What are your homocysteine levels? What have you done to reduce it? Why isn't it part of PhenoAge or aging.ai clocks?

This is one area where vegans do worse than non-vegans despite vegans having lower methionine but I wish they would control for B12 status (esp b/c B12 is very easy to supplement). B6 important to supplement too (I mean, B6 is IN the supplement stack of that buck professor)

Should try creatine to reduce.

Also SAM-e directly feeds into it so SAM-e BAD

High homocysteine causes brain decline (the worst of things) and this could be a reason why some B-vitamins reduce brain decline.

This in Chinese people below (Gender- and age-related differences in homocysteine concentration: a cross-sectional study of the general population of China | Scientific Reports )

1 Like

In Sept, 2022, my homocysteine was 7.5. My previous measure in February, 2019 was 10.3. I am 58 years old now. I started taking a homemade version of Juvify’s GlyLo in November, 2021, and that includes a B6 supplement. I also supplement B12. My diet is keto, heavy on animal fats and moderate on protein (70g/day).

I had high homocysteine levels both from genetics (mthfr) and health issues (taking high dose PPIs for GERD). Now my tests come out at around 7. For me, taking b12 and methyl folate helped some, and taking choline seemed to help a bit. The thing that apparently helped the most was NAC. I’ve been taking it for a couple years now and my HST levels dropped by around 4. I was taking 1.2gms a day but now with the data of glynac, I’ve bumped it up to 2.4gms a day

1 Like

> what are the 1st, 10th, 25th, 50th, 75th, 90th, and 99th percentile homocysteine concentration of people?

The percentiles for homocysteine concentration in people would vary based on factors like age, diet, and health. Some general estimates include:

1st percentile: Around 5 μmol/L or less. Very low homocysteine, likely indicating adequate B vitamin status and metabolism.
10th percentile: Around 7 μmol/L. Still on the lower end of the normal range; low risk of deficiency or issues.
25th percentile: Around 8-9 μmol/L. Within the normal, healthy range but may indicate some increased risk of B vitamin deficiency or impaired metabolism in some cases.
50th percentile (median): Around 10-12 μmol/L. The median for a generally healthy population likely with adequate but not excessive B vitamin and metabolism status.
75th percentile: Around 13-15 μmol/L. On the higher end of normal; some risk of deficiency/impaired metabolism for certain individuals. Supplements/diet changes could help.
90th percentile: Around 16-18 μmol/L. Some risk of hyperhomocysteinemia which can increase heart disease risk; warrants diet/lifestyle evaluation and potentially B vitamin treatment for some.
99th percentile: Around 19 μmol/L or above. Very high homocysteine which may indicate a genetic issue or B12/folate deficiency; requires medical evaluation and treatment to lower risk.

These are general estimates. The precise percentiles would depend on a variety of individual and population factors. Both high and low homocysteine can indicate issues in some cases. Elevated homocysteine is a risk factor for heart disease, but levels should be evaluated in context. A doctor can assess homocysteine along with symptoms and other health factors to determine appropriate treatment or further testing. Diet/lifestyle changes and B vitamin supplements may help address high homocysteine, but medical advice is necessary for individual cases.

> what are the 1st, 10th, 25th, 50th, 75th, 90th, and 99th percentile homocysteine concentration of 25-year olds?

The percentiles for homocysteine concentration in 25-year-olds would likely be generally lower than for older populations, but the exact values would depend on factors like diet and health in 25-year-olds. Some estimates could be:

1st percentile: Around 4 μmol/L or less. Very low homocysteine in healthy young people with adequate nutrition.
10th percentile: Around 6 μmol/L. Still low, indicating good B vitamin and metabolism status for age.
25th percentile: Around 7-8 μmol/L. Within the healthy range but some risk of deficiency/impaired metabolism in less healthy individuals.
50th percentile (median): Around 8-10 μmol/L. The median for 25-year-olds would likely be on the lower end of normal, reflecting good health and nutrition at this age.
75th percentile: Around 10-12 μmol/L. Higher than median but still normal for age; some may have deficiencies or impaired metabolism, warranting diet/lifestyle evaluation.
90th percentile: Around 13-15 μmol/L. Elevated for age and warrants homocysteine-lowering changes; some risk of hyperhomocysteinemia and related health issues in less healthy individuals.
99th percentile: Around 16 μmol/L or above. Very high for age and requires medical evaluation; may indicate genetic issues or severe deficiency that necessitates treatment to reduce risks.

However, these are rough estimates. The precise homocysteine percentiles for 25-year-olds would depend on the attributes and diets/lifestyles of people of this age. In general, homocysteine levels would likely be lower than in older populations. But both high and low homocysteine can indicate issues at any age, so values should be evaluated based on symptoms and other health factors. Medical advice is necessary for individual cases of very high or very low homocysteine.

> what are the 1st, 10th, 25th, 50th, 75th, 90th, and 99th percentile homocysteine concentration of 18-year olds?

The percentiles for homocysteine concentration in 18-year-olds would likely be lower than for older populations, reflecting good health and nutrition at this age. Some estimates could be:

1st percentile: Around 3 μmol/L or less. Very low homocysteine in healthy young people with adequate nutrition.
10th percentile: Around 5 μmol/L. Still low, indicating good B vitamin and metabolism status for age.
25th percentile: Around 6-7 μmol/L. Within the healthy range but some risk of deficiency/impaired metabolism in less healthy individuals.
50th percentile (median): Around 7-8 μmol/L. The median for 18-year-olds would likely be low, reflecting good health and diet at this age.
75th percentile: Around 8-9 μmol/L. Higher than median but still normal for age; some may have deficiencies or impaired metabolism, warranting diet/lifestyle evaluation.
90th percentile: Around 10-12 μmol/L. Elevated for age and warrants homocysteine-lowering changes; some risk of issues in less healthy individuals.
99th percentile: Around 13 μmol/L or above. Very high for age and requires medical evaluation; may indicate genetic issues or severe deficiency that necessitates treatment.

However, these are rough estimates. The precise homocysteine percentiles for 18-year-olds would depend on the attributes and diets/lifestyles of people of this age. In general, homocysteine levels would likely be lower than in older populations. But both high and low homocysteine can indicate issues at any age, so values should be evaluated based on symptoms and other health factors. Medical advice is necessary for individual cases of very high or very low homocysteine.