I’m on a rapa hiatus for a few more weeks thanks to vitreous humor detachment in my left eye. I have to wait total of 6 weeks to make sure it doesn’t turn into a retinal tear, then I should be in the clear. I figured if I have any kind of “wound” per se, I wouldn’t want to be inhibiting mTOR(?)
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I don’t know if we have a thread for reporting our results, but here are mine after starting rapa in early October, 2021. I last had a blood panel 10/12/21, and my Levine phenotypic age (through Lustgarten’s spreadsheet) was 53.14, 4.4 lower than actual age. Now, on 2/4/22, my phenotypic age is 48.69, 9.2 lower than actual age.
So in just 3.5 months, I became 5 years younger. Most of the improvement is accounted for in improved red blood cell distribution width, but my liver function numbers (including alkaline phosphatase) also improved.
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Thanks for posting. Great to see the positive results. What medicines / doses have you been using during the period prior to the blood test - Rapamycin, Canaglifozin? other?
Just rapamycin, ramping up from 1mg / wk (no GFJ) to 3mg/wk (with GFJ) over the first 8 weeks during the time between the two tests.
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I just ordered two of the above sirolimus whole blood tests from LEF. I’ll post the results.
Confirming others’ experiences: you have to call customer service, provide the Labcorp test # to a specialist at LEF, takes about 10 minutes.
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I can now attest to the effectiveness of my supply, having just got a test result for peak sirolimus of 17ng/mL.
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Thanks for sharing, EnrQay. Was this peak result at a dose of 3mg/wk of Sirolimus (with grapefruit juice protocol)? Are you taking it with a source of fat or on an empty stomach?
The trough was 3mg/wk, while the peak was 5mg/wk, both with whole grapefruit. In both cases, I took the rapa at the same time as a fatty snack of peanuts and a fatty hot chocolate.
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I’ve been using Ulta Labs (ultalabtests) for ordering tests for 5 years now. Excellent prices! They work with Quest Diagnostic for a draw fee of $8.
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Wow - really, those prices are amazingly low. They are much lower than the already low Life Extension labs pricing - again, just a front end for Quest or Labcorp.
I priced a few tests that might be of interest to people here, comparing it to my default, walkinlab.com (which partners with the labs Labcorp and Quest). Mostly, ultalabtests is significantly lower, and I see an associated lab site as close to me as Labcorp and Quest.
sirolimus: Ult (standard order, so it’s a bit easier to order) $118, LEF (special order) $99
CRP-hs: Ult $29, WIL (LC $58, Q$32)
standard lipid panel: Ult $21 , WIL ($28)
Complete Blood Count (CBC) and Comprehensive Metabolic Panel: Ult: $38, WIL(LC $46, Q $44)
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I am almost ashamed to say, but here in Canada, I am getting my Sirolimus tests done for free. The government must deem Sirolimus associated with cancer/transplantation, and covers it. So I am flying under the radar with my very supportive functional medicine doc (NOT regular mainstream family doc who I fired years ago).
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Wow - thats fantastic. Something every Canadian rapamycin fan will be glad to know.
It would be great if you could do a series of blood sirolimus tests after different doses and at different times (e.g. 1 hour after consumption, 12 hours, 24 hours…)
You could get a really good idea of what your dose/response curve looks like and how different compounds like grapefruit juice change that curve.
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Yes, that’s my plan. Will post the outcome.
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It seems only appropriate that since Rapamycin was discovered by Canadians, that Canadians should be the ones pushing the clinical applications for anti-aging forward with additional testing like this 
In all seriousness - I do think that countries like Canada actually are the best positioned to invest in something like rapamycin, in research and in rolling it out aggressively to their population to slow the burden of age-related dysfunction and disease, because ultimately the biggest beneficiary would be the Canadian people, and the healthcare budget. It would seem that there is the incentive to move the fastest in countries that have universal health insurance.
Of course - there is the problem of the slowness of government, but Canadians should really push it.
For those interested - there is a book on the initial Canadian expedition to Easter Island that found the bacterium which secreted a compound, which we now call Rapamycin. I found out about it from Laura Minquini’s article I link to on the home page.
“Dreamed up” by McGill University’s surgeon Stanley Skoryna and microbiologist Georges Nó grády in 1962, the project was to provide medical and biological profiles of Easter Island (also known by its native name Rapa Nui), as the “before” condition prior to the opening of an international airport on the Island.
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Thank you for sharing. I knew there was a Canadian connection, but not all this rich history.
Without long term RCT trials, mainstream doctors are never going to script an “immunosuppression, transplant, anti-cancer” drug. Really bad optics, massive liability concerns without an FDA backing. No mainstream federal agency is deeming aging a “disease”.
And these trials will NEVER get funded for Rapamycin…off patent, no financial incentive for anyone connected to Pharma. Only a patented Rapalog “might” get a trial funded, but it’s a long way to prove median/total lifespan!!
DNA methylation, pheno-age, or some other intermediate primary end point trials might get realized when critical mass self-hacking AND medical community supports.
At least it looks like we might be starting with dogs…go MK!
Not holding my breath.
Another reason why this drug might be best adopted in Canada - where the legal industry is not so omnipresent as in the US. And, even in the US, you already have many doctors prescribing rapamycin for the past 5 years, with no significant issues…
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I don’t know anyone who has even heard of Rapamycin in my circles. My very supportive doc was like “wow, seriously, you want to take this”.
We follow the US when it comes to drug approval or emerging medical dogma…we are a rubber stamp. We don’t stick our necks out.
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Thats equally true down here in the US, even in San Francisco, except if you stray into the biotech communities.
How do you make topical from rapamycin? Would love to make some. Thanks for your formula.