Certain biomarkers in middle age and late middle age within certain ranges predict higher odds of reaching 100 years of age. Glucose should not be high, uric acid should not be high (very important!), creatinine should not be high, liver lipids should not be high. Avoid too low iron - anemia. Inflammation markers should be low. Kidney and liver health are very important. Interestingly, blood lipids that are low do not predict higher odds of hitting 100, instead, moderate and even somewhat higher levels for the win.
Blood biomarker profiles and exceptional longevity: comparison of centenarians and non-centenarians in a 35-year follow-up of the Swedish AMORIS cohort
A pop sci write up:
Long-lived people share very crucial blood biomarkers, giving scientists anti-aging hints
“Small numbers, big weight
When participants were sorted into five groups for each biomarker, patterns starting popping out. Folks in the lowest bracket for total cholesterol and iron were less likely to hit 100 than those sitting midrange or higher.
Meanwhile, creeping levels of biomarkers like glucose, creatinine, uric acid, and several liver enzymes quietly clipped the odds of joining the century club.
Uric acid told perhaps the clearest story. In the group with the most modest readings, 4 percent reached triple digits; in the highest group, only 1.5 percent did.
A gap of 2.5 percentage points may look small, yet across whole populations it translates to thousands of extra birthdays.“