Review
How do you eat your ginger? Pickled, raw, tea? I shred raw ginger to make ginger tea or add it in soups, like carrot-ginger soup.
I also eat chia a lot and every day in salads, with tofu, sprinkle it on salmon or farmer cheese.
I make my own sprouts - Alfa-Alfa, broccoli and mung beans. Eat them with everything.
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I buy a lot of pickled ginger. Freeze most of it and have a small container I pinch a small amount out of each morning. Probably about 3-5 grams. I quite like ginger and there are some interesting molecules in ginger that might be helpful.
Chia are very good. However, I only try to eat around 25g a day.
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Dr. Levineās new company (Elysium) sells a supplement where you take a daily dose and two days a month you take a combination of quercetin and Fisetin among other ingredients. So they think that these two are complementary for what thatās worth.
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So many choices, that is why it is difficult not to take the shotgun approach and take a boatload of supplements every day
Quercetin:
"Anti-inflammatory effects: Quercetin has been shown to have anti-inflammatory effects in various animal and human studies, possibly by reducing the production of pro-inflammatory cytokines and oxidative stress.
Antioxidant effects: Quercetin is a potent antioxidant, meaning it can neutralize harmful free radicals that can damage cells and contribute to disease.
Immune system support: Quercetin has been shown to have immunomodulatory effects, possibly by supporting the activity of immune cells such as T cells and natural killer cells.
Cardiovascular health: Some studies suggest that quercetin may have cardiovascular benefits, such as improving endothelial function and reducing blood pressure and cholesterol levels.
Anti-cancer effects: Quercetin has been shown to have potential anti-cancer effects, possibly by inhibiting tumor growth and inducing cell death in cancer cells.
Neuroprotective effects: Quercetin may have neuroprotective effects, such as reducing oxidative stress and inflammation in the brain, which could be beneficial for conditions such as Alzheimerās disease and Parkinsonās disease."
So many choices, that is why it is difficult not to take the shotgun approach and take a boatload of supplements every day
Fisetin:
Anti-inflammatory effects: Fisetin has been shown to have anti-inflammatory effects in various animal and human studies, possibly by reducing the production of pro-inflammatory cytokines and oxidative stress.
Antioxidant effects: Fisetin is a potent antioxidant, meaning it can neutralize harmful free radicals that can damage cells and contribute to disease.
Senolytic effects: Fisetin has been studied for its potential senolytic effects, meaning it may help remove damaged or senescent cells from the body. This may have implications for aging and age-related diseases.
Cognitive function: Some studies suggest that fisetin may have cognitive benefits, such as improving memory and learning, possibly by modulating pathways involved in brain plasticity and neuroprotection.
Cardiovascular health: Fisetin may have cardiovascular benefits, such as reducing blood pressure and improving endothelial function.
Anti-cancer effects: Fisetin has been shown to have potential anti-cancer effects, possibly by inhibiting tumor growth and inducing cell death in cancer cells.
But, I agree, there is a redundancy here. I took quercetin off and on over the years, fisetin is a recent addition, depending on which way the research winds were blowing at the time. Since I am 82 and my mind is mostly intact I think I will stick with the quercetin.
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Because one of my things is acetylation of the histone I think there is a merit in taking HDAC inhibitors (Histone Deacetylase inhibitors). One of those just so happens to be Quercetin.
I collated a list of HDACi s and tried to track down their ic50 threshold. My objective is to slow down deacetylation. Not to stop it.
Here is the list
Sodium Butyrate 0.3, 0.4, 0.3, mM for HDAC1, 2 and 7
Curcurmin 25mcM
Pterostilbene 5mcM
Berberine 20mcM
Apigenin 27 mcM
Dihydromyrecein 36mcM
Quercetin 36mcM
HDA10 (Royal Jelly) 0.5mM
What I find interesting is that substances that are thought have longevity benefits are also HDACi s to me that indicates that perhaps that is one of the big reasons they have longevity benefits.
Incidentally I think Fisetin is also an HDACi, but I donāt have any idea as to the ic50. I would not want to take something with an ic50 in the nanomolar ranges, but those in the micro and milli molar ranges appear quite useful.
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I just added beta-alanine to my supplement list. I have taken it in a dose of 2mg in each of my first two cups of coffee in the morning. So far I have experienced only a very mild itching/tingling effect. Supposedly it is more bioavailable than carnosine.
My question is: Am I overdoing it on the senolytics?
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The test on senolytics (and it is in many ways trying to get senescent cells to function that is the issue - ie senomorphics) is what your minimum CRP level is. That gives a guide to your senescent cell burden (via SASP and IL-6). CRP goes up with infection so you need to do a number of tests to find the minimum.
I think the argument about beta alanine is that it converts to carnosine and carnosine needs to split to have an effect. In any event I have stopped carnosine for now as I wish to track down the tingling (some of which was carnosine).
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Maybe the way to do it is have a core group of supplements that you will always take and cycle around a second group of the āpotentiallyā does this and āhas been shown to doā that, where you hope itās doing some good but you never notice anything.
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Since I have accumulated a boatload in my cupboard that is exactly what I have been doing. My list is just showing what I am currently taking. It is just hard to keep track of the timing, with or without food, etc. That is why I try to keep my stack down to a manageable few.
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For those of you taking NR or NMN, (I am not currently taking) this is a very informative discussion with one of the experts on NR vs NMN.
This is very useful now that Amazon and others are banning the sales of NMN. For those who donāt want to watch the video. He says
NMN is no better than NR.
Though I canāt find any indication that Amazon is actually taking NMN off the shelf.
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You can accomplish the same(as NMN) with niacin (nicotinic acid) or niacinamide. And the cost is much less
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The wind seems to change direction frequently in this field.
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This is the link to the entire paper.
āUse of Carnosine as a Natural Anti-senescence Drug for Human Beingsā
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I started taking quercetin in 2020 hoping to improve my immune response, based on the recommendation from medcram. It still seems helpful during flu season. It doesnāt prevent you from getting the flu but some studies have shown that it helps reduce the severity. Whether it has any anti-aging effects seems to be a more difficult question.
Of all the new supplements, I am most excited about the potential of urolithin A. Donotage has started selling it (quickly sold out), which I hope will drive down the price.
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So 200mg of Melatonin, sometimes chewed and put under the tongue to get rapidly into the blood stream?
Can you say more about your belief in Melatonin and your reasoning behind (and timing of) the dosage?
Thank you
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Agreed here 100%. I take extended release niacin at 1000 mg per day per this study. I get flushing occasionally but not often. I get tired of people who say how bad it is for the liver in high doses. I have seen no recent studies that prove this and my own liver enzymes have never varied. Iām sticking with niacin over NMN and NR.
https://www.sciencedirect.com/science/article/pii/S155041312030190X
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Supplements worth taking in my opinion of course:
High quality fish oil
Astaxanthin (potent antioxidant , algae create astaxanthin when they are under stress, it protects them in hard times so we ingest astaxanthin, it possibly protects us as well).
Vitamin d3 with K2 , great for the heart, muscles, bones and skin.
Aged Garlic ( it can reduce plaque in the arteries, lower blood pressure etc has lots of studies to back it up).
Small dose of lithium.
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Even if it ages us more rapidly, black garlic, especially from Thailand, is wonderful. I never have a salad without lots of it on top.
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