Set aside the whole Resveratrol debacle, the hype around NAD precursors, and some of the negative vibe of Dr. Sinclair’s companies and research as of recent.
But if you look at the Sirtuin family is there any exciting research around activating these molecules via new interventions or mechanisms of action other than NAD?
I have seen some recent excitement around SIRT6 in particular but it is hard to filter relevant data.
It feels in many ways that people are abandoning sirtuins as a target of interventions largely because of all the Resveratrol issues.