Timing of Rapamycin dosing with exercise

[martharox]

Sorry if this has already been asked…I’m wondering if anyone has advice on rapa dosing / timing relative to exercise. If I’m weight training 5 days a week, and I run 5 days a week (20-30 miles per week), is there an “ideal” day to take the rapa? I currently do my “long run” on saturdays, take 6 mg rapa on Saturday evening, and rest on Sunday. In light of the RAPA-EX-01 study, has anyone adjusted their regimen?

[Agetron]

What you currently are doing makes a lot of sense.

I do similar… after a gym evening work out, I dose 6 mg. This is weekly…, I skip a workout the next day. Typically I hit the gym every other day.

[dwglinn]

Thank you for your post. I have been debating this very topic with myself recently. I have a daily exercise and diet regimen which I alter when I take my medication. I take my medication on Wednesday evening around nine 9 PM I stop I take my medication before bed around 9 PM.eating every day between 3 and 4 PM. In other words, I fast five or six hours before I take my medication and around I fast 15 or 60 hours before I eat again

[qBx123Yk]

Plenty of discussion in these 2 threads:

Results of Stanfield Rapamycin Study? Caused change in usage?

Considering the recent results of the Dr. Brad Stanfield Rapamycin study on exercise capability (on humans), which showed worse exercise capacity in the rapa group than the placebo group, did that cause anyone who was taking rapa to stop taking it? Or change dosage or scheduling of it?

Update on Brad Stanfield's Rapamycin Clinical Study in NZ

Finally… [Screenshot 2026-04-15 at 5.46.06 PM] Source: https://x.com/BradStanfieldMD/status/2044576710092615875?s=20 Full Paper/Open Access: https://onlinelibrary.wiley.com/doi/epdf/10.1002/jcsm.70274 Rapamycin Blunts Exercise Adaptations in Older Adults: Results from the RAPA-EX-01 Trial Preclinical models have long established that the mechanistic target of rapamycin complex 1 (mTORC1) acts as a central regulator of both aging and skeletal muscle growth. Inhibiting mTORC1 with rapamycin extends lifespan in rodents, but intact mTORC1 signaling remains strictly required for skeletal muscle hypertrophy in response to mechanical overload. This paradox originated the “cycling hypothesis”: deliberately alternating mTORC1 inhibition for systemic rejuvenation and activation for post-exercise adaptation to maximize healthspan. The RAPA-EX-01 trial sought to directly test this hypothesis in humans. Investigators randomized 40 sedentary older adults (aged 65–85) to receive either 6mg of…

[dwglinn]

If I remember correctly, Stanfield research did not reach statistical significance.