The Efficacy and Safety of Β-Nicotinamide Mononucleotide (NMN) as Anti-Aging Supplementation in Healthy Middle-Aged and Older (40-65 Years Old) Adults: A Randomized, Multicenter, Double-Blind, Placebo-Controlled, Parallel-Group, Dose-Dependent Human Clinical Trial
The biological age change was unimpressive, maxing out at -2.54% after 60 days. Much more impressive was the 50% increase in the distance of a six-minute walk:
The mean percentage increases of the distance walked in six minutes over baselines were -4.56%, 13.88%, 38.10%, and 31.48% at day 30 and 1.60%, 23.64%, 50.18%, and 48.4% at day 60 for placebo, 300mg, 600mg, and 900mg respectively.
It was a double-blinded but small study (80 total participants), so I take it with a grain of salt. Certainly the supplement is worth a try if you feel your energy level has declined a lot with age. I’m not there yet.
Indeed, biological age result essentially meaningless…it takes several months for epigenetics to reprogram the methylome. (private communication with myDNAge…they recommend waiting 6 months). And there are some reproducibility issues with these first age DNA tests.
I think this estimate is inaccurate (seems high), where did you get this number? ResTOR Bio only had a total funding of approx. $65 Million, and that funding when towards many things besides their clinical trial (e.g. corporate overhead, executive salaries, etc…)
Brad Stanfield did a good critical review of this paper, concentrating on the major defect in the blinding (participants knew how many capsules they were taking, and it varied by dosage). Also, there were problems with: (1) how short were the distances initially walked, (2) how much the control group’s bioage changed during the study to be much older, (3) chronological age differences between the control group and intervention groups, (4) sponsorship by a branded NMN manufacturer.