Joseph
September 23, 2023, 5:00pm
#1
In my view;
These two papers/documents deserves a thread of their own. As some will not see/read the original thread.
Ths was posted on this forum by member “scta123” at Senolytic Therapy: What are you doing? - #142 by scta123
Thank you “scta123” for the information.
“Doxycycline, Azithromycin and Vitamin C (DAV): A potent combination therapy for targeting mitochondria and eradicating cancer stem cells (CSCs)”
Here, we devised a new strategy for eradicating cancer stem cells (CSCs), via a “synthetic-metabolic” approach, involving two FDA-approved antibiotics and a dietary vitamin supplement. This approach was designed to induce a “rho-zero-like” ...
Patent
“Three-drug combination therapy for anti-aging”
As I posted in the original thread;
This is a no brainier to do.
“For 5 weeks, azithromycin was administered at 250 mg twice weekly, doxycycline at 100 mg twice daily, and vitamin C at 500 mg once daily”
Will be doing this as quickly as I can get to a local pharmacy to pick up the azithromycin and doxycycline.
I will be using a much larger amount of Vitamin C.
“If you wait until you are ready, it is almost certainly too late.”
~ Seth Godin
“I am not the waiting type”
~ Joseph
9 Likes
Joseph
September 23, 2023, 5:13pm
#2
FWIW
30x 250mg azithromycin - $17.46 with a GoodRx discount card in North New Jersey area at WEIS Pharmacy
75x 100mg doxycycline - $17.81with GoodRx discount card in North New Jersey area at a WEIS Pharmacy
Yes, you would require a prescription.
“In the examples of anti-aging embodiments, treatment with this approach was directed over a repeating cycle. The compositions include azithromycin as a first antibiotic that inhibits large mitochondrial ribosomes, doxycycline as a second antibiotic that inhibits small mitochondrial ribosomes, and vitamin C as an oxidation promoter to induce mitochondrial oxidative stress. Including For 5 weeks, azithromycin was administered at 250 mg twice weekly, doxycycline at 100 mg twice daily, and vitamin C at 500 mg once daily. A 77-year-old man of interest had hair growth, mental cognition and agility, strength and stamina, and increased libido, as well as visual acuity, hearing, conversation, coordination and balance, overall well-being and vitality. Reported improvement. The recipient also reported the disappearance of clinically palpable prostate nodules after treatment with this approach, with no other medications, diet, exercise, and changes in daily life.”
4 Likes
kansel
September 23, 2023, 5:39pm
#3
Indian pharmacy here i come.
1 Like
kansel
September 23, 2023, 5:46pm
#4
@Joseph Since these are antibiotics (if I’m not mistaken) they can only be taken periodically/rarely, right? let’s say once per year? or these need/should/could be taken continuously daily?
Joseph
September 23, 2023, 5:51pm
#5
FWIW
If you review the documents/paper course was for 5 weeks.
FWIW
30x 250mg azithromycin - $15.00 with a GoodRx discount card in North New Jersey area
75x 100mg doxycycline - $18.00 with GoodRx discount card in North New Jersey area.
Yes, you would require a prescription.
2 Likes
scta123
September 23, 2023, 6:08pm
#6
250 mg azithromycin twice weekly does not have any antibacterial properties according to the text and 100-200 mg doxycycline is a standard acne dose that is safe to take for months or even old school malaria prophylaxis. Text also suggests that if bacteria antibiotic resistance would be problematic doxycycline dose could be lowered to e.g. 20 mg which is again non antibacterial and has no effect on bacteria but still provides enough mitochondrial inhibition.
Vitamin C proposed is ascorbyl palmitate .
5 Likes
scta123
September 23, 2023, 6:17pm
#7
but the list of claims is quite impressive:
anticancer activity,
selectively kills senescent cells
tissue repair and regeneration
extends lifespan and healthspan
prevents hair loss, hearing loss, poor eyesight, memory loss, mental retardation, joint stiffness, muscle weakness, loss of physical strength, slowness, loss of balance, loss of endurance, loss of agility, sexual dysfunction, loss of energy, loss of testosterone
prevents cellular waste deposition, and inflammation
improves hair regeneration, hearing, visual acuity, memory, intelligence, joint mobility, muscle growth, muscle strength, muscle endurance, speed, sense of balance, agility, and sexual ability
restores hair growth, restores original hair color, restores muscle coordination and gait, restores overall mobility, increases muscle mass, enhances grip strength, enhances concentration, spirit
enhances clarity and enhances memory
(I tried my best to go trough text and copy the main claims)
6 Likes
kansel
September 23, 2023, 6:23pm
#8
scta123:
restores hair growth, restores original hair color, restores muscle coordination and gait, restores overall mobility, increases muscle mass, enhances grip strength, enhances concentration, spirit
This is what might make me try it Almost obsessed with maintaining healthy youthful looking hair LOL
5 Likes
Joseph
September 23, 2023, 6:28pm
#9
As I have posted;
“This is a no brainier to do.”
3 Likes
kansel
September 23, 2023, 6:36pm
#10
Has any of the dudes in here done it yet and if so what’s the experience?
LaraPo
September 23, 2023, 6:52pm
#11
Prescription is a big obstacle!
Joseph
September 23, 2023, 6:55pm
#12
It is not that big an obstacle.
You can get a prescription online the same day.
kansel
September 23, 2023, 6:55pm
#13
Never a problem with me and my Indian friends
5 Likes
Apologies if I’m being dense, maybe I missed something, but what’s the source of this and are there any papers to back it up?
Is this a company or a lab?
2 Likes
kansel
September 23, 2023, 8:35pm
#16
My only issue (if i had one) is how come these studies came out over 5 years ago and no one of the longevity doctors that keep plastering their faces daily on tv/computer screens and never mentioned this. To me this is bigger than RAPA or anything I’ve seen so far on longevity and wellbeing front, with cancer fighting capabilities to boot. Could this be too good to be true, or is this so good that no one wants it to get out there?
5 Likes
Joseph
September 23, 2023, 8:39pm
#17
Paul
Review the paper and patent original posted on this forum by member “scta123”
In my view;
These two papers/documents deserves a thread of their own. As some will not see/read the original thread.
Ths was posted on this forum by member “scta123” at Senolytic Therapy: What are you doing? - #142 by scta123
Thank you “scta123” for the information.
“Doxycycline, Azithromycin and Vitamin C (DAV): A potent combination therapy for targeting mitochondria and eradicating cancer stem cells (CSCs)”
Patent
“Three-drug combination therapy for anti-aging”
As I posted in the original thread;
“If you wait until you are ready, it is almost certainly too late.”
~ Seth Godin
“I am not the waiting type”
~ Joseph
This is all off the shelf items, the is no money to be made in non IP products.
1 Like
Joseph
September 23, 2023, 8:40pm
#18
No one can make any money, no IP possible.
Total cost for this for 5 weeks is less than $50.00
30x 250mg azithromycin - $15.00
75x 100mg doxycycline -$18.00
Vitamin C as ascorbyl palmitate - $10.00
What is there to think about?
5 Likes
JuanDaw
September 23, 2023, 8:41pm
#19
Azithromycin as a senolytic was discussed in age reversal forum four years ago; five years ago in longecity.
3 Likes
kansel
September 23, 2023, 8:47pm
#20
If you knew it that long ago you should have tried it dude. Rest assured I’ll give it a try as soon as my indiands wake up smile:
3 Likes