I had GERD with daily pain for 10 years no matter how many poi’s I popped.
Completely cured it within a couple of weeks when I stopped consuming seed oils.
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I was diagnosed with pre-cancerous dysplasia in my esophagus so I need to be vigilant. I’m all better now with treatment but I have to do annual endoscopy checks to make sure I don’t have a recurrence. TL;DR catching Barrett’s Esophagus and other dysplasia early has like a 98% or higher cure/treatment rate but if left untreated, it’s got a really high mortality rate so I was super lucky to catch it before it got bad so staying on PPI’s are something i have to live with
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What were the symptoms so that others might also avoid the same? I had a colonoscopy done and found pre-cancerous polyps. Removing polyps is a cakewalk compared to removing cancer. An ounce of prevention truly is worth a pound of cure!
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Diet is also crucial here. Buy the book Acid Watcher Diet.
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One interesting thing is that probably everyone here, myself included, would list rapamycin as a supplement that is good for everyone. That is why we are here. I think if you were to ask the same question among professionals in the longevity space, rapamycin would be a controversial choice.
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I think most people would benefit from sulforaphane supplementation.
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Rich Miller says they couldn’t get Sulforaphane to work (1:08):
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You’re certainly moving in the right direction… but you can still cut back further.
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This.
Though I don’t take magnesium because I eat copious dark chocolate and avocado.
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Well, I am stopping my Acarbose supplementation. On my diet which is roughly “South Beach” by natural selection, I am experiencing too much gas and unpleasant lower digestive problems to the point it is just not worth it to me to continue with Acarbose.
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is a bit too much for me. Magnesium depends strongly on your diet and your country.
Vitamin D3 too. A south italien who eats >3 days a week fatty fish want need it.
Arcabose is a nice one - in therory. But I am unsure if I would try it even if I was a hermit and want to playing the trumpet all the time.
But I really like the idea creating a supplement list with a short description why someone is taking a supplement.
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More reason to take Omega-3s from a Mayo Clinic Meta-analysis involving 135,000+ individuals.
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I’m a green tea fan - I drink a 1.5 litres a day, cold brewed (just put a teabag in my drinks bottle).
I do it for it’s anti-inflammatory and probable senolytic affect. And because the observational human data shows a clear correlation to lifespan and healthspan
https://doi.org/10.1016/j.hnm.2022.200149 An update on healthspan and lifespan enhancing attributes of tea amidst the emerging understanding of aging biology
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I also drink green tea… but it failed the ITP
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Thanks for posting that. Point taken… that although there was some longevity increase from Green tea extract in that study the p value was .39 in males.
I’m basing my intake on an earlier study which showed a stat significant 6.4% longevity increase. The effects of tetrahydrocurcumin and green tea polyphenol on the survival of male C57BL/6 mice - PubMed
And also the fact that in midlife the ITP data showed a statistically significant survival boost from GTE. They hypothesized that: “Nonetheless, the pattern of survival … are consistent with the idea that this agent might reduce mortality rate at early ages while at the same time increasing it at later ages.”
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All site data does look like mean lifespan vs maximal life span may be up slightly – but may not be statistically significant – I like wise do green tea matcha daily.
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I think it’s important to note that the reason they couldn’t get sulforaphane to work is because it is unstable and thus difficult to formulate into their chow so the mice are actually consuming a known dose. He doesn’t fundamentally think it’s a non-starter.
A French company manufactures a stabilised form of sulforaphane called Prostaphane. It still needs to be kept refrigerated so maybe still some challenges to doing an ITP with it but I sure hope they try.
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So to summarize the list which could be useful to most people beyond Rapamycin (looking for corrections):
o. Vitamin D (I take 5k units/day)
o. Vitamin B3/12 (I don’t take, but probably just laziness)
o. Vitamin K2 (I don’t take, but probably just laziness)
o. Creatinine (I don’t take, but eat sufficient animal protein including liver)
o. Selenium (I don’t take but eat Brazil nuts, not as a supplement)
o. Magnesium (I don’t take but probably just laziness)
o. Omega-3 (I’m not taking this and never fully understood this because 3g of fish/krill oil per day is a drop in the bucket versus the fats I eat daily, so how does this move the needle? Also, I’m careful about not eating seed oils, and believe my intake of omega-3 vs 6 is probably pretty decent)
o. Metformin (I’m not taking but I am trying citrus bergamot because of high LDL from doing a “temporary” carnivore diet which appears to have muscle-building benefits, but am considering just taking metformin instead — even if LDL falls — because of possible longevity and atherosclerosis / cancer protection)
Supplements there doesn’t seem to be consensus on (not that they don’t work, only that people didn’t massively chime in supporting them):
GlyNAC (I’m taking low-ish dose but don’t see any impact)
fisetin
spermidine
CoQ10
Boron
Fiber
Collegen
Acarbose
astaxanthin
Hyaluronic acid
Melatonin
@RapAdmin : does this make sense to try a vote on these? — list a huge number of supplements and we can check off which we take (or which we think are effective)? Then you can use the data to issue a press release to market your site/work, or even a research paper if you get enough responses.
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I think we already did this mostly… please see the survey here (scroll down the the supplement section) and you can see what people are taking (and please respond yourself to the entire survey / poll if you have not yet): Rapamycin User Survey #2 - Please Respond
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