I find this dichotomy ironic.
Vaccines decrease aging and increase lifespan as shown by new research
The current administration of the U.S. government is railing against vaccines.
No wonder the US is spending the most and seeing the shortest lifespans. I expect this trend to get worse. Unfortunately, it’ll probably show up in another administration’s data and they’ll get blamed for it.
They need to start calling them “peptides” and the research will progress faster 
I’m surprised that this is even considered controversial on X, I thought people didn’t like the COVID vaccines.
But it appears there’s vaccine hesitant active on social media. I guess they swarm around it after a few influencers from that area repost it. They’re radicalized?
Vaccines are one of the best inventions ever.
I got my shingrix yesterday. 12 days after my 6 mg rapamune. And I got quite a bit of known side effects.
Pain at the injection site. Muscle pain. tiredness/fatigue, headache, chills and feverlike/fluelike symptoms but no abnormal temperature.
Maybe I should have waited longer than 12 days after my last dose of rapamune?
Any ideas from the forum?
@Curious I got my shingles vax before ever starting rapa, and I thought I might die from the side effects 
I’ve never heard of anyone feeling as awful as I did after my first two covid vaccines, but shingles took the prize.
It’s impossible to know for sure, but you might have felt that way regardless of when you took your dose. 12 days sound like plenty of time to me, fwiw.
Its something that requires more knowledge about the person concerned, but superficially it would not appear that Rapa had that much effect.
I am going for my next dose in about 2 months time. Then I am more prepared to get a few days of these “fluelike” symptoms.
My wife’s arm “felt a little sore” but I had the stage 5 reaction that Beth and Curious report. So it is largely individual dependent. I’m glad it’s done though given the data on dementia.
I was not on a break from Rapa when I had my Shingrex done. My reaction was pretty normal and mild - mild pain, mild headache - for 2 days which was not so bad.
If the idea of a vaccine is to train the immune system then i want my immune system fully functioning to do the training.
I took a complete break from Rapa when doing the Shingrix pair of injections.
But but…
I don’t remember all the details but Rapamycin increased the effectiveness of a flu vaccine back many years ago.
Then there is this.
https://www.nature.com/articles/s41577-018-0052-0
Enhanced formation of memory CD8+ T cells… By several authors
Rapamycin is an immune modulator rather than an immune suppressant. Not sure the answer regarding your shingles vaccine. But the answer is not clear cut.
flemming2018.pdf (519.5 KB)
You are absolutely right, it is not clear cut and i could be totally wrong. But I don’t stop months in advance of a vaccine, only 3-4 weeks.
Taking a break does no harm.
My understanding is that rapamycin lowers innate immunity => side effects like fever, etc.
But boosts formation of CD8+ T cells, etc…
I’m not sure about the antibody responses and how they’re effected while on rapamycin, but yes, the Mannick et. al trial showed that there is a boost after everolimus + a washout period of a week
Yep, here’s a write-up about the 2018 mannick study
I just got mine and I’ve had a rough 24 hours. My HRV tanked and my heart rate didn’t get below 82 during the night.
It better be worth it.
My wife actually got shingles a few years ago, and that looked super brutal. (And she later got the vaccine, and had almost no reaction). Either way, I’d like to believe that shingles is worse than whatever the vaccine can throw at us!
Which reminds me, I also keep intending to get the vaccine, but keep procrastinating it.
Also, @Beth you were going to ask your doctor about HPV vaccination etc, or self-paying. Did you get anywhere with that?
@relaxedmeatball I’ve said the same… you don’t want the side effects from the shingles vax… well, I imagine you won’t enjoy them from a case of shingles either.
I’m always impressed by your memory! Yes, I did run it by my doc, and he said it made a lot of sense because they give the vax to people with throat cancer.
I had it scheduled at CVS (one of the largest US pharmacies) and they cancelled on me for being too old (RUDE)! I even called them and said I have a perscription from my doc, but they said CVS will not give any hpv vax to anyone over age, period (I’m in California, so I found that shocking).
Instead, I walked into Safeway and they happily gave me one and never asked to see my rx. I almost fell over when they told me my insurance would cover it 100% (my insurance is mostly useless)
The young woman giving the shot looked at me and my husband like there was something seriously wrong with us
On that note, I’ve been meaning to follow up to ask if we should get the second shot in the series. If I recall, you might have said one shot is enough for our ancient selves, or do we just go ahead and get all of them … any downside?
Fwiw, I was told there might be some side effects from the shot that would last a day or two, but there were none for me. I felt a little freaky for about a minute after the shot which was unlike anything I’ve experienced, and nerve wracking, but it quickly dissipated.
Multiple large observational studies have found that routine adult vaccines are associated with a reduced risk of dementia, with some showing risk reductions of 25% to 40%.
The strongest evidence exists for shingles, flu, RSV, pneumococcal and diphtheria, tetanus and pertussis-containing (DTP) vaccines.
Researchers believe vaccination may reduce dementia risk by preventing infections that cause brain inflammation, though some evidence points to a more general immune effect.
Associations:
lol
Around 90-95% of adults worldwide have been infected with Epstein-Barr virus (EBV)
