Tetracyclines: nonantibiotic properties and their clinical implications

[Joseph]

This article would apply to doxycycline.

Tetracyclines: nonantibiotic properties and their clinical implications - PubMed

[Bicep]

Nice paper, thanks:

https://sci-hub.se/10.1016/j.jaad.2005.10.004

There are several small clinics around the country (Riordan, Care…) that recommend things like metformin, doxycycline, Vitamin C,…long list of recycled drugs and supplements to help stop the cancer. Always wondered why doxycycline was in there. Now I have a better idea.

[desertshores]

Interestingly, depending on where you live, you can buy USP-grade tetracycline and some other antibiotics from some pet stores and farm supply stores without a prescription. I haven’t been to my local aquarium supply store in decades, but I used to get it to treat some tropical fish diseases when I was into home aquariums.
Maybe Agetron or some of the other farmers would know something about this. Some farmers treat chickens with tetracyclines.

[Joseph]

But still no document showing why rapamycin with doxycycline?

And not just because “fill in the name” takes it.

[KarlT]

Clinically I have noticed a remarkable number of patients get stomach upset from doxycycline.

[Joseph]

@KarlT

“Clinically I have noticed a remarkable number of patients get stomach upset from doxycycline.”

At what dose?

Have you/ do you use doxycycline in low dose for inflammation?

Doxycycline Hyclate - A Quick Medical Review Earn CME/CE in your Profession:

From Statpearls article/review below Anti-inflammation Doxycycline hyclate can be taken at sub-acute doses of 40 mg daily for anti-inflammatory effects. The anti-microbial mechanism will not be in action at this sub-antimicrobial dose, sparing healthy bacteria and maintaining the body’s microbiome.

Anti-Inflammatory Properties of Low and High Doxycycline Doses: An In Vitro Study

“High dose administration (100 or 200 mg/day) is often responsible for development of bacterial resistances and endogenous flora alterations, whereas low doses (20–40 mg/day) do not alter bacteria susceptibility to antibiotics and exert anti-inflammatory activities” From paper below;

[KarlT]

@Joseph

At what dose?

Almost never prescribe. Just see patients with side effects from standard dose of 100 mg.

[macneu2299]

@Joseph

Have you/ do you use doxycycline in low dose for inflammation?

Should we have this question posted for everyone?

[Joseph_Lavelle]

I took tetracycline for 20 years for acne. I have the freckles to prove it. I always figured I would die young because of it…maybe I’ll live long instead?