I was a bit surprised that despite being off the rail when it came to dieting over the holidays, the weight I had lost before Christmas didn’t come back on. I’d lost about 8lbs through diet and exercise, and in similar circumstances, my body would have normally regained much of it back during the holidays and the excessive calories that comes with it. Fighting with my weight has been a constant battle and keeping weight off takes a lot of diligence for me.
I did see this 2014 pubmed article on rapamycin and weight setpoints. I wonder if others have seen this phenomenon as well?
I wish that was my experience. I’ve gained about 8 pounds since I started rapa this summer. I take 6mg every Saturday morning on an empty stomach. Weighed in at 189 last morning but average around 185. Would a higher dose help?
I have to agree with Agetron.
After taking rapamycin for a few months I finally lost the last few pounds that seem so difficult sometimes to lose.
What is really surprising to me is how stable my weight is now without watching what I eat.
Rapamycin seems to be a great weight stabilizer, for me at least.
FWIW: I have been taking doses of 5 - 20 mg of rapamycin. High doses every 2 weeks, lower doses every week. Currently, I am on a vacation from rapamycin to see if I can get my blood work results back to norm.
Well joelklee might be time to get on TRT - Maverick78 could be onto something there. Thanks bud.
Regardless of your position on TRT-- that with rapamycin… my blood panel excellent health, Dexa scan, Coronary Calcium Scan, Body Composition are all excellent normal and I will be 65 in a few months. My physician says you are amazing - stay the course.
I’ve been on TRT since my mid 40s due to low T (I am 56 now). AFAIK it’s not life extending but it can be life enhancing. In my experience testosterone “wants” me to be bigger. I probably packed on 10 pounds within a few years of starting. Even if it’s only muscle, beyond a certain weight, that probably is not a good thing from a life extension point of view. (e.g. more heart stress, higher blood pressure, etc.).
I’m currently taking Pfizer rapamune courtesy a friend of a friend in Turkey. That was a one-shot deal. When I run out, I have a script at amazon pharmacy for generic sirolimus valid for a few more refills.
Can you provide more details about your gfj protocol? What’s the source (fresh squeeze yourself, canned, etc.), amount, timing?
I get a Red Grapefruit from Wal-Mart produce… it’s what they stock.
Just before my rapamycin dose…I slice the Grapefruit in half and then half again (quarters). Then, with my hands squeeze each section into a glass… strain it… and I get about 5 fluid ounces.
I swallow my 2mg rapamycin pill with the squeezed GFJ. I get an increase of 6 times… based on all my LABCORP test. You can get anywhere from 3 to 6 multiplication of the dose. Each person is different. It definitely will extend your supply of rapamycin.
LMK… if you have other questions.
P.S. thanks for sharing your TRT… info. Typically it melts fat… builds muscle. For me extended use of rapamycin will start to shred and remove all extra fat in your muscles… more strength…less bulk.
Thanks for the detailed info. After doing some research, I am going to push pause on boosting dosing levels with GFJ. Before doing so, I’d like to measure baseline levels of rapa and several other things which will require more study.
I’m more comfortable getting a more modest boost from fat (I’ve been taking rapa on an empty stomach before breakfast). I understand that @RapAdmin takes rapa with a can of sardines but I’m hoping for something a little more palatable. @desertshores do you still take rapa with olive oil? If so can you share your dosing protocol?
Somewhere I have read that the “Red Grapefruits” have less narigin, one of the important flavonoids responsible for the cytochrome enzymes, than the white and more bitter fruits. I apologize for the lack of citation; I believe it came from the Florida Citrus Association.
I have taken rapamycin for a few months two different times, and I often wonder if it reset my weight set point.
It’s hard to know because I made a lot of changes at the same time, but at the beginning of the pandemic I lost 30 pounds just from switching the 1.5 hours a day I went to a restaurant for lunch or dinner, to cooking for myself and walking 1.5 hours a day. I made no attempt to lose weight; it just came off from that one change.
I’ve also done a strict “healthy” keto diet ~3 times for 3-5 months at a time during the last two years (after losing the initial weight). I lost another 5-10 pounds doing keto.
But one thing I have definitely noticed, is that I don’t gain weight back like I used to pre-rapamycin (or pre-keto? or pre-walking a lot?)
I weighed myself yesterday after not doing so for ~3 weeks, and was sure I would have gained weight because I feel like I’ve been eating a lot more, and I haven’t been walking because of the bad weather and I’ve had some big work deadlines. But nope…I hadn’t gained a single pound.