What Questions about Rapamycin do you have for Researchers?

#16

there are different ways in theory to do this.

  1. take metformin the first 72 hours after rapa, to “double up” the effect, and deal with any hyperglycemia side effects from the rapa
  2. take metformin every day independent of rapa dosing
  3. take metformin the 2nd half of the week (if doing weekly dosing) to cover the interval when rapa is at its lowest

any thoughts on the pros/cons of these approaches?

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#17

Hi, when are you planning to send in these questions? Looking forward to your interview :slight_smile:

#18

New results are due out from the NIA ITP program studies very soon… The acarbose and rapa study, etc.

I am in contact with the researchers and hope to interview them next month. But more generally i am just trying to get questions that i can pose as appropriate for different researchers i speak to going forward.

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#19

Oh wow, I look forward to the new results. I feel like in some ways those results may also generalize to any (sglt2 or keto) + rapa

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#20

Yes, it does seem that would probably be true given the key functions of both those drugs. I will discuss this with the researchers.

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#21

Adding this question to my question list for rapamycin researchers. If you have other questions - please add them below in this thread…

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#22

What do we know about rapamycin’s half-life in different tissues?

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#23

I’m taking Rapamune… does this mean I require a lower dose than people on generics?

#24

What if any recommendations for adjusting dosage by body weight? 110Lbs Female vs. 180Lbs male?

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#25

I’ve not seen any human research/clinical trials with rapamycin where they do the calculations of mg/kg for dosing. Instead its always simply a 5mg or 10mg dose. For example see these studies here.

If you want to do the calculations yourself - you may want to work from, and adjust for (based on biological differences… and I will ask the researchers about this also).

The dog rapamycin trials (TRIAD) at university of Washington is being done at .15 mg/kg in the dogs. Most people I’ve seen using it are in the range of .08 to .12 mg/kg dosing. I’m currently testing .19 to .25mg/kg (on more of a 10 day schedule or so). But I’ve been using rapamycin for 2.5 years now without issue - so I’m not the norm.

If you’re new to rapamycin, I think the safer option is to start low, start slow (e.g. 1mg/week and slowly increasing by 1mg/week), and then pause at a lower dose for a few months to see how you react, and do blood testing to check on key blood measures.

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#26

Thank you! I will take it slow!

#27

A related discussion on twitter:

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#28

This is an interesting study and female mice on dosage…

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#29

Female mice seem to respond much better than male mice (in terms of dose/response for longevity). The researchers like Matt Kaeberlein have said that they don’t see the same effect in other mammals or humans.

#30

Males just need higher dose for equal effect.

#31

Rapa and triglycerides—I remember seeing some info that rapa tends to elevate triglycerides what is the experience with this?

Thanks.

#32

Hi, in some people yes, I’ve heard that rapamycin can elevate triglyceride levels. I’ve seen mine go up about 30% since I began taking rapamycin and I’m now looking at taking a statin to help with this, or the PSK9 inhibitors. Have you experienced this? What details do you want to know in this area?

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#33

Here are my questions for the researchers:

From a mechanistic standpoint, do they think alpha-ketoglutarate (or any other supplements/medications) may have complementary/additive beneficial effects if combined with rapamycin? Dr. Brian Kennedy may have the most knowledge regarding alpha-ketoglutarate, in particular.

For longevity purposes, is the rapamycin peak blood concentration (Cmax) or Area Under the Curve (AUC) presumed to be more important?

What do they consider to be the most important adverse side effects when trying to ascertain appropriate dosing levels (as opposed to the expected rapamycin effects which may actually be longevity promoting)? Is it increasing HOMA-IR, anemia, decreased testosterone from baseline, hyperlipidemia above a certain threshold, decreased WBC below a certain threshold, etc.?

Do they suggest periodic washout periods (e.g. one month or more completely off rapamycin) to “reset” the system?

Thank you!

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#34

Thanks for reply.

I ask because I’m considering rapamycin but my triglycerides tend to run high and I have concerns about statins.

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#35

Any specific concerns in regards to statins?