Just saw this. Interesting.
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iron levels are not a good thing which is verified many places. At most esp older people should have none or only very very small reserves.
Though anecdotal, I have realized that 1-3 days after I take rapa i tend to be stronger physically, i.e. in cases where i can barely do 10 repetitions of a certain exercise, 1-3 days after rapa i can do 13-14 repetitions of same exercise. Don’t know about muscle growth since I’m not interested in that. Interesting to hear if anyone has realized such effect?
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Interesting observation. I continue to do strength training about 5 days/week and have not noticed any noticeable difference(s) following my weekly dose of rapamycin.
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Same for me. But I do have less joint pain… unclear if the joint pain relief is from rapa or red light /IR lamp therapy.
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If you start with the idea that Rapamycin increases autophagy which improves the ATP/O efficiency of cells and as a consequence translation improves any effect should be gradual.
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Joseph,
Regarding rapamycin’s ability to reduce inflammation. You might find Matt Kaeberlein’s personal experience of interest:
A longevity researcher takes a $1 drug to slow down aging, and he says it worked to treat his joint pain
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Thanks. This story is why I’m here. I hope for more but this is the primary target.
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With rapamycin I can increase weight on machines 10 pounds every 3 months. Kinda plateaued recently.
65 years old and I weigh 181 pounds…and I can fly chest 175 pounds. Pull down … and pull to me 165 pounds. 2 sets of 20 pull-ups.
Definitely stronger… but look shredded.
Can even arm wrestle much younger guys and win easily.
Much stronger.
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Same here, very strong for my age.
Another anecdotal but fun fact (which may or may not be related to rapa). Couple weeks ago i met a dude we grew up together but haven’t seen him in 3-4 years. He used to be exactly one inch taller than me in our youth. Out of nowhere he goes, you seem taller than me, how can that be I was taller than you? to which I replied I was actually taller than you, but you used to cheat when measuring up LOL. Anyway, I know that some people shrink more than others as we age but can it be that this sucker rapa reduces the old age shrinking of people also? I started Rapa 3-4 years ago for a while then stopped and started few months ago again, and I don’t think I’ve shrank much, if at all. Would be interesting to know if anyone doing rapa for over three years if they seem to think the same.
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I think rapamycin works for joint pain. I am 82 with no joint pain whatsoever, except for some right ankle pain when walking and that is from screwing it up running and playing tennis on hard surfaces.
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I’m a believer in the healthspan power of rapamycin and I agree that rapamycin works for joint pain but I think it is somewhat ironic that people “buy in” because of Kaeberlein’s shoulder story. Its pretty unconvincing to me for a number of reasons including that he is a rapa researcher and thus incredibly biased. His pain relief could easily have been placebo effect (which I think he concedes) but I doubt that too. I think the affect of rapamycin on his shoulder and other’s reports of its effect on joint pain in general are likely only indirectly related to its longevity effects. Kaeberlein would likely have had the same result with prednisone and certainly with a cortisone injection. I do think that long term inflammation suppression is likely a key feature of rapamycin’s longevity affects but I think most short term wow affects of rapamycin (in dogs and humans) is more due to suppression of inflammation and thus acute relief of pain. Maybe I’m splitting hairs here?
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I don’t know how effective rapamycin is for reducing joint pain. My personal experience is this: At age 80 I had some serious side effects from the Pfizer covid vaccine. Before I had the vaccine I felt minor arthritic pain in my hips and knees after the shots I got major joint pains and I had to use a cane for a couple of months. After taking rapamycin at 20mg with GFJ and EVOO once every other week, the pains went away rather quickly along with my age-related “essential tremors”. Did the rapamycin do it? I don’t know, but it was quite a coincidence.
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I’ve read it’s good for bones so your experience makes sense. I’ll try to find a link where I read about the bone benefits. Edit: here it is fwiw.
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Thanks blsm,
Great article. In my own pragmatic way, I could almost certainly feel that my bones felt better/healthier when on Rapa, but this proves it. Ok now can someone tell me how to reverse some of my white hair hahaa (though I don’t have much) but if I could get rid of it then I’d be as good as new LOL
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Nah, no coincidence IMO. It’s definitely your regimen of rapa
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Maybe a bit off topic, but found this interesting: btw, I rarely do more 15 minutes of heavy weights, and or 300 yards of sprint.
16.5MILLION Americans at risk of stroke from EXERCISING too hard, study suggests | Daily Mail Online
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Yes when I work with my trainer day after Rapa definitely more reps, push-ups much stronger.
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I made it to 6 mg and started getting killer headaches and feeling generally achy and unwell. Going back down to 5 mg didn’t help much. Lower gut was also very off.
When I went back down to 4 mg, I started feeling pretty well again. My doc says the dose is different for everyone, and the only way to find it is trial and error. I thought I may be a person who needed more/more frequent dosing because I have the ultra rapid metabolizer gene variants per Genomind, but that doesn’t seem to be the case with Sirolimus (for me, personally).
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also discovered recently Duloxetine is also used for pain management Duloxetine for treating painful neuropathy, chronic pain or fibromyalgia - PubMed (2014)