What blood tests are people taking?, Any rapamycin specific ones?

#34

I got my 2 LEF sirolimus (??) tests back.

I’m DIY on the 2 week protocol, some chinese powder cut per instructions + indian 1mg sirolimus pills as:

day 1 and day 2 each are: 4mg of sirolimus pills + 6mg of home made powder for each day.

I combinded a higher probability 1mg pills with a questionable purity chinese powder and my questioonable dilution to assure I’d be taking at least the 8mg of the 1 mg pills.

I tested on day 3 = 4.8 ng/ml which is higher then others reporting in the 3.0 range so my theorectical 20mg total does might be what I’m actually taking.

Tested again on day 13 and the test said <0.5 ng/ml (undetectable),.

My view is success. I’ve got many years supply and recently bought another 2-3 yrs of 1mg sirolimus from india for around $350. Seems I might have added to that order a few years of dasanitib for the senolitic doses which I’m doing 3 days per month of 70mg dasa and the 1.5g fisetin, 1.5g quercitin. I did 150mg of dasa once and I felt insanely rotten that night, so I backed off. Dasa can cause blood clots (+/-) so no need to kill myself over an anti ageing protocol.

Effects to report; none that I notice. ;( LOL, I’m prior taking a bunch of anti inflamatories, spermidine etc etc, the *acetam nootrophics so for me it may not be the clean out and crisp up that others feel… all TBD, and in time a few DNA/methalation blood tests for phycial age… TBD

Tnx to all!! Curt

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#35

Thanks for the details of your protocol. How long did the LEF tests take to come back?

#36

Via Life Extension (IMHO a great org) about 5 days to get the sirolimnus blood test back. In general blood tests via labcorp then LEF are taking longer to come back. No doubt staffing etc in the labs in the back end plus its the holidays. I have a male ultra panel now going on 2 weeks and not come back. I called early this week and some aspect was being waited on… We are in a new world of supply shortages and delays.

I was reading these folks blog and this guys protocols.

He posted his history and stuff he takes in this pdf (long). https://www.aginginterventionfoundation.org/AgingInterventionProgram.pdf

half way down he mentions (his opinion) that senolitics including dasanitib should not be done that often, a few times a year. My (DIY) of once a month may not have good science behind this frequent. Nor my lifting Dr Greens up to 20mg of rapa every 2 weeks. I think the logic of 2 weeks vs 1 week makes sense from a decay perspective and my blood test at 13 days found undetectable rapa. But 20mg may not have good sceience either… Just mentioning to folks…

But those guys youtube (posted here a few weeks ago) is quite an interesting collection as is there website:

https://www.aginginterventionfoundation.org found off https://www.anti-agingfirewalls.com
and video watched off: Younging - Triggering Ancient Mechanisms for Rejuvenation - YouTube

DIY anti aging eats time and effort like … well too much time.

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#37

like Advanced Oxidative Stress Profile - Help Center and ION® Profile - Help Center

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#38

Hi, which Indian pharmacy did you use?

#39

See the list we’ve pulled together from everyone’s recommendations - here - list of reliable online pharmacies selling rapamycin.

#40

Buying any drug from india is just as complicated as buyug from China (which I have done) using alibaba and similar chinese sites.

Buying from india starts (for me) with; indiamart.com you create a login, verify, then post what y9ou are looking for. Then you get a bunch of responses, mostly all automated. It does NOT make you feel like each response is from some responsibile company. I suspect each of those people are gig workers at home shippping what stuff they can channel on their wholesale / runner channels. Not very comforting but its my guess of what I’ve experienced.

Here’s the contact from my last 2 buys (different suppliers). Both are selling sealed strips of sirolimus 1mg. Counterite product in this drug?? I have no idea. I used my body as the test vehicle and did the $99 LEF.org / labcorp test to verify there was rapa somewhere in what I took. Sorry for seeming lax or un professional top US pharma source speaking. Its just what I see and am guessing.

Most recent: Mahesh Sonwane
G.P.Pharma International, Dadaji Dhuniwale Nagar Savner Patansavangi, Nagpur - 441113, Maharashtra, India

maheshsonwaneg@gmail.com, [dineshvatyani25@gmail.com]
[https://www.gppharmaint.com/]

oldest: BonHoa Health bonhoahealth@gmail.com / BONHOA support@bonhoapharmacy.com

=== The process goes; india/china
get on the portal; state what you are looking for, sirolimus, 500 total 1mg pills, shipped to USA, what is your best price? Both platforms quote varying prices for the same product, it can’t hurt to nudge for the best price.

Last price paid; $350 for 500 1mg sirolimus. $100 for 60 pills 50mg dasnitib. I only take the 50mg for each of 2 days. I had a bad experience at 100mg (maybe it was higher…) either way dasnitib can cause sides effects at least once for me.

The china powder rapa was around $400 for 5 grams (or it was 4gm) which is 4000 1mg doses once diluted per instructions somewhere here or on the other anti aging board. Store in the freezer.

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#41

Was that price from GP Pharma? For their Sirokem Sirolimus?

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#42

Curt, It would be great if you would supply the names or links to your sources of sirolimus, etc. Thanks, Jay

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#43

Thanks for the detailed sharing
Sirolimus 500 tablets are A Lot. Have you been intercepted by customs?
I heard people said that too many drugs (>200) in one shipping may be intercepted by customs.

Chinese rapa powder is cheap, there are many vendors in Alibaba and Taobao.
But the concern is it’s for research use, not for drug.
Even their purity is ≥98.0%, we don’t know what’s in the rest 2%.

And this 2% may be some very toxic substances, that can irreversibly damage our organs, and permanently accumulate in our body and tissue.
If people want to live more than 120 years, it’s not wise to accumulate unknown substance in our body

However, $350 for 500 1mg sirolimus is a nice price in IndiaMart, thanks for sharing experience, I would like trying to buy sirolimus from this vendor too in future

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#44

Yes. via Mehesh off indiamart. I’d see if emailing the emails above get to him. I perfered buying metoformin and other items off sites like alldaychemists.com. Seems more legit But allday doesn’t sell sirulimus or dasinitib etc, nor have I found a an official looking website selling this stuff.

I just pondered, as an ex technologist, that selling obtusely off sites like indiamart/allababa without pictures or item names prevents google to find sellers of prescription only drugs and thus the FDA etc to send cease and desist. Thus keeping sales semi under ground via writing back and forth on exchanges with these questionable middle men.

Jay, there are no “urls” per my above theory. You might email the above emails. OR go on indiamart.com and ask for 1mg sirolimus …

It does have a back-alley feel I agree. My blood tests show that at least one buy did contain rapa. At only $99/per rapa test maybe do this test for each batch bought. Get blood drawn the day after your dose. Just theory and just tossing this tactic out there.

Good luck to all, curt

Its the DIY world we live in. ;(

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#45

Lee re 2% highly toxic impurity. I totally agree.

Just my thinking;

  1. Sugar is highly toxic and injurious yet the average American consumes 50gr/day x 30 = 1500 grams per month.

  2. Glyphosphate (roundup) is everwhere even in trace amounts in organic due to air borne drift. We consume untold mg / mo especially if you eat conventional or live near ag areas like CA central valley.

Do you eat peaches? its the most sprayed fruit where it soaks in and can;t be washed off. Apple juice contains residues you don’;t want (plus HFCs).

  1. 2% of 6mg/week x 4 x 0.02 = .00048 gm or 0.5 mg / mo of something. This is relative to how many gms of other bad things we unknowingly consume (in my guessing).

  2. how much cyanide in apple seeds - Google Search

Apple seeds contain 0.6mg of cyanide per gram of seeds. Ever eat apple seeds?

This is bordering on silly, certainly hyperbole and only my views re risks. But reflecting on it all, I’m moving from chinese powder to indian 1mg pills. I just wished I would have NOT mixed all my chinese power up into diluted mix so as to have some pure powder to make topicals with… Grrrrr!

Good luck to all.

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#46

I used Kachhela Medex at Indiamart in September, 2021. An excellent price for Sirokem 1 mg ( Sirolimus 1 mg ) tablets 300 pills for $ 90 plus shipping charges $ 40. It took about a 3 weeks to arrive, with no problems in shipping. I can’t attest to the purity, but I’m planning on the LEF test for plasma sirolimus soon.

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#47

Thanks for the detailled reply, I get my Rapa doctor prescribed from any Belgium pharmacy,
I tried chinese dasnitib but felt nothing, will try it from Mahesh Sonwane now

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#48

InquilineKea, I can see the names of these tests in the results you shared- beta galactosidase, and NAD, GSP, and Oxidative stress. Are there others on the report that are not visible? I can’t see the details on the graphics. Thanks.

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#49

@Ludovic Can you please explain how you do this? I hear from many europeans that they don’t know how to get rapamycin prescribed, or how to buy it. Any recommendations you can give on what is working for you would probably help a lot of people here.

Thanks

#50

Hi RapAdmin, FWIW my rapa+daca from India arrived today. Approx 4 weeks travel time. For the EU’s folks; no prescription needed. I wired funds from my bank (tiaabank.com) using the complicated international wiring instructions given from (below) and my bank sent the funds. LOL!!! Not all banks are easy to work with re sending wires, certainly not international wires. I so this for real estate purchases often enough to its not uncomfortable for me. I admit: don’t buy an amount of $$ you can;t stand to loose seems like good advice… Many trip wires in this path where you might loose your funds, shipment etc. For me; many Indian purchases of other things, 1 China (alababa.com +/-) purchase all came. Zero losses.

order of 50 (x10) strips of sirolimus ($350) and 2 bottles of 50mg dasanitib (200x) ($200). That was 500 pills of 1mg rapa plus 200 50mg of dasa (senolitic main ingredient) for approx $550.

From: G.P.Pharma InternationalNagpur, Maharashtra / Mahesh Sonwane

both bottles had foil seals over the top, rapa where all sealed 10pill packs.

via indiamart.com. See above for steps to hook up with vendors on indiamart.com.

I’ll store in the freezer with my other rapa/dasa ingredients. I bought this batch on a lark to experiment with is India back in business shipping this type of product with their covid etc… They are at least for this shipment.

rapa
rapa720×1280 217 KB

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#51

Thanks for the update. Good to hear you were successful in getting what you ordered.

#52

I get my Rapa prescribed through my family doctor, but you have to see this as an endpoint of a journey me and my doctor took to maximizing my health. In that journey I followed / tried out every health advice he have me and did every test he suggested. My anti-aging journey started 4,5 years ago when at 39 year of age, I started having lower energy ( I do weight training 3x per week plus 1 boxing and 1 cardio training). I went to see an anti-aging specialist and he started me on TRT plus recommend me to optimize certain blood test results like vitamin D, zink, selenium, magnesium. From then onwards I was getting my blood checked every 4 months; once from my specialist, once for my annual check-up at work and once from my family doctor. So every 4 months I discussed these results with my doctor and tried out his health recommendations or something I wanted to try like keto, ozone theraphy, fasting, metformin. So my doctor knows I am 100% committed to living as healthy as possible and he sees the results. I now go to my doctor at least every 2 months to talk to him about my and his health, and so he’s more like a friend now.

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#53

I finally got my trough levels of rapa tested last week. 6mg/week generic rapa from US pharmacy, and I also take berberine 500mg TID (which should increase rapa levels by inhibiting cytochrome p450 3A4). Anyway, trough levels in the morning before my weekly dose (Day 7 after my last one) were zero/undetectable. I have another order in to check my peak levels, so that should be interesting. I’ll likely wait until the omicron wave has passed to go back to the lab, though.

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