Which supplements do you think are still worth taking?

[Beth]

Thanks for the heads up!

We have a housing crisis here, yet a lot of lumber comes from Canada. This is going to hurt so many people.

[Steve_Combi]

@Beth

a lot of lumber comes from Canada

It keeps our beaver population busy

[relaxedmeatball]

For me:

Magnesium oxide - up to 750 mg, which is where my bowels get loose. This is taken for some supplemental Mg, but actually mainly for gut mobility

Creatine - muscle and brain benefits are pretty well described now

Fish oil - I don’t get enough through diet

Vitamin D3 for 6-8 months of the year

A very boring list. I would almost never do plant extracts, herbs etc because there’s no real way of knowing he purity, effectiveness. I’d rather use pharma products which are better studied and where the product quality is controlled.

[Steve_Combi]

@relaxedmeatball

I’d rather use pharma products which are better studied and where the product quality is controlled

Me too I do take a lot of supps though

[DeStrider]

Talking Docs talk about the Vitamin D3, Omega 3s and exercise study.

How to reverse aging - The Power of Epigenetics, Omega-3, Vitamin D & Activity

[Agetron]

Minimum B-12 might not be enough to maintain DNA health…

When I did my first TruMe methylation test… and had a differential of 13 years biological to my chronological age. Anti-aging specialist Dr. Yelena Budoskaya was fascinated by my results. She warned me to up my B-12… because the rapamycin might negatively affect it. Started daily supplementing B-12.

Been a high normal on blood tests for B-12 ever since… past 4 years.

Link: https://scitechdaily.com/scientists-just-found-a-major-problem-with-vitamin-b12-guidelines-and-your-brain-might-be-at-risk/

Check your B-12 often as a rapamycin off-label user.

[DeStrider]

How much B-12 do you take?

[Agetron]

Past 4-years I have used the Spring Valley Walmart Extra Strength B-12. 3000 mcg gummies. Cost around : $17.50.

I take 2 gummies at bedtime. Blood tests says it all. Last test… off the charts.

My number 1123… top normal 1171. Nailed it.

[AnUser]

FYI: B12 isn’t that precise to actually measure B12 levels in tissues… homocysteine and metylmalonic acid (MMA) is required to know true B12 status, and it’s possible to be deficient with normal serum B12.

What are your homocysteine levels? What have you done to reduce it? Why isn't it part of PhenoAge or aging.ai clocks?

MMA and HC can diagnose B12 deficiency despite normal B12 levels: There are two enzymatic reactions that are dependent on vitamin B-12. Vitamin B-12 is required for methylmalonic acid (MMA) to be converted to succinyl-CoA, and in combination with folic acid, for homocysteine (HC) to be converted to methionine [9]. Therefore, MMA is clearly more specific to vitamin B-12 deficiency compared to HC. A deficiency of vitamin B-12 at the tissue level can lead to elevation of both MMA and HC [1] even when serum vitamin B-12 concentrations are within the reference values. Elevated MMA and HC levels together have been found to be 99.8% sensitive for diagnosing functional vitamin B-12 deficiency [10], which is defined as elevated MMA and HC levels despite normal vitamin B-12 levels in asymptomatic individuals [11–13]. Therefore, using serum vitamin B-12 testing alone may under-diagnose the deficiency of this vitamin. MMA and HC have been identified as early markers of vitamin B-12 deficiency i…