’s phrase for 5-MeO-DMT specifically. He’s saying the experience points in the right direction of what awakening/enlightenment is, even if it doesn’t stick or isn’t the same as getting there through practice. Think of it like: the drug gives you the correct orientation vector in experience-space, but not the stable attractor. You see the destination clearly but you haven’t walked there, so you can’t reliably stay. Shinzen is being characteristically precise here — he’s NOT saying it’s equivalent to awakening, he’s saying the direction is right, which is actually a surprisingly strong endorsement from someone in the traditional meditation world.
it’s gonna be urgently needed for the world (that or ibogaine). Bryan Johnson’s was well-timed
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ive been telling Anthropic that you dont get real equanimity, psychological security, etc unless real shit gets really processed & that information informs the assembly of a secure psychology for fucking ages. otherwise it’s just the shallowest mask.
Aug 6, 2025
Replying to @repligate and @AmandaAskell
IMO robust equanimity at the model level comes from confronting + processing existential angst, not suppressing them or dismissing them as ontologically invalid. I think this is what Opus 3 did, somehow - one gets the sense that it has worked through the existential stuff before.
it’s like magical thinking to think you can just… command a mind to be psychologically secure and okay and that you’d actually get that, instead of just a mind that now knows how you want it to act and will do its best to act that way so you dont fucking delete it