Hi!
So we know rapamycin has been proven to extend the lifespan of multiple organisms. However there are other molecules that do the same such powerful senolytics such as Dasatinib + Quercetin, metformin & micro-dosed lithium to some extent. I may of forgot some but these seem the most promising. If you know of any other molecules that have been shown to increase lifespan please post them below. ![]()
Eliminating senescent cells extends healthy life in mice
Mice given dasatinib-quercitin lived 36% longer and in better health
Lithium Produces Mildly Positive Effects on Healthspan in Mice
Metformin improves healthspan and lifespan in mice
I have always been curious on what would happen to a mice/organism if scientists combine all the molecules together? Will it increase the lifespan/health more than just rapamycin alone? or dasatinib + quercitin alone? What would happen if you give a mice rapamycin, metformin, dasatinib + quercetin and lithium? Recent study showed Rapamycin + Acarbose combined lifespan of male mices by 29% so if you combine rapa + acarbose with dasatinib + quercetin would the lifespan benefits add up together to 35% 50%? These questions really make me so curious! I know none of us know the answer but its interesting to hear others thought.
I’m currently taking all the molecules apart from dasatinib + quercetin, even though I have access to these molecules. I’m doing more research first and thinking about adding it to my stack.
I really hope scientist in the future try combing the molecules that actually have been shown to increase lifespan/health span in organisms.

