Ultrasound brain pulses put mice in a hibernation-like state

Interesting… lots of benefits to hibernation-like states… see this presentation by Fauna Biotech: The Longevity Summit, News & Update - #10 by RapAdmin

Today’s news:

The paper:

Induction of a torpor-like hypothermic and hypometabolic state in rodents by ultrasound

Open Access:

Torpor is an energy-conserving state in which animals dramatically decrease their metabolic rate and body temperature to survive harsh environmental conditions. Here, we report the noninvasive, precise and safe induction of a torpor-like hypothermic and hypometabolic state in rodents by remote transcranial ultrasound stimulation at the hypothalamus preoptic area (POA). We achieve a long-lasting (>24 h) torpor-like state in mice via closed-loop feedback control of ultrasound stimulation with automated detection of body temperature. Ultrasound-induced hypothermia and hypometabolism (UIH) is triggered by activation of POA neurons, involves the dorsomedial hypothalamus as a downstream brain region and subsequent inhibition of thermogenic brown adipose tissue. Single-nucleus RNA-sequencing of POA neurons reveals TRPM2 as an ultrasound-sensitive ion channel, the knockdown of which suppresses UIH. We also demonstrate that UIH is feasible in a non-torpid animal, the rat. Our findings establish UIH as a promising technology for the noninvasive and safe induction of a torpor-like state.


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One of the things it does is cause the body to use only fat for energy. I wonder if this could lead to some new ways to treat obesity?

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